Effects of Chronic Organophosphate Pesticide Exposure on the Central Nervous System

Korsak, Richard J.; Sato, Miles M.

doi:10.3109/15563657708989822

Cited by 86 publications

(33 citation statements)

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“…The cognitive processes that appear to be mainly impaired are sustained attention, memory, problem solving, and speed of information processing (Roldán-Tapia et al 2005;Kaplan et al 1993;Fiedler et al 1997;Stephens et al 1995;Steenland et al 1994;Rosentock et al 1991;Savage et al 1988;Korsak and Sato 1977). Also, emotional deficits have been found after exposure to OPs (Yokoyama et al 1998;Steenland et al 1994;Savage et al 1988).…”

Section: Introductionmentioning

confidence: 95%

Vulnerability of long-term neurotoxicity of chlorpyrifos: effect on schedule-induced polydipsia and a delay discounting task

et al. 2006

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Section: Introductionmentioning

confidence: 95%

Vulnerability of long-term neurotoxicity of chlorpyrifos: effect on schedule-induced polydipsia and a delay discounting task

et al. 2006

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“…Literature on human exposure showed long-term alterations in neuropsychological performance. Furthermore, deficit in information selection, memory, reasoning, sustained attention, problem-solving and speed of information processing, and even irritability, depression as well as neuropsychiatry symptoms have also been reported (Korsak and Sato 1977;Savage et al 1988;Rosentock et al 1991;Kaplan et al 1993;Steenland et al 1994;Stephens et al 1995;Fiedler et al 1997;Yokoyama et al 1998;Roldán-Tapia et al 2005, 2006.…”

Section: Introductionmentioning

confidence: 96%

Impulsivity as Long-Term Sequelae After Chlorpyrifos Intoxication: Time Course and Individual Differences

et al. 2010

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Chlorpyrifos (CPF) is a common organophosphate (OP) insecticide that has been widely used in agriculture as a pesticide. The primary mechanism of acute toxic action of OPs is initiated by acetylcholinesterase (AChE) inhibition. However, non-AChE targets have also been proposed as alternative that contributes to the acute lethal action and side effects of short or long-term exposure. Recently, we have found that a single dose of 250 mg/kg CPF produces acceleration in acquisition on schedule-induced polydipsia (SIP) procedure 6 months after its administration. Moreover, CPF animals show a higher level of impulsivity in a delay-discounting task 1 year after acute administration, and these effects are potentiated when animals are divided into high (HD) and low (LD) drinkers in SIP. In the present study, rats were injected with a subcutaneous (sc) dose of 250 mg/kg of CPF, and 10 weeks later its effect on delay-discounting task was evaluated. Consequently, these animals were evaluated based on SIP, and divided into two populations (HD and LD) according to their rates of drinking in this task. One year after OP administration, these animals were re-evaluated in a delay-discounting task. Results revealed that the CPF-administered rats prefer immediate reward and show a more impulsive choice, 10 weeks after CPF administration. Furthermore, 1 year after it administration, only animals treated with CPF that are high drinkers on SIP are more impulsive than the rest of the groups Therefore, these data suggest that some individuals are more sensitive to OP intoxication than the others, at least in terms of durability of sequelae.

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“…B. [35,62,67]) -berichtet. Durchaus nicht immer erfolgte auch eine neurologische Untersuchung.Auch erbrachte nicht jede Studie überhaupt Abweichungen in den gewählten Messparametern [4,22,29,74].…”

Section: Fall-kontroll-und Kohortenstudien Mit Pestizidexponierten -Uunclassified

Pestizidexposition und Parkinson-Syndrom

Vieregge

2002

Der Nervenarzt

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Retrospective case-control studies among patients with idiopathic Parkinson's syndrome (IPS) show a positive association to the existence of a - mostly premorbid - exposure to pesticides. In acute pesticide intoxications, usually symptoms other than parkinsonism are found. Therefore, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) continues to be the agent best documented both experimentally and clinically to cause a clinical syndrome comparable to IPS. It is debated whether still unknown effects between exogenous pesticide exposure and the xenobiotic enzyme system may lead to IPS in single genetically susceptible individuals. In practice, the present data on the problem of pesticide exposure in IPS are irrelevant for medicolegal considerations.

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Effects of Chronic Organophosphate Pesticide Exposure on the Central Nervous System

Cited by 86 publications

References 8 publications

Vulnerability of long-term neurotoxicity of chlorpyrifos: effect on schedule-induced polydipsia and a delay discounting task

Vulnerability of long-term neurotoxicity of chlorpyrifos: effect on schedule-induced polydipsia and a delay discounting task

Impulsivity as Long-Term Sequelae After Chlorpyrifos Intoxication: Time Course and Individual Differences

Pestizidexposition und Parkinson-Syndrom

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