Effects of long-term construction noise on health of adult female Wistar rats

Abstract

The aim of this study was to investigate the influence of long-term building construction noise from refurbishment, which including vibration, on some physiological parameters and histopathological changes of organs of Wistar rats. Twenty 12 month old female rats were divided into two groups: rats group I (n = 10) were exposed to long-term construction noise and rats group II (n = 10) were kept under normal noise level. Study results revealed that long-term construction noise from building refurbishment has an influence on body weight, haematological and some serum biochemical parameters affects caecal microbiota, and causes histopathological changes in the organs of adult female Wistar rats. It was noticed that rats in group I exihibited significantly higher mean values for total protein, albumin and lower values for glucose, AST, ALT, blood urea nitrogen, haematological and caecal microbiota parameters than rats in group II. The most common pathologies were determined in the kidney, liver and lungs. Other observed pathologies were lymphadenopathy, catarrhal inflammation of the intestines, spleen hyperplasia and mammary gland adenofibroma. Single cases were subcutaneous fibroma in the thoracic region, abortus with uterine inflammation and thymus hyperplasia with formation of cysts were found.

Acid sphingomyelinase mediates the noise‐induced liver disorder in mice

“…31 The imbalance between oxidation and anti-oxidation in our work might underlie the onset of NILD, given the oxidative stress facilitating apoptosis or lipid storage of hepatocytes. 20,22,32 We did not notice any significant response of NAD(P)H oxidase to noise stimulation, which was different from previous reports in which the enzyme played a key role in noise-induced cochlea injury, 33 suggesting that the oxidative adjustment after noise exposure is organ-or tissue-specific.…”

“…Next, we found that the noise caused significant apoptosis of hepatocytes which was related to mobilization of intrinsic pathway, indicating the mitochondrial associated cell loss might be one of the prominent features of noise associated damage as that was also present in periphery and central auditory pathway of mice suffering from noise trauma . The imbalance between oxidation and anti‐oxidation in our work might underlie the onset of NILD, given the oxidative stress facilitating apoptosis or lipid storage of hepatocytes . We did not notice any significant response of NAD(P)H oxidase to noise stimulation, which was different from previous reports in which the enzyme played a key role in noise‐induced cochlea injury, suggesting that the oxidative adjustment after noise exposure is organ‐ or tissue‐specific.…”

“…18 Serum corticosterone, AST or ALT activity in albino rats is enhanced by noise simulation. 19,20 Interference with 90-108 dB noise for 1 day increases the serum CK activity of rat. 21 Even with these reports, there are still gaps in our knowledge on NILD.…”

“…Hepatic glycogen, lactic acid and cholesterol are acutely increased in rats subject to noise irritation for 30 to 120 minutes . Serum corticosterone, AST or ALT activity in albino rats is enhanced by noise simulation . Interference with 90–108 dB noise for 1 day increases the serum CK activity of rat .…”

Vibration in mice: A review of comparative effects and use in translational research

“…Sources of vibration that occur within the animal facility include ventilation systems, husbandry‐associated cleaning and sterilizing equipment, ventilated racks, and cage change stations . There are several studies regarding the numerous effects of construction noise and vibration on rodents that have detailed effects such as increases in corticosterone levels and other alterations in biochemical parameters or reproductive efficiency . Recently, studies have begun to separate the effects of construction noise vs vibration.…”