Effects of chronic mild stress on the oxidative parameters in the rat brain

Lucca, Giancarlo; Comim, Clarissa M.; Valvassori, Samira S.; Réus, Gislaine Z.; Vuolo, Francieli; Petronilho, Fabrícia; Dal‐Pizzol, Felipe; Gavioli, Elaine C.; Quevedo, João

doi:10.1016/j.neuint.2009.01.001

Cited by 233 publications

(136 citation statements)

References 31 publications

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“…The different kinds of stress can cause reduction of body weight in experimental animals (Gamaro et al 2003, Bekris et al 2005, Zardooz et al 2006, Lucca et al 2009). In the present study, the weight of Wistar rats exposed to construction noise for one year was less in comparison to the rats kept under normal noise level.…”

Section: Discussionmentioning

confidence: 99%

Effects of long-term construction noise on health of adult female Wistar rats

Žymantienė¹,

Želvytė²,

Pamparienė³

et al. 2017

Polish Journal of Veterinary Sciences

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The aim of this study was to investigate the influence of long-term building construction noise from refurbishment, which including vibration, on some physiological parameters and histopathological changes of organs of Wistar rats. Twenty 12 month old female rats were divided into two groups: rats group I (n = 10) were exposed to long-term construction noise and rats group II (n = 10) were kept under normal noise level. Study results revealed that long-term construction noise from building refurbishment has an influence on body weight, haematological and some serum biochemical parameters affects caecal microbiota, and causes histopathological changes in the organs of adult female Wistar rats. It was noticed that rats in group I exihibited significantly higher mean values for total protein, albumin and lower values for glucose, AST, ALT, blood urea nitrogen, haematological and caecal microbiota parameters than rats in group II. The most common pathologies were determined in the kidney, liver and lungs. Other observed pathologies were lymphadenopathy, catarrhal inflammation of the intestines, spleen hyperplasia and mammary gland adenofibroma. Single cases were subcutaneous fibroma in the thoracic region, abortus with uterine inflammation and thymus hyperplasia with formation of cysts were found.

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Section: Discussionmentioning

confidence: 99%

Effects of long-term construction noise on health of adult female Wistar rats

Žymantienė¹,

Želvytė²,

Pamparienė³

et al. 2017

Polish Journal of Veterinary Sciences

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“…Behavioral paradigms in rodents that are depressogenic (e.g., restraint stress, forced swim test) increase lipid peroxidation in several tissues (Sahin et al ., 2004; Lucca et al ., 2009; Runkel et al ., 2013; Spiers et al ., 2013). Similarly, tissue samples from psychiatric patients show increased levels of lipid peroxidation and depletion of antioxidant activities compared to samples from healthy controls (Do et al ., 2000; Bilici et al ., 2001; Gawryluk et al ., 2011; Ditzen et al ., 2012).…”

Section: Introductionmentioning

confidence: 99%

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

et al. 2015

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SummaryOxidative stress has long been associated with aging and has recently been linked to psychiatric disorders, including psychosis and depression. We identified multiple antipsychotics and antidepressants that extend Caenorhabditis elegans lifespan and protect the animal from oxidative stress. Here, we report that atypical antidepressants activate a neuronal mechanism that regulates the response to oxidative stress throughout the animal. While the activation of the oxidative stress response by atypical antidepressants depends on synaptic transmission, the activation by reactive oxygen species does not. Lifespan extension by atypical antidepressants depends on the neuronal oxidative stress response activation mechanism. Neuronal regulation of the oxidative stress response is likely to have evolved as a survival mechanism to protect the organism from oxidative stress, upon detection of adverse or dangerous conditions by the nervous system.

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“…Increase in proteins peroxidation in the frontal lobe of the brain, hippocampus, and striatum caused increase in lipid peroxidation in the cerebellum and corpus striatum, and decrease in activity of superoxide dismutase in the frontal lobe of the brain, hippocampus, and striatum of mice exposed to chronic unpredictable stress (Lucca et al, 2009). In a study by Grundmann et al (2010), chronic stress-induced depression caused decrease in anti-oxidant capacity and activity of glutathione per-oxidase, superoxide dismutase and catalase in the hippocampus and hypothalamus (Grundmann et al, 2010).…”

Section: Discussionmentioning

confidence: 94%

Study of antidepressant effects of grape seed oil in male mice using tail suspension and forced swim tests

Rabiei

Naderi

Rafieian-Kopaei

2017

Bangladesh J Pharmacol

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The aim of this study was to investigate the antidepressant effects of grape seed oil in male mice (n=60) using tail suspension and forced swim tests. Mice were divided to six groups of 10 in each group. Group I: Intraperitoneally receiving normal saline; Group II: Received normal saline & stress; Group III-V: Injected (i.p.) with different (60, 120, and 240 mg/kg) doses of grape seed oil; and Group VI: Received fluoxetine (10 mg/kg). Grape seed oil in 60 mg/kg significantly decreased immobility time in tail suspension and forced swim tests under chronic unpredictable stress compared to groups under chronic stress receiving normal saline and grape seed oil (120 and 240 mg/kg). Grape seed oil (60 mg/kg) significantly improved the motor balance in mice under chronic stress. It had no significant effect on serum corticosterone level. Grape seed oil can improve depression symptoms in mice.Video Clip of Methodology:0 min 14 sec <a href="https://youtube.com/v/7JgyR4mTUOw">Full Screen</a> <a href="https://youtube.com/watch?v=7JgyR4mTUOw">Alternate</a>

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Effects of chronic mild stress on the oxidative parameters in the rat brain

Cited by 233 publications

References 31 publications

Effects of long-term construction noise on health of adult female Wistar rats

Effects of long-term construction noise on health of adult female Wistar rats

Atypical antidepressants extend lifespan of Caenorhabditis elegans by activation of a non‐cell‐autonomous stress response

Study of antidepressant effects of grape seed oil in male mice using tail suspension and forced swim tests

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