Increased risk of Parkinson’s disease following tension-type headache: a nationwide population-based cohort study

Yang, Fu-Chi; Chen, Hsuan-Ju; Lee, Jiunn‐Tay; Chen, Sy‐Jou; Sung, Yueh‐Feng; Kao, Chia‐Hung; Yang, Tse-Yen

doi:10.18632/oncotarget.23298

Cited by 6 publications

(11 citation statements)

References 48 publications

(50 reference statements)

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“…For example, two cohort studies suggest that migraine increases the risk of tinnitus and/or sudden deafness [8,9]. Patients with TTH were found to be at increased risk for Parkinson's disease [20]. Here, we show that non-migraine headache is associated with higher risks of tinnitus, sensorineural hearing impairment, and sudden deafness.…”

Section: Discussionsupporting

confidence: 48%

Risks of tinnitus, sensorineural hearing impairment, and sudden deafness in patients with non-migraine headache

et al. 2019

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Tinnitus and hearing impairment are prevalent among headache patients. This study aims to investigate the risk of tinnitus, sensorineural hearing impairment, and sudden deafness in patients with non-migraine headache. Participants included 43 294 patients with non-migraine headache (non-migraine headache cohort) and 173 176 patients with no headache of any type (control cohort) frequency-matched with respect to 10-year age interval and sex from the Longitudinal Health Insurance Database 2005 of the Taiwan National Health Insurance Research Database. The mean age of the non-migraine headache cohort was 28.4 ± 14.9 years, and 58.5% of this cohort was male. The incidence rates of tinnitus, sensorineural hearing impairment, and sudden deafness were compared between cohorts using the Kaplan–Meier method with the log-rank test. A Cox proportional hazard model was used to examine the association of tinnitus, sensorineural hearing impairment, and sudden deafness with non-migraine headache, with adjustment for all covariates. The combined risk of either tinnitus, sensorineural hearing impairment, or sudden deafness was higher in the non-migraine headache cohort than in the control cohort (adjusted odds ratio [aHR], 2.73; 95% confidence interval [95% CI], 2.62–2.84; p < 0.0001). Subgroup analysis showed that patients in the non-migraine headache cohort were at significantly higher risk of developing tinnitus (aHR, 3.05; 95% CI, 2.91–3.19; p < 0.0001), sensorineural hearing impairment (aHR, 1.89; 95% CI, 1.74–2.05; p < 0.0001), and sudden deafness (aHR, 2.14; 95% CI, 1.77–2.59; p < 0.0001) than were controls. In this population-based study, the risks of tinnitus, sensorineural hearing impairment, and sudden deafness were found to be significantly higher in patients with non-migraine headache than in those without headache.

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Section: Discussionsupporting

confidence: 48%

Risks of tinnitus, sensorineural hearing impairment, and sudden deafness in patients with non-migraine headache

et al. 2019

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“…The frequency of migraine among our patients (26%) was higher than what we would expect for elderly individuals (3 to 11%). 18 Individuals with migraine (migraine: Hazard Ratio = 1.46, 95% CI = 1.14-1.86 per year 19 20 ; migraine with aura: OR = 3.61, 95% CI = 2.7-4.8 21 ; migraine without aura: OR = 2.27, 95% CI = 1.5-3.5 21 ) and TTH (Hazard Ratio = 1.37, 95% CI = 1.19-1.57 per year) 19 are at higher risk of having PD than those without these kind of headaches. This can be explained through the shared pathophysiological mechanism of these conditions (dysfunction of the serotonergic and dopaminergic system) and through the higher oxidative stress that migraineurs present, which has been linked to presence of neurodegenerative disorders.…”

