Effects of Cholecalciferol Supplementation in Patients with stable heart failure and LOw vITamin D levels (ECSPLOIT-D): a double-blind, randomized, placebo-controlled pilot study

Turrini, Fabrizio; Scarlini, Stefania; Giovanardi, Paolo; Messora, Roberto; Rovedatti, L.; Chester, Johanna; Mussi, Chiara; Bertolotti, Marco; Trenti, Tommaso; Bondi, Mario

doi:10.23736/s0026-4725.17.04340-7

Cited by 9 publications

(5 citation statements)

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“…Overall, from the aforementioned clinical studies (summarized in the Table 1 (Ref. [42][43][44][45][46][47][48][49][50][51][52][55][56][57]) below), the efficacy and response to vitamin D supplementation is dependent on several factors and the extrapolation of some clinical endpoints and surrogate markers of heart disease to a beneficial effect of vitamin D is not conclusive. Therefore, some reservation may be exercised in the recommendation of vitamin D supplementation in heart failure under a vitamin D insufficient state and thus more large-scale studies are warranted.…”

Section: Study Population Methods Of Vitamin D Supplementation Outcom...mentioning

confidence: 99%

“…It was found that vitamin D supplementation in this patient population improved the 6-MWT, but only at 3 months of the supplementation period. Interestingly, an increase in left atrial size was observed in the placebo group [49]. In the VINDICATE study, which was a trial undertaken to investigate the effects of vitamin D on cardiac function in patients with chronic heart failure and vitamin D deficiency of <20 ng/mL [50], it was observed that supplementation with 4000 IU/day for 12 months did not improve 6-MWT.…”

Section: Role Of Vitamin D In Human Heart Failure: Current Evidence A...mentioning

confidence: 99%

“…Inconsistencies have been observed with respect to improvement in 6-MWT. In this regard, the ECSPLOIT-D study examined the effects of supplementation of vitamin D in patients with stable heart failure and a deficiency in serum levels of vitamin D of <20 ng/mL [49] . In this randomized, double-blind trial, the intervention group received 300,000 U loading dose of oral cholecalciferol followed by 50,000 U per month for 6 months.…”

Section: Role Of Vitamin D In Human Heart Failure: Current Evidence A...mentioning

confidence: 99%

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Understanding the Role of Vitamin D in Heart Failure

Tappia¹,

Lopez²,

Fitzpatrick‐Wong³

et al. 2023

Rev. Cardiovasc. Med.

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Vitamin D is now believed to have a significant role in cardiac signal transduction and regulation of gene expression, and thus influences normal cardiomyocyte function. It has been reported to provide cardioprotection through its anti-inflammatory, anti-apoptotic and antifibrotic actions; and to prevent cardiac remodeling, Ca 2+ -handling defects, and abnormal electrophysiological patterns. A vitamin D deficient state has been associated in the pathogenesis of heart failure; however, while many clinical studies report a benefit of vitamin D to heart function, other clinical studies are inconsistent with these findings. These uncertainties have led to a discord in the recommendation of vitamin D supplementation for the treatment of heart failure or as a preventive agent in patients deemed to be at risk for cardiac dysfunction. Accordingly, this article is intended to describe some of the mechanisms/sites of action of vitamin D in different animal models of heart failure, as well as to review the clinical observations and challenges in the interpretation and understanding of the clinical relevance of vitamin D in relation to heart function.

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Section: Study Population Methods Of Vitamin D Supplementation Outcom...mentioning

confidence: 99%

Section: Role Of Vitamin D In Human Heart Failure: Current Evidence A...mentioning

confidence: 99%

Section: Role Of Vitamin D In Human Heart Failure: Current Evidence A...mentioning

confidence: 99%

See 1 more Smart Citation

Understanding the Role of Vitamin D in Heart Failure

Tappia¹,

Lopez²,

Fitzpatrick‐Wong³

et al. 2023

Rev. Cardiovasc. Med.

