Effects of chlordane and methylmercury on the metabolism of carbaryl and carbofuran in rats

Lucier, George W.; McDaniel, Otelia S.; Williams, Carolyn D.; Klein, Ronald L.

doi:10.1016/0048-3575(72)90027-2

Cited by 24 publications

(6 citation statements)

References 25 publications

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“…Activity of hepatic glucuronyl transferase has been found to be unaffected in these studies (23). Methylmercury effects on microsomal drug-metabolizing capability may be attributable to an approximately 2-fold enhancement of CO-binding component degradation (22) and/or decrease in protein synthesis at the 10 mg/kg dose level (12).…”

Section: Endoplasmic Reticulum (Microsomal Enzyme Activities and Protmentioning

confidence: 99%

“…Administration of methylmercury to experimental animals has been found to reduce the activities of hepatic microsomal enzyme systems and cytocnrome P-450 content by approximately 50o following injected doses of 5 or 10 mg/kg (21)(22)(23). Activity of hepatic glucuronyl transferase has been found to be unaffected in these studies (23).…”

Section: Endoplasmic Reticulum (Microsomal Enzyme Activities and Protmentioning

confidence: 99%

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General subcellular effects of lead, mercury, cadmium, and arsenic.

Fowler¹

1978

Environ Health Perspect

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This working paper summarizes the known ultrastructural and biochemical effects of lead, mercury, cadmium, and arsenic on subcellular organeUle systems following in vivo administration. Documented metal-induced alterations in nuclear, mitochondrial, microsomal, and lysosomal functions are discussed in relation to their potential impact on cellular responses to other environmental agents. Each of the above elements has been found to interfere with normal cellular replication and genetic processes. Mitochondrial swelling and depression of respiratory function are discussed in relation to known metal-specific perturbations of mitochondrial heme biosynthetic pathway enzymes. Inhibition of microsomal enzyme activities and protein synthesis by lead and mercury is