2004
DOI: 10.1016/j.nut.2003.11.007
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Effects of chromium and copper depletion on lymphocyte reactivity to mitogens in diabetes-prone BHE/cdb rats

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Cited by 5 publications
(5 citation statements)
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“…The mechanism of Cr(III) interaction with other elements is unknown although such a relationship has been reported in animal studies. RHEE et al (2004) proved that in diabetic prone BHE/cdb rats Cr deficiency increased Zn content in the liver, while decreasing Cu tissue content and enhancing Mg and Fe accumulation in the liver.…”
Section: Results and Disscusionmentioning
confidence: 93%
“…The mechanism of Cr(III) interaction with other elements is unknown although such a relationship has been reported in animal studies. RHEE et al (2004) proved that in diabetic prone BHE/cdb rats Cr deficiency increased Zn content in the liver, while decreasing Cu tissue content and enhancing Mg and Fe accumulation in the liver.…”
Section: Results and Disscusionmentioning
confidence: 93%
“…After the SCI, animals in Group 1 (SCI plus supplements) received a daily dose (until euthanasia was performed) of the supplements intraperitoneally: Vitamin E (Alpha Tocopherol Acetate) 50 mg/kg diluted in 3.4 mL of olive oil 3537 and Zn 3 mg/kg 38 , Cu 6.5 mg/kg 32 and Se 0.2 mg/kg 39,40 diluted in 1 ml of PBS. In the case of groups 2 and 3, the rats received only the vehicle (PBS and olive oil per separate).…”
Section: Methodsmentioning
confidence: 99%
“…It has been reported that supplementation with Vitamin E, a potent antioxidant, and trace elements, such as Zinc (Zn), Selenium (Se), and Copper (Cu), improves the immune response. For example, Vitamin E increases lymphocyte proliferation in response to mitogens 25 ; Zn enhances phagocytic activity and antigen presentation to T-lymphocytes 26,27 ; Se and Cu increase T-cell differentiation and proliferative responses, superoxide dismutase, and IL-2 levels [28][29][30][31][32] . In view of these beneficial effects, it is relevant to evaluate the effect of such supplements to improve the immune system function after SCI.…”
Section: Introductionmentioning
confidence: 99%
“… 97 Appropriate amounts of chromium salts enhance T cell proliferation with the stimulation of mitogen concanavalin A (Con‐A) and phytohemagglutinin. 56 However, chromium (VI) is a toxic substance that induces apoptosis of thymocytes, leading to a reduction in thymocytes and thymic mass. 58 Exposure to chromate (VI) leads to a reduction of T cell numbers, and the expression of IFN‐γ, IL‐6, IL‐10 and IL‐17A.…”
Section: The Role Of Essential Trace Elementsmentioning
confidence: 99%
“…Chromium (III) salts, such as chromium poly nicotinic acid, chromium chloride, and chromium picolinate, have been used as nutritional supplements to affect the metabolism of sugars, proteins, and lipids 97 . Appropriate amounts of chromium salts enhance T cell proliferation with the stimulation of mitogen concanavalin A (Con‐A) and phytohemagglutinin 56 . However, chromium (VI) is a toxic substance that induces apoptosis of thymocytes, leading to a reduction in thymocytes and thymic mass 58 .…”
Section: The Role Of Essential Trace Elementsmentioning
confidence: 99%