Section: Discussionmentioning

confidence: 99%

Parkinson’s Disease and Headaches: A Cross‐Sectional Study

Rocha-Filho

Souza-Lima

2020

Headache

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Objectives.-This study evaluated headaches among Parkinson's disease (PD) patients and whether there was any correlation between the motor symptoms and the severity of the headaches presented.Background.-Forty to 83% of PD patients are affected by pain. Despite this high prevalence of pain, only a few studies have addressed the headaches of these patients.Methods.-This was a cross-sectional study. Consecutive patients with Parkinson disease were included. Semi-structured interview; the Epworth sleepiness scale; the Hospital Anxiety and Depression Scale; the Unified Parkinson's Disease Rating Scale (UPDRS), Part III (motor examination); and the Hoehn and Yahr scale were used.Results.-About 46 patients were included, 52% were men, mean age was 66 ± 11 years. Forty-three patients had headaches, 12/46 (26%), migraines, 31/46 (67%) had tension-type headaches. We found no association between the headache frequency (median: 0.5; 0.5 to 7.5 vs 0.5; 0.5 to 8 days/3 months; P = .757) or intensity (median: 5; 4 to 8 vs 5.5, 4 to 9; P = .514) and the different stages of the PD (Hoehn and Yahr scale: ≤2.5 vs >2.5). There was no correlation between UPDRS score and the intensity (r = −0.099; P = .530) or frequency of headaches (r = −0.136; P = .373). No association was found between the grade of neck stiffness (0 vs 1 and 2 vs 3 and 4) and the headache frequency (Median: 0; 0 to 3 vs 3.5; 0 to 12.5 vs 0; 0 to 6 days/3 months; P = .074) or intensity (Median: 5; 3 to 9 vs 5; 4 to 6 vs 7; 4.5 to 9; P = .434). Twelve patients said that their headaches started after PD had been diagnosed. There was no difference regarding the frequency and characteristics of headaches and PD characteristics between these patients and the other patients with previous headaches.Conclusions.-In this sample of PD patients, there is no association between headache and PD.

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“…Finally, out of the 7 studies reporting association ratios, 5 presented OR while 2 presented hazard ratios (HR). Because the outcome (incident PD) was relatively rare in both of these cohorts (<<10%) [10,22], we considered HR and OR to be comparable and applied no transformation [23]. In all cases, we carried out random effects meta-analyses with the estimate of tau 2 being inferred from the iterative restricted maximum likelihood (REML) method.…”

Section: Discussionmentioning

confidence: 99%

“…None of the studies were an RCT. Two studies had sample sizes over 15,000 [22,27], while the other 10 had sample sizes below 1000…”

Section: Study Characteristicsmentioning

confidence: 99%

Migraine, Tension-Type Headache and Parkinson’s Disease: A Systematic Review and Meta-Analysis

et al. 2022

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Background and Objectives: The relationship between migraine and tension-type headache (TTH) with Parkinson’s disease (PD) is controversial, while a common pathophysiological link remains obscure. The aim of this systematic review is to investigate the association between PD, migraine and TTH. Materials and Methods: Following PRISMA, we searched MEDLINE, WebofScience, Scopus, CINAHL, Cochrane Library and ClinicalTrials.gov up to 1 July 2022 for observational studies examining the prevalence and/or associations of PD with migraine and TTH. We pooled proportions, standardized mean differences (SMD) and odds ratios (OR) with random effects models. The risk of bias was assessed with the Newcastle-Ottawa scale (PROSPERO CRD42021273238). Results: Out of 1031 screened studies, 12 were finally included in our review (median quality score 6/9). The prevalence of any headache among PD patients was estimated at 49.1% (760 PD patients; 95% CI 24.8–73.6), migraine prevalence at 17.2% (1242 PD patients; 95% CI 9.9–25.9), while 61.5% (316 PD patients; 95% CI 52.6–70.1) of PD patients with migraine reported headache improvement after PD onset. Overall, migraine was not associated with PD (302,165 individuals; ORpooled = 1.11; 95% CI 0.72–1.72).However, cohort studies demonstrated a positive association of PD among lifetime migraineurs (143,583 individuals; ORpooled = 1.54, 95% CI 1.28–1.84), while studies on 12-month migraine prevalence yielded an inverse association (5195 individuals; ORpooled = 0.64, 95% CI 0.43–0.97). Similar findings were reported by 3 studies with data on the TTH-PD relationship (high prevalence, positive association when examined prospectively and an inverse relationship on 12-month prevalence). These data were not quantitatively synthesized due to methodological differences among the studies. Finally, PD patients suffering from any headache had a lower motor unified Parkinson’s disease rating scale (UPDRS) score (503 PD patients; SMD −0.39; 95% CI −0.57 to −0.21) compared to PD patients not reporting headache. There is an unclear association of headaches in genetic PD cohorts. Conclusions: Observational data suggest that migraine and TTH could be linked to PD, but the current literature is conflicting.

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Increased risk of Parkinson’s disease following tension-type headache: a nationwide population-based cohort study

Cited by 6 publications

References 48 publications

Risks of tinnitus, sensorineural hearing impairment, and sudden deafness in patients with non-migraine headache

Risks of tinnitus, sensorineural hearing impairment, and sudden deafness in patients with non-migraine headache

Parkinson’s Disease and Headaches: A Cross‐Sectional Study

Migraine, Tension-Type Headache and Parkinson’s Disease: A Systematic Review and Meta-Analysis

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