Effects of Chlorpromazine and Bromolysergic Acid Diethylamide on Gastric Secretion of Acid Induced by Histamine in Rats

Amure, B. O.; Ginsburg, M.

doi:10.1111/j.1476-5381.1964.tb01706.x

Cited by 11 publications

(8 citation statements)

References 12 publications

(15 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Long-term treatment with AMG, however, does not seem either to increase the interdigestive secretion or to enhance the responses to injected histamine or gastrin in rats with whole stomach fistula, as can be seen from Table 1. This is contrary to the findings obtained with single doses of AMG (Ghosh & Schild, 1958;Amure & Ginsburg, 1964). It appears that the increase in blood histamine concentration under the influence of AMG is not sufficient to give a measurable increase in interdigestive acid secretion.…”

Section: Discussioncontrasting

confidence: 83%

Gastric secretion during pregnancy and lactation in the rat

Lilja¹,

Svensson²

1967

The Journal of Physiology

View full text Add to dashboard Cite

SUMMARY1. Gastric acid secretion has been studied in the rat before, during and after pregnancy using different types of stomach preparation. During the same periods the histamine-forming capacity (HFC) has been determined in gastric mucosa and mammary gland.2. In rats with a whole stomach fistula interdigestive acid secretion is increased during pregnancy and lactation.3. In rats with a denervated chronic pouch secretory response to stimulation with gastrin and histamine is augmented during pregnancy and lactation.4. The histamine forming capacity (HFC) of the gastric mucosa is increased 2-3 times during the last days of pregnancy and also during lactation.5. The HFC of the mammary gland is increased 2-3 times during lactation as compared with the fully developed gland in pregnancy.

show abstract

Section: Discussioncontrasting

confidence: 83%

Gastric secretion during pregnancy and lactation in the rat

Lilja¹,

Svensson²

1967

The Journal of Physiology

View full text Add to dashboard Cite

show abstract

“…Gastric acid secretion in the rat has been reported to be slightly inhibited by chlorpromazine (Amure & Ginsburg, 1964) but potentiated by aminoguanidine (Schayer, 1957b). These two actions are similar to those on the histidine decarboxylase activity of the acid-secreting portion (the pyloric portion) of the rat stomach.…”

Section: Discussionmentioning

confidence: 89%

The Effect of Aminoguanidine, Histamine, Chlorpromazine and Antibacterial Agents on Histidine Decarboxylase in the Stomach of the Rat

Radwan

West

1968

British Journal of Pharmacology and Chemotherapy

View full text Add to dashboard Cite

“…Thus, histamine methyltransferase could not be demonstrated in the oxyntic gland area of the rat stomach [5,6], but chiorpromazine and lysergic acid diethylamide enhanced both the histamine and gastrin stimulated gastric secretion in this species [7,8]. Furthermore, no significant activities of the diamine oxidase could be measured in the gastric mucosa of dogs and rats [6,9,10], but aminoguanidine augmented the histamine stimulated secretion in dogs [11] and the histamine and gastrin stimulated secretion in rats [7,8].These difficulties prompted us (1) to look for the enzymes, which were responsible for the inactivation of histamine in the gastric mucosa 1) Supported by grants from Deutsche Forschungsgemeinschaft (Lo 199/3) and E. Merck AG, Darmstadt. …”

mentioning

confidence: 97%

Augmentation of pentagastrin stimulated gastric secretion in the heidenhain pouch dog by amodiaquine: Inhibition of histamine methyltransferase in vivo?

et al. 1973

View full text Add to dashboard Cite

In 9 dogs, whose maximum gastric acid response to pentagastrin was evoked by 6 ~g/kg, the total gastric secretion as well as the peak gastric secretion was enhanced by amodiaquine. The optimum dose of this antimalarial drug was 2 mg/kg, whereas 0.25 mg/kg were without effect and 3 mg/kg reduced already the augmentation of gastric secretion by this substance. The increase in acid output by amodiaquine was greater than that in volume. The total secretion was more enhanced than the peak secretion, which means a longer duration of the amodiaquine potentiated gastric secretion elicited by pentagastrin, than that without application of amodiaquine contrary to that stimulated by exogenous histamine.Amodiaquine itself did not stimulate gastric acid secretion, in contrast to prostigmine and carbaehol. Thus amodiaquine seemed not to enhance gastric secretion by a direct or indirect parasympathomimetic action. The question whether amodiaquine acted on gastric secretion in a specific way and not by parasympathomimetic effects, led to investigations in several exocrine glands. In salivary glands, amodiaquine did neither stimulate the secretion in all doses investigated nor did it enhance the pilocarpine and acetylcholine induced salivation with any significance and regularity. Also the pancreatic and biliary secretion was neither stimulated by amodiaquine nor was the secretin induced secretion of the pancreas and liver augmented by amodiaquine. Thus the enhancing effect of this drug on the histamine and pentagastrin stimulated gastric secretion was very likely specific for the gastric mucosa and not due to a parasympathomimetic action of the drug.In contrast to the findings in various exocrine glands of the gastrointestinal tract, the arterial hypotension following the i.v. injection of acetylcholine was increased specifically by a preceeding i.v. injection of amodiaquine, whereas the equi-effective actions of histamine, serotonin and bradykinin as well as the hypertension by epinephrine and norepinephrine were not influenced by amodiaquine. This specific effect of the antimalarial drug very probably was not caused by an inhibition of the unspecific choline esterase in the blood.Since in exocrine glands no evidence could be found for a parasympathomimetic action or other modes of action of amodiaquine, it seemed probable that amodiaquine potentiated the histamine and pentagastrin stimulated gastric secretion by an inhibition of histamine methyltransferase in vivo.Although histamine was demonstrated in considerable concentrations in the gastric mucosa of numerous chordates, with the only exception of certain classes of fish [1] its physiological functions in the stomach are still unknown and hypotheses on this problem are the subject of many controversial communications [2][3][4]. The administration of inhibitors for the enzymatic inactivation of histamine in vivo was considered to be one possibility to find out the role histamine could play in gastric secretion. The interpretation, however, of the effects produced by ...

show abstract

Effects of Chlorpromazine and Bromolysergic Acid Diethylamide on Gastric Secretion of Acid Induced by Histamine in Rats

Cited by 11 publications

References 12 publications

Gastric secretion during pregnancy and lactation in the rat

Gastric secretion during pregnancy and lactation in the rat

The Effect of Aminoguanidine, Histamine, Chlorpromazine and Antibacterial Agents on Histidine Decarboxylase in the Stomach of the Rat

Augmentation of pentagastrin stimulated gastric secretion in the heidenhain pouch dog by amodiaquine: Inhibition of histamine methyltransferase in vivo?

Contact Info

Product

Resources

About