Effects of Cholinergic Agonists and Antagonists under Conditions of Spleen Denervation in Rats with Endotoxic Shock

Abstract

Model experiments on rats with endotoxic shock induced by intraperitoneal injection of LPS Salmonella Typhi strain ty-4441 (20 mg/kg) showed that crossing of the vagus nerve innervating the spleen increased HR, stimulated production of antibodies, and moderated serotonergic activity of splenocytes. Pharmacological correction of the shock with muscarinic receptor antagonist atropine and its combinations with anticholinesterase agent galantamine or muscarinic and nicotinic cholinoreceptor agonist choline alfoscerate 30 min before shock modeling moderated HR and normalized B cell functions and serotonin level in the spleen.

Galantamine Attenuates Autoinflammation in a Mouse Model of Familial Mediterranean Fever

“…Previously, several disease models have shown that galantamine required an intact vagus nerve and expression of the α7-nAChR to elicit its anti-inflammatory actions [10,11,25]. To determine whether galantamine mediates its anti-inflammatory effects in FMF-KI mice via this pathway, we tested whether an intact vagus nerve and α7-nAChR expression were required for the actions of galantamine on FMF-KI splenomegaly.…”

Galantamine attenuates autoinflammation in a mouse model of familial mediterranean fever

“…Previously, several disease models have shown that galantamine required an intact vagus nerve and expression of the α7-nAChR to elicit its anti-inflammatory actions (Pavlov, et al 2009;Ji et al 2014;Sapronov et al 2010). To determine whether galantamine mediates its anti-inflammatory effects in FMF-KI mice via this pathway, we tested whether an intact vagus nerve and α7-nAChR expression were required for the actions of galantamine on FMF-KI splenomegaly.…”

Modulation of muscarinic receptors by anisodine hydrobromide in cerebral ischemia

“…The agonists and antagonists of muscarinic receptors in clinical shock may be closely associated with their regulation of the immune and nervous systems. For instance, research by Sapronov has shown that applying the cholinergic receptor antagonist atropine (ATP) 30 minutes before inducing a shock model can effectively alleviate heart rate irregularities, restore B cell function in the spleen, and regulate serotonin levels (13). Additionally, A.F.…”