Effects of chromium and copper depletion on lymphocyte reactivity to mitogens in diabetes-prone BHE/cdb rats

Rhee, Yeong; Burnham, Kim; Stoecker, Barbara J.; Lucas, Eduralin

doi:10.1016/j.nut.2003.11.007

Cited by 5 publications

(5 citation statements)

References 23 publications

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“…The mechanism of Cr(III) interaction with other elements is unknown although such a relationship has been reported in animal studies. RHEE et al (2004) proved that in diabetic prone BHE/cdb rats Cr deficiency increased Zn content in the liver, while decreasing Cu tissue content and enhancing Mg and Fe accumulation in the liver.…”

Section: Results and Disscusionmentioning

confidence: 93%

Dietary chromium(III) propionate complex supplementation affects tissue mineral levels in rats fed high-fructose diet

Król¹,

Krejpcio²

2012

J. Elem.

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Chromium(III) plays an important role in carbohydrate and lipid metabolism, thus supplements containing this element are broadly advertised as efficient agents improving blood glucose levels or even reducing body mass. However, their hypoglycemic potential depends on the chemical form, bioavailability, dosage and the duration of treatment. Chromium(III) supplementation is generally considered safe although some data point to interaction of this ion with other elements. Thus, the aim of this study was to evaluate the effect of chromium(III) supplementation on tissue mineral content in rats fed highfructose diets. Nine-week old male Wistar rats were fed ad libitum with a standard diet (control) or a high-fructose diet to induce insulin resistance. Next, supplementary dosages of chromium(III) propionate complex (1.0 and 5.0 mg Cr kg-1 b.w. day-1) were introduced and rats were fed those diets for 4 weeks. It has been found that supplementary chromium(III) did not affect tissue calcium, iron and zinc levels, but significantly increased hepatic magnesium and copper level, while decreasing splenic copper level in rats fed high-fructose diets. Higher chromium(III) dosages increased content of this element in kidneys. In conclusion, short-term supplementation of chromium(III) propionate complex affects mineral homeostasis in the tissues of rats fed high-fructose diets; however, the mechanisms of such interactions are only partially known.

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Section: Results and Disscusionmentioning

confidence: 93%

Dietary chromium(III) propionate complex supplementation affects tissue mineral levels in rats fed high-fructose diet

Król¹,

Krejpcio²

2012

J. Elem.

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“…After the SCI, animals in Group 1 (SCI plus supplements) received a daily dose (until euthanasia was performed) of the supplements intraperitoneally: Vitamin E (Alpha Tocopherol Acetate) 50 mg/kg diluted in 3.4 mL of olive oil 35–37 and Zn 3 mg/kg 38 , Cu 6.5 mg/kg 32 and Se 0.2 mg/kg 39,40 diluted in 1 ml of PBS. In the case of groups 2 and 3, the rats received only the vehicle (PBS and olive oil per separate).…”

Section: Methodsmentioning

confidence: 99%

“…It has been reported that supplementation with Vitamin E, a potent antioxidant, and trace elements, such as Zinc (Zn), Selenium (Se), and Copper (Cu), improves the immune response. For example, Vitamin E increases lymphocyte proliferation in response to mitogens 25 ; Zn enhances phagocytic activity and antigen presentation to T-lymphocytes 26,27 ; Se and Cu increase T-cell differentiation and proliferative responses, superoxide dismutase, and IL-2 levels [28][29][30][31][32] . In view of these beneficial effects, it is relevant to evaluate the effect of such supplements to improve the immune system function after SCI.…”