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“…[4,5] In recent years, several randomized controlled trials (RCTs) have evaluated the effects of vitamin D supplementation in patients with chronic HF. [6][7][8][9][10][11][12][13][14][15][16] However, the results have been inconsistent and remain controversial.…”

Section: Introductionmentioning

confidence: 99%

Effect of vitamin D on endothelial and ventricular function in chronic heart failure patients: A prospective, randomized, placebo-controlled trial

Woo

Jang

et al. 2022

Medicine

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Background: Low 25-hydroxyvitamin D (25OHD) levels are common in patients with chronic heart failure (HF) and are associated with increased mortality risk. This study aimed to establish the safety and efficacy of oral vitamin D3 (cholecalciferol) supplementation and its effect on endothelial and ventricular function in patients with stable HF. Methods: This study was an investigator-initiated, multicenter, prospective, randomized, placebo-controlled trial. Seventy-three HF patients with 25OHD levels < 75 nmol/L (30 ng/mL) were randomized to receive 4000 IU vitamin D daily or a placebo for 6 months. The primary endpoint was a change in endothelial function between the baseline and after 6 months as assessed using EndoPAT. Secondary endpoints included changes in echocardiographic parameters and differences in quality of life (6-min walking test and New York Heart Association functional status) at 6 months. Results: There were no adverse events in either group during the study period. Vitamin D supplementation did not improve endothelial dysfunction (EndoPAT: baseline, 1.19 ± 0.4 vs 6 months later, 1.22 ± 0.3, P = .65). However, patients’ blood pressure, 6-min walking distance, and EQ-5D questionnaire scores improved after vitamin D treatment. In addition, a significant reduction in the left atrial diameter was observed. Conclusion: A daily vitamin D dose of 4000 IU for chronic HF appears to be safe. This dosage did not improve endothelial function but did improve the 6-min walk distance, symptoms, and left atrial diameter at 6 months.

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“…RCTs: Randomised control trials; Low Risk: (+); Unknown Risk: (! );[17][18][19][20][21][22][23][24][25][26][27][28][29] …”

mentioning

confidence: 99%

A Study of Vitamin D and Its Correlation With Severity and Complication of Congestive Heart Failure: A Systematic Review

Hazique¹,

Khan²,

Ramesh³

et al. 2022

Cureus

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Many studies have shown that vitamin D is a crucial modulator of hypertension and cardiovascular illness, including heart failure. Heart failure (HF) is still the leading cause of mortality worldwide. Patients with heart failure who have low vitamin D levels experience worse outcomes, which associate with known clinical correlations and biomarkers. Additionally, patients with low vitamin D levels are more likely to have diabetes, hypertension, atherosclerosis, and other precursor conditions to heart failure. There are some hints in recent experimental research on how vitamin D can have cardioprotective effects. Vitamin D supplementation might improve ventricular remodeling in heart failure patients, however, this is still unclear. It aims to evaluate the association between vitamin D and congestive heart failure (CHF). This systematic review used research from the previous ten years (January 2012-2022) retrieved from the following databases: PubMed/PMC (PubMed Central)/Medline and Cochrane Library. Using the Preferred Reporting Item for Systematic Review and Meta-analysis (PRISMA) 2020 guidelines, removing duplicates, screening of title and abstract, application of eligibility criteria, and quality appraisal, 13 articles were retained for systemic review. There were 10 randomized controlled trials and three observational studies. Vitamin D supplementation lowers serum inflammatory marker levels and improves the quality of life in CHF patients. Vitamin D treatment inhibits ventricular remodeling and improves cardiac function in a patient with CHF.

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Effects of Cholecalciferol Supplementation in Patients with stable heart failure and LOw vITamin D levels (ECSPLOIT-D): a double-blind, randomized, placebo-controlled pilot study

Cited by 9 publications

References 0 publications

Understanding the Role of Vitamin D in Heart Failure

Understanding the Role of Vitamin D in Heart Failure

Effect of vitamin D on endothelial and ventricular function in chronic heart failure patients: A prospective, randomized, placebo-controlled trial

A Study of Vitamin D and Its Correlation With Severity and Complication of Congestive Heart Failure: A Systematic Review

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