Effects of Chromium(III) Picolinate on Cortisol and DHEAs Secretion in H295R Human Adrenocortical Cells

Kim, Beob Gyun; Adams, Julye M; Lindemann, M. D.

doi:10.1007/s12011-009-8433-7

Cited by 6 publications

(6 citation statements)

References 38 publications

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“…Supplemental Cr has been demonstrated to reduce serum cortisol in pigs [25], guinea pigs [29], lambs [30], horses [31], calves [32], and humans [33]. In vitro, high concentration of Cr from Cr picolinate can directly inhibit cortisol secretion in agonist-stimulated adrenocortical cell line [34]. The present result is in line with these reports, indicating that Cr from CrNano may also have an "antistress" effect by lowering plasma cortisol.…”

Section: Discussionsupporting

confidence: 89%

Chromium(III) Nanoparticles Affect Hormone and Immune Responses in Heat-Stressed Rats

Zha

Zeng

Sun

et al. 2008

Biol Trace Elem Res

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This study was conducted to evaluate the effects of chromium nanoparticles (CrNano) on the hormone and immune responses of rats in heat stress condition. A total of 80 male Sprague-Dawley rats were randomly assigned to four dietary treatment groups (n = 20). The first group was offered a basal diet as a control. The second, third, and fourth groups received basal diet supplemented with 150, 300, and 450 microg/kg Cr, respectively, in the form of CrNano. At the end of the 8-week trial, growth performance, food utilization, and sera concentrations of hormones, immunoglobulins, and alexins were determined. Lymphocyte proliferation activity, antibody response to injected sheep red blood cells (SRBCs), and phagocytosis of peritoneal macrophages were determined by (3)H-thymidine uptake method, plaque-forming cells (PFC) assay, and ingesting chicken red blood cells test, respectively. The results indicated that rats that received CrNano exhibited no changes in growth rate and food efficiency compared to the control group. However, dietary supplementation of 150, 300, and 450 microg/kg Cr from CrNano significantly decreased serum concentrations of insulin and cortisol, increased sera levels of insulin-like growth factor I and immunoglobulin G, and enhanced the lymphoproliferative response, anti-SRBC PFC response, and phagocytic activity of peritoneal macrophages. These results suggest that dietary supplementation of Cr as CrNano affects hormone and immune status in heat-stressed rats.

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Section: Discussionsupporting

confidence: 89%

Chromium(III) Nanoparticles Affect Hormone and Immune Responses in Heat-Stressed Rats

Zha

Zeng

Sun

et al. 2008

Biol Trace Elem Res

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“…[47] tłumaczyli zastosowaniem mniejszych dawek i krótszej ekspozycji. Badania na ludzkich komórkach adrenokortykalnych (H295R) aktywowanych forskoliną wykazały hamujący wpływ pikolinianu chromu na uwalnianie kortyzolu [48].…”

Section: Chrom W Zaburzeniach Psychicznychunclassified

“…[47] oraz Kim i wsp. [48]), a w korze czołowej i móżdżku -znamiennie podwyższone stężenie serotoniny.…”

Section: Chrom W Zaburzeniach Psychicznychunclassified

Biological significance of chromium III for the human organism

Piotrowska¹,

Pilch²,

Tota³

et al. 2017

Med Pr

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Currently, chromium is probably the most controversial transition metal. In recent publications it is clearly stated that it is not an essential micronutrient and should be considered to have a pharmacological effect. Conflicting scientific reports along with a huge amount of dietary supplements, as well as dietary and sports nutrients available on the market have prompted the authors to investigate the available information on the range of possible application, efficacy and safety of products containing salts or chelates of chromium III. The authors reviewed articles in electronic databases for the years 1959-2016, and selected works describing the biochemical, physiological and toxic properties of chromium salts and chelates and the range of possible applications in medicine, dietetics and sport. A critical analysis of reports dealing with the effect of chromium on the carbohydrate and lipid metabolism, body composition, lean body mass and sports performance was carried out. The authors indicated papers analyzing the mechanism of action of chromium in the cognitive and affective disorders. Much attention has been paid to the safety use of chromium III supplements. There are still some unsolved issues. In the field of toxicology, a limited number of reports about environmental exposure to trivalent chromium in the workplace draws our attention. In the field of biochemical research, there is still a need to clarify the mechanism of psychiatric and endocrinological activity, especially in conjunction with the immune system. Med Pr 2018;69(2):211-223.

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“…In addition, cells can be collected for RNA extraction, which is further submitted to cDNA conversion and qRT-PCR. study effects of dietary chromium(III) picolinate on production of cortisol and dehydroepiandrosterone sulfate (DHEAS) [79]. In addition, adding exogenous hormones [e.g.…”

Section: Endocrine Disruption At Hormone-production Levelmentioning

confidence: 99%

In vitro bioassays for the study of endocrine-disrupting food additives and contaminants

Connolly

Ropstad

Verhaegen

2011

TrAC Trends in Analytical Chemistry

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Effects of Chromium(III) Picolinate on Cortisol and DHEAs Secretion in H295R Human Adrenocortical Cells

Cited by 6 publications

References 38 publications

Chromium(III) Nanoparticles Affect Hormone and Immune Responses in Heat-Stressed Rats

Chromium(III) Nanoparticles Affect Hormone and Immune Responses in Heat-Stressed Rats

Biological significance of chromium III for the human organism

In vitro bioassays for the study of endocrine-disrupting food additives and contaminants

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