Effects of chronic administration of phencyclidine on stereotyped and ataxic behaviors in the rat

Smith, Robert C.; Biggs, Charles; Vroulis, George; Brinkman, Samuel D.

doi:10.1016/0024-3205(81)90694-9

Cited by 15 publications

(4 citation statements)

References 16 publications

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“…PCP, which is in agreement with several other studies (Greenberg and Segal, 1986;Leccese ef a/, 1986: Smith et al, 1981. Therefore, sensitization induced by PCP or MK-801 may not be due to a pharmacokinetic factor because a change in all behaviors induced by the drugs would be expected if pharmacokinetic lactors played a role in sensitization.…”

Section: Discussionsupporting

confidence: 91%

Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801

Domino

1994

Neurochemistry International

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Chronic administration of a psychomotor stimulant has been shown to produce progressively enhanced effects, a phenomenon called "reverse tolerance" or sensitization. Sensitization which develops to the psychomotor stimulant effect of a drug generalizes to drugs with similar neurochemical mechanisms of action, a phenomenon called cross-sensitization. The present study compared the psychomotor stimulant effects of phencyclidine and MK-801, examined the effects of the daily injection of phencyclidine and MK-801 on locomotor activity and investigated whether reciprocal cross-sensitization occurred between phencyclidine and MK-801. Adult female Sprague-Dawley rats were used. Their locomotor activity was measured automatically for a 2 h period following drug injection. Phencyclidine and MK-801 both increased locomotor activity. Four daily injections of phencyclidine in a dose of 3.2 mg/kg i.p., or MK-801 in a dose of 0.32 mg/kg i.p., produced sensitization to locomotor activity. Moreover, MK-801 sensitized rats showed cross-sensitization to phencyclidine. However, phencyclidine sensitized rats did not show cross-sensitization to MK-801. This finding suggests that there are significant differences in the neurochemical mechanisms underlying phencyclidine-induced and MK-801-induced sensitization. Phencyclidine sensitization may not be mediated by NMDA receptors.

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Section: Discussionsupporting

confidence: 91%

Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801

Domino

1994

Neurochemistry International

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“…Almost all the experiments on behavioral sensitization to PCP did not employ sufficient withdrawal of more than 24 h (Smith et al 1981;Greenberg and Segal 1986;Nabeshima et al 1987;Xu and Domino 1994). However, since the present work employed 4 days withdrawal, we can rule out the possibility of an acute action of the drug.…”

Section: Regimen Of Dosing Of Pcpmentioning

confidence: 76%

Effect of MS-153 on the development of behavioral sensitization to locomotion- and ataxia-inducing effects of phencyclidine

et al. 2002

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“…However, the disparity between the effects of ketamine compared to PCP and MK-801 in our study raises concerns over the value of generalised interpretation of results from such models that do not take these factors into account. A potential confound in these studies is previous drug history, as the behavioural responses caused by NMDAR antagonists can both tolerate and sensitise with repeated administration (Smith et al 1981;Castellani and Adams 1981;Nabeshima et al 1987;Xu and Domino 1994). Our study design diminished this concern, as the pseudorandom assignment of drug treatment groups per week generated a large number of permutations of individual drug history.…”

Section: Discussionmentioning

confidence: 97%

Diverse and often opposite behavioural effects of NMDA receptor antagonists in rats: implications for “NMDA antagonist modelling” of schizophrenia

et al. 2009

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Despite nominally common mechanisms of action and often presumed biological equivalence, the NMDA antagonists tested produced very diverse effects on the expression of instrumental action. Other aspects of responding were left intact, including switching and matching behaviours, and the ability to respond to conditional stimuli. The implications of such findings with regard to animal modelling of schizophrenic psychotic symptoms are manifold.

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Effects of chronic administration of phencyclidine on stereotyped and ataxic behaviors in the rat

Cited by 15 publications

References 16 publications

Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801

Asymmetric cross-sensitization to the locomotor stimulant effects of phencyclidine and MK-801

Effect of MS-153 on the development of behavioral sensitization to locomotion- and ataxia-inducing effects of phencyclidine

Diverse and often opposite behavioural effects of NMDA receptor antagonists in rats: implications for “NMDA antagonist modelling” of schizophrenia

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