Effects of chlorpromazine on fear extinction.

Maintenance of self-attributed and drug-attributed behavior change.

“…The animals evidently have not learned that bar pressing is no longer associated with shock. Although the animal literature is by no means consistent (e.g., Miller, Murphy, & Mirsky, 1957;Nelson, 1967), it can be summarized by saying that the transfer of a drug-produced change in behavior to the nondrug state is often difficult to find.…”

Methods of deconditioning persisting avoidance: Amphetamine, chlorpromazine, and chlordiazepoxide as adjuncts to response prevention

“…Brady (1966) , Friedman (1966), and Kraft (1967) reported that snort-acting barbiturates, when used with desensitization therapy, helped remediate a variety of human phobias. Attempts, however , to facilitate RP using "relaxing" or "tranquilizing" drugs with laboratory animals have produced equivocal results (Nelson, 1967;Kamano, 1968;Baum, 1973), necessitating further research. This study was a test of three different drugs in rats with well-established avoidance .…”

Psychopharmacology

“…Reports that extinction of conditioned fear was facilitated (2, 67, 134) were not confi rmed by a well-controlled study (197) which suggested that the drug did not affect extinction processes when the exposure to the CS was held constant. However, an experiment by Barry & Miller (10) suggested that this effect was a func tion of differences in the intensity of the drive in the escape and avoidance tests.…”