Effects of Chronic Administration of Melatonin on Spatial Learning Ability and Long-term Potentiation in Lead-exposed and Control Rats

Cao, Xiu-Jing; Wang, Ming; Chen, Weiheng; Zhu, Da-Miao; She, Ji; Ruan, Di‐Yun

doi:10.1016/s0895-3988(09)60025-8

Cited by 28 publications

(26 citation statements)

References 22 publications

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“…Neonatal rats given low doses of melatonin exhibited impaired hippocampal LTP and displayed learning and memory deficits. Melatonin also exacerbated LTP impairments as well as learning and memory deficits induced by lead (77). Finally, in a study designed to assess if dark rearing (i.e., high levels of melatonin) affects hippocampal synaptic plasticity, melatonin administered early postnatally prevents the induction of LTP (408).…”

mentioning

confidence: 99%

“…This may seem surprising as it might be expected that an antioxidant should improve cognition rather than making it worse. However, these studies (77,92,139,318,393,408,430) were performed in the absence of excessive oxidative stress. Going back to the first part of this review, we described numerous studies indicating that ROS are important signaling molecules necessary for proper LTP induction, and therefore scavenging radicals with melatonin likely explains the detrimental effects of melatonin on synaptic plasticity.…”

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confidence: 99%

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Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad

Klann

2011

Antioxidants & Redox Signaling

478

350

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The brain is a metabolically active organ exhibiting high oxygen consumption and robust production of reactive oxygen species (ROS). The large amounts of ROS are kept in check by an elaborate network of antioxidants, which sometimes fail and lead to neuronal oxidative stress. Thus, ROS are typically categorized as neurotoxic molecules and typically exert their detrimental effects via oxidation of essential macromolecules such as enzymes and cytoskeletal proteins. Most importantly, excessive ROS are associated with decreased performance in cognitive function. However, at physiological concentrations, ROS are involved in functional changes necessary for synaptic plasticity and hence, for normal cognitive function. The fine line of role reversal of ROS from good molecules to bad molecules is far from being fully understood. This review focuses on identifying the multiple sources of ROS in the mammalian nervous system and on presenting evidence for the critical and essential role of ROS in synaptic plasticity and memory. The review also shows that the inability to restrain either age-or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memory function.

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confidence: 99%

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confidence: 99%

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad

Klann

2011

Antioxidants & Redox Signaling

478

350

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“…Under these conditions, it is possible that the animals have higher concentrations of melatonin than the others, as verified in Wistar rats 19 . This hormone inhibits Long-term potentiation (LTP) in the hippocampus 7,19 and in the cortex 9 in rodents. Thus, this hormone can impair learning in animals through inhibition of LTP, since Lashley III maze, beyond what is essentially a test of Another action of melatonin is that it causes an increase in concentration of the inhibitory neurotransmitter Gamma-aminobutyric acid (GABA) in the rat hypothalamus, cerebellum and cortex 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Many physiological processes which exhibit circadian variations, such as hormone secretions, could be the basis of these changes 3 . Melatonin, for example, has been shown to act as a modulator of particular cognitive functions [7][8][9][10] . As circadian rhythms are associated with the lighting environment, the effects on organisms caused by manipulations of lighting should be considered.…”

Section: Introductionmentioning

confidence: 99%

Learning and Working Memory In Mice Under Different Lighting Conditions

Ramos¹,

Murgas²,

Ferreira³

et al. 2013

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“…This outcome suggests that while the removal of the pineal gland and exogenous administration of melatonin via injections did impair learning performance, constant release melatonin administration via implantation did not affect the spatial memory in Wistar albino rats. There is also consistent research evidence that melatonin given from weaning did lead to learning and memory deficit in rats (Cao et al, 2009). Despite this new emerging evidence in the literature, there is more research needed for illuminating the role of the implementations on the various areas of the rat's brain.…”

Section: The Role Of Melatonin Hormone On Anxiety and Learning Performentioning

confidence: 96%