Effects of cholinergic and dopaminergic agents on pain and morphine analgesia measured by three pain tests

Dennis, Stephen G.; Melzack, Ronald

doi:10.1016/0014-4886(83)90166-8

Cited by 53 publications

(14 citation statements)

References 16 publications

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“…Relief of pain is rewarding [26,96,97]. Dennis and Melzack demonstrated that dopaminergic agents improve symptoms of pain and promote analgesia [98]. Studies have also shown that the VTA sends projections to the nucleus accumbens (NCs), limbic system (e.g., hippocampus and amygdala), and prefrontal cortex (e.g., mPFC, ACC, and OFC), forming the mesocorticolimbic system [27][28][29][30][31].…”

Section: Discussionmentioning

confidence: 99%

Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain

Ortiz

Gollub

et al. 2020

JCM

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Chronic low back pain (cLBP) is a common disorder with unsatisfactory treatment options. Acupuncture has emerged as a promising method for treating cLBP. However, the mechanism underlying acupuncture remains unclear. In this study, we investigated the modulation effects of acupuncture on resting state functional connectivity (rsFC) of the periaqueductal gray (PAG) and ventral tegmental area (VTA) in patients with cLBP. Seventy-nine cLBP patients were recruited and assigned to four weeks of real or sham acupuncture. Resting state functional magnetic resonance imaging data were collected before the first and after the last treatment. Fifty patients completed the study. We found remission of pain bothersomeness in all treatment groups after four weeks, with greater pain relief after real acupuncture compared to sham acupuncture. We also found that real acupuncture can increase VTA/PAG rsFC with the amygdala, and the increased rsFC was associated with decreased pain bothersomeness scores. Baseline PAG-amygdala rsFC could predict four-week treatment response. Our results suggest that acupuncture may simultaneously modulate the rsFC of key regions in the descending pain modulation (PAG) and reward systems (VTA), and the amygdala may be a key node linking the two systems to produce antinociceptive effects. Our findings highlight the potential of acupuncture for chronic low back pain management.

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Section: Discussionmentioning

confidence: 99%

Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain

Ortiz

Gollub

et al. 2020

JCM

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“…There are several potential mechanisms underlying the pathophysiological connection between TTH and PD. First, dopamine has been suggested to play a critical role in central pain modulation [ 28 ], and human neuroimaging studies have shown that pain processing involves dopamine D2 receptors [ 29 ]. Additionally, dopamine may modulate pain at different levels of pain processing, such as the spinal cord, thalamus, peri-aqueductal gray matter, basal ganglia, and cingulate gyrus [ 30 ].…”

Section: Discussionmentioning

confidence: 99%

Increased risk of Parkinson’s disease following tension-type headache: a nationwide population-based cohort study

et al. 2017

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PurposePrevious studies have suggested associations between primary headache and neurodegenerative diseases; however, the relationship between tension-type headache (TTH), which is the most common type of primary headache, and Parkinson's disease (PD) remains controversial. Hence, in this nationwide, population-based, retrospective cohort study, we explored the temporal association between TTH and PD.MethodsUsing claims data in the National Health Insurance Research Database of Taiwan, we evaluated 12,309 subjects aged ≥20 years who were newly diagnosed with TTH from 2000 to 2005. The non-TTH group included 49,236 randomly selected sex- and age-matched patients without TTH. Subjects were followed up until the end of 2011, diagnosis of PD, or death. The incidence of PD was compared between the two groups. A Cox multivariable proportional hazards model was used to calculate hazard ratios (HRs) and 95% confidence intervals (CIs) to estimate the risk of PD.ResultsThe overall incidence of PD (per 1,000 person-years) in the TTH and non-TTH groups was 3.01 and 1.68, respectively. After adjustment for sex, age, and comorbidities, the association between TTH and PD remained statistically significant (adjusted HR = 1.37, 95% CI = 1.19–1.57). The TTH group had a higher risk of PD than the non-TTH group did, regardless of subjects’ sex, age, and comorbidity status.ConclusionsThese findings demonstrate that patients diagnosed with TTH exhibit an increased risk of PD. Additional studies should investigate the potential shared pathophysiological mechanisms of TTH and PD. Clinicians should be aware that TTH is a potential risk factor for PD.

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“…The association between mesolimbic circuitry and neural substrates of pain and analgesia has been considered in the past decades [29; 37; 53]; for noxious or aversive conditions both excitatory and inhibitory responses of dopaminergic neurons have been observed [16; 23; 43; 50; 62; 68], both increases and decreases in extracellular dopamine are reported [11; 51], and corresponding results are found in human studies [44; 46]. Moreover, in patients with central disorders such as schizophrenia, Parkinson’s disease, substance abuse, and mood and anxiety disorders, pain sensitivity is altered, presumably as a consequence of changes in the dopaminergic system [1; 42; 71], and animal studies implicate dopamine in acute and neuropathic conditions [6; 26; 60]. Yet, the mechanistic role of NAc in pain chronification remains unknown.…”

Section: Introductionmentioning

confidence: 85%

Role of nucleus accumbens in neuropathic pain: Linked multi-scale evidence in the rat transitioning to neuropathic pain

Chang

Pollema-Mays

Centeno

et al. 2014

Pain

142

120

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Despite recent evidence implicating the nucleus accumbens (NAc) as causally involved in the transition to chronic pain in humans, underlying mechanisms of this involvement remain entirely unknown. Here we elucidate mechanisms of NAc reorganizational properties (longitudinally and cross-sectionally), in an animal model of neuropathic pain (spared nerve injury, SNI). We observed inter-related changes: 1) In resting-state fMRI, functional connectivity of the NAc to dorsal striatum and cortex was reduced 28 days (but not 5 days) after SNI; 2) contralateral to SNI injury, gene expression of NAc dopamine 1A, 2, and κ-opioid receptors decreased 28 days after SNI; 3) In SNI (but not sham) covariance of gene expression was upregulated at 5 days and settled to a new state at 28 days; and 4) NAc functional connectivity correlated with dopamine receptor gene expression and with tactile allodynia. Moreover, interruption of NAc activity (via lidocaine infusion) reversibly alleviated neuropathic pain in SNI animals. Together, these results demonstrate macroscopic (fMRI) and molecular reorganization of NAc and indicate that NAc neuronal activity is necessary for full expression of neuropathic pain-like behavior.

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Effects of cholinergic and dopaminergic agents on pain and morphine analgesia measured by three pain tests

Cited by 53 publications

References 16 publications

Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain

Acupuncture Treatment Modulates the Connectivity of Key Regions of the Descending Pain Modulation and Reward Systems in Patients with Chronic Low Back Pain

Increased risk of Parkinson’s disease following tension-type headache: a nationwide population-based cohort study

Role of nucleus accumbens in neuropathic pain: Linked multi-scale evidence in the rat transitioning to neuropathic pain

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