Effects of chronic dizocilpine on acute pain and on mRNA expression of neuropeptides and the dopamine and glutamate receptors

Al-Amin, Hassen; Saadé, Nayef E.; Khani, Munir; Atweh, Samir; Jaber, Mohamed

doi:10.1016/s0006-8993(03)02988-3

Cited by 21 publications

(13 citation statements)

References 38 publications

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“…This region shows upregulation of transcriptional activity during extinction of cocaine self-administration (Crespo et al 2001(Crespo et al , 2002 and MK-801 blocks transcriptional activity during extinction tests for analgesia (Al-Amin et al 2003). In conjunction with the present findings, this indicates that the piriform cortex is active during extinction of an operant that is NMDA receptor-dependent.…”

Section: Discussionsupporting

confidence: 82%

Dopamine-mediated MK-801-induced elevation in food-based extinction responding in rats and associated changes in region-specific phosphorylated ERK

2010

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Section: Discussionsupporting

confidence: 82%

Dopamine-mediated MK-801-induced elevation in food-based extinction responding in rats and associated changes in region-specific phosphorylated ERK

2010

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“…4, A and B), yet by itself, produced hyperalgesia, as previously reported in mice using the tail pinch test (50) and in rats using the hot plate assay (1). Furthermore, repeated MK-801 reduced the acute analgesic effect of morphine in the tail withdrawal assay but not the hot plate assay at 30 min after a morphine challenge without affecting baseline nociception at the time of testing (Fig.…”

Section: Discussionsupporting

confidence: 73%

“…This was done to eliminate any learning effect on the hot plate latencies to maximize the possibility for detecting a true MK-801-induced hyperalgesia (1). No significant differences were observed between days 2 and 3, so these values were averaged and presented as the baseline latency (0 min postinjection; Fig.…”

Section: Methodsmentioning

confidence: 99%

NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice

Bryant

Eitan²,

Sinchak

et al. 2006

American Journal of Physiology-Regulatory, Integrative and Comp

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Multiple studies demonstrate that coadministration of N-methyl-D-aspartate (NMDA) receptor antagonists with the opioid agonist morphine attenuates the development of analgesic tolerance. Sex differences in the effects of noncompetitive, but not competitive NMDA receptor antagonists on acute morphine analgesia, have been reported in mice, yet the role of sex in modulation of morphine tolerance by NMDA receptor antagonists has yet to be addressed. Therefore, we tested whether there is a sex difference in the effect of NMDA receptor antagonists on the development of morphine analgesic tolerance in C57BL/6J mice. Acutely, at a dose required to affect morphine tolerance in male mice, the noncompetitive NMDA receptor antagonist dizocilpine (MK-801) prolonged morphine analgesia similarly in both sexes in the hot plate and tail withdrawal assays. In the hot plate assay, coadministration of MK-801 or the competitive antagonist 3-(2-carboxpiperazin-4-yl)propyl-1-phosphanoic acid (CPP) with morphine attenuated the development of tolerance in male mice, while having no effect in females. Like normal and sham females, ovariectomized mice were similarly insensitive to the attenuation of morphine tolerance by MK-801 in the hot plate assay. Surprisingly, in the tail withdrawal assay, MK-801 facilitated the development of morphine-induced hyperalgesia and tolerance in males but not females. The results demonstrate that male mice are more sensitive to modulation of nociception and morphine analgesia after repeated coadministration of NMDA receptor antagonists. Furthermore, the underlying mechanisms are likely to be different from those mediating the sex difference in the modulation of acute morphine analgesia that has previously been reported.

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“…In tail flick, same doses of MK801 and NMDA did not have any effect because tail flick test response is a spinal reflex to thermal nociceptive stimulus and probably could measure antinociceptive effect of higher doses (13). Our results are in agreement with those of Nakama-Kitamura and Al-Amin et al who showed a dose dependent antinociceptive effect of MK801 in hot plate test in mice and rats, respectively (28,29). Moreover, other investigators reported that MK801 decreased abdominal contractions in acetic acid induced writhing in mice (30) and it abolished the visceral pain induced by noxious and non-noxious stimuli of colorectal distention in rats, indicating that MK801 analgesic activity is mediated through both central and peripheral mechanisms (31,32).…”

Section: Discussionsupporting

confidence: 94%

The Contribution of NMDA Receptors in Antinociceptive Effect of Pregabalin: Comparison of Two Models of Pain Assessment

et al. 2017

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Effects of chronic dizocilpine on acute pain and on mRNA expression of neuropeptides and the dopamine and glutamate receptors

Cited by 21 publications

References 38 publications

Dopamine-mediated MK-801-induced elevation in food-based extinction responding in rats and associated changes in region-specific phosphorylated ERK

Dopamine-mediated MK-801-induced elevation in food-based extinction responding in rats and associated changes in region-specific phosphorylated ERK

NMDA receptor antagonism disrupts the development of morphine analgesic tolerance in male, but not female C57BL/6J mice

The Contribution of NMDA Receptors in Antinociceptive Effect of Pregabalin: Comparison of Two Models of Pain Assessment

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