2018
DOI: 10.1080/14767058.2017.1418222
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Effects of ciprofloxacin and quercetin on fetal brain development: a biochemical and histopathological study

Abstract: Unlike these results when some parameters are evaluated it is understood that this harmful effects suppressed by quercetin.

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Cited by 9 publications
(7 citation statements)
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“…However, ciprofloxacin did impair the overall mtDNA integrity in post-mitotic cells (Figure 4D ). As our detection method (long-range PCR) does not distinguish between strand-breaks, abasic sites or base alterations inhibiting Taq polymerase, the observed effect might be caused by oxidative damage, which fluoroquinolones have been reported to induce in a variety of cell types ( 41 , 42 ).…”
Section: Discussionmentioning
confidence: 99%
See 1 more Smart Citation
“…However, ciprofloxacin did impair the overall mtDNA integrity in post-mitotic cells (Figure 4D ). As our detection method (long-range PCR) does not distinguish between strand-breaks, abasic sites or base alterations inhibiting Taq polymerase, the observed effect might be caused by oxidative damage, which fluoroquinolones have been reported to induce in a variety of cell types ( 41 , 42 ).…”
Section: Discussionmentioning
confidence: 99%
“…Ciprofloxacin has also been reported to interfere with physiologically significant cell differentiation processes, such as spermatogenesis ( 57 ), brain development ( 41 ), bone mineralization ( 58 ), as well as to induce renal toxicity and heart arrhythmia ( 59 ). While the molecular mechanisms of these adverse effects are yet unclear, mitochondria play a central role in all of these physiological processes, making mitochondrial impairment a likely culprit for the disturbed cellular physiology.…”
Section: Discussionmentioning
confidence: 99%
“…Administer of quercetin 20 mg/kg of quercetin was administered with olive oil and oral gavage (for 15 days) [7].…”
Section: Euthanasiamentioning
confidence: 99%
“…In a typical Western diet, the daily intake of quercetin is estimated to be in the range of 0 and 30 mg [ 112 ]. Quercetin shows unique biological properties at the basis of potential benefits to overall health and disease resistance, in fact, it exhibits anticarcinogenic, anti-inflammatory, antiviral, anti-hypertensive, and antioxidant effects as well as it may inhibit lipid peroxidation and platelet aggregation and it can stimulate mitochondrial biogenesis [ 114 , 116 , 117 , 118 ].…”
Section: Polyphenols’ Effects In Dedmentioning
confidence: 99%