2008
DOI: 10.1111/j.1530-0277.2008.00699.x
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Effects of Chronic Ethanol Feeding on Murine Dendritic Cell Numbers, Turnover Rate, and Dendropoiesis

Abstract: Background Chronic alcoholics have increased susceptibility to and severity of infection, which are likely to be a result of impaired immune defense mechanisms. The contribution of dendritic cells (DC) to these immune defense changes is not well understood. Alterations in DC numbers, dendropoiesis, and lifespan have not been specifically studied in vivo in chronic ethanol (EtOH) exposure models. As DC play an essential role in initiating immune responses, alterations in these DC characteristics would help expl… Show more

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Cited by 27 publications
(29 citation statements)
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“…This model has recently been proposed as mimicking human chronic alcohol use without liver disease (Cook et al, 2007). Consistent with this, there is lack of features of alcoholic liver disease but there are manifestations of immune alterations including innate and adaptive immune cell defects developing after various length of time of alcohol treatment (Cook et al, 2007; Edsen-Moore et al, 2008). …”
Section: Experimental Models Of Alcohol Administration and Their Clinmentioning
confidence: 67%
“…This model has recently been proposed as mimicking human chronic alcohol use without liver disease (Cook et al, 2007). Consistent with this, there is lack of features of alcoholic liver disease but there are manifestations of immune alterations including innate and adaptive immune cell defects developing after various length of time of alcohol treatment (Cook et al, 2007; Edsen-Moore et al, 2008). …”
Section: Experimental Models Of Alcohol Administration and Their Clinmentioning
confidence: 67%
“…Reduced numbers of DC in the spleen, but increased numbers in the thymus, are seen in mice given 20% ethanol in drinking water for up to 28 weeks [79]. These changes could not be ascribed to altered DC precursor numbers, differentiation or turnover rate.…”
Section: Macrophages: Impact On Chemokine Productionmentioning
confidence: 85%
“…However, it is likely that other defects within mice chronically consuming EtOH (such as IL-2 expression by CD4 T cells and defects within APCs) contribute to inappropriate and/or insufficient priming of IAV-specific CD8 T cells within dLN. Changes in antigen presenting cell populations have been well documented to occur during EtOH exposure (Fan et al, 2011, Ness et al, 2008, Parlet and Schlueter, 2013, Edsen-Moore et al, 2008, Legge and Waldschmidt, 2014, Gurung et al, 2009, Buttari et al, 2008, Happel and Nelson, 2005, Joshi and Guidot, 2007, Szabo and Mandrekar, 2009, Zhang et al, 2002, Eken et al, 2011, Joshi et al, 2005, Lau et al, 2007, Mehta and Guidot, 2012, Rendon et al, 2012, Siggins et al, 2009, Szabo and Mandrekar, 2008). While dendritic cell functionality during IAV challenge of mice chronically consuming EtOH has not been completely investigated, the migration of dermal DCs, cutaneous DCs and Langerhans cells is delayed following FITC sensitization (Ness et al, 2008, Parlet and Schlueter, 2013).…”
Section: Discussionmentioning
confidence: 99%