Section: Introductionmentioning

confidence: 99%

Supplementation With Vitamin E, Zinc, Selenium, and Copper Re-Establishes T-Cell Function and Improves Motor Recovery in a Rat Model of Spinal Cord Injury

et al. 2022

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Spinal cord injury (SCI) causes a dysfunction of sympathetic nervous system innervation that affects the immune system, leading to immunosuppression syndrome (ISS) and contributing to patient degeneration and increased risk of several infections. A possible therapeutic strategy that could avoid further patient deterioration is the supplementation with Vitamin E or trace elements, such as Zinc, Selenium, and Copper, which individually promotes T-cell differentiation and proliferative responses. For this reason, the aim of the present study was to evaluate whether Vitamin E, Zinc, Selenium, and Copper supplementation preserves the number of T-lymphocytes and improves their proliferative function after traumatic SCI. Sprague–Dawley female rats were subjected to moderate SCI and then randomly allocated into three groups: (1) SCI + supplements; (2) SCI + vehicle (olive oil and phosphate-buffered saline); and (3) sham-operated rats. In all rats, the intervention was initiated 15 min after SCI and then administered daily until the end of study. Locomotor recovery was assessed at 7 and 15 days after SCI. At 15 days after supplementation, the quantification of the number of T-cells and its proliferation function were examined. Our results showed that the SCI + supplements group presented a significant improvement in motor recovery at 7 and 15 days after SCI. In addition, this group showed a better T-cell number and proliferation rate than that observed in the group with SCI + vehicle. Our findings suggest that Vitamin E, Zinc, Selenium, and Copper supplementation could be part of a therapy for patients suffering from acute SCI, helping to preserve T-cell function, avoiding complications, and promoting a better motor recovery. All procedures were approved by the Animal Bioethics and Welfare Committee (Approval No. 201870; CSNBTBIBAJ 090812960).

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“… 97 Appropriate amounts of chromium salts enhance T cell proliferation with the stimulation of mitogen concanavalin A (Con‐A) and phytohemagglutinin. 56 However, chromium (VI) is a toxic substance that induces apoptosis of thymocytes, leading to a reduction in thymocytes and thymic mass. 58 Exposure to chromate (VI) leads to a reduction of T cell numbers, and the expression of IFN‐γ, IL‐6, IL‐10 and IL‐17A.…”

Section: The Role Of Essential Trace Elementsmentioning

confidence: 99%

“…Chromium (III) salts, such as chromium poly nicotinic acid, chromium chloride, and chromium picolinate, have been used as nutritional supplements to affect the metabolism of sugars, proteins, and lipids 97 . Appropriate amounts of chromium salts enhance T cell proliferation with the stimulation of mitogen concanavalin A (Con‐A) and phytohemagglutinin 56 . However, chromium (VI) is a toxic substance that induces apoptosis of thymocytes, leading to a reduction in thymocytes and thymic mass 58 .…”

Section: The Role Of Essential Trace Elementsmentioning

confidence: 99%

The roles of essential trace elements in T cell biology

Lan,

Feng,

Liu

et al. 2024

J Cellular Molecular Medi

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T cells are crucial for adaptive immunity to regulate proper immune response and immune homeostasis. T cell development occurs in the thymus and mainly differentiates into CD4+ and CD8+ T cell subsets. Upon stimulation, naive T cells differentiate into distinct CD4+ helper and CD8+ cytotoxic T cells, which mediate immunity homeostasis and defend against pathogens or tumours. Trace elements are minimal yet essential components of human body that cannot be overlooked, and they participate in enzyme activation, DNA synthesis, antioxidant defence, hormone production, etc. Moreover, trace elements are particularly involved in immune regulations. Here, we have summarized the roles of eight essential trace elements (iron, zinc, selenium, copper, iodine, chromium, molybdenum, cobalt) in T cell development, activation and differentiation, and immune response, which provides significant insights into developing novel approaches to modulate immunoregulation and immunotherapy.

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Effects of chromium and copper depletion on lymphocyte reactivity to mitogens in diabetes-prone BHE/cdb rats

Cited by 5 publications

References 23 publications

Dietary chromium(III) propionate complex supplementation affects tissue mineral levels in rats fed high-fructose diet

Dietary chromium(III) propionate complex supplementation affects tissue mineral levels in rats fed high-fructose diet

Supplementation With Vitamin E, Zinc, Selenium, and Copper Re-Establishes T-Cell Function and Improves Motor Recovery in a Rat Model of Spinal Cord Injury

The roles of essential trace elements in T cell biology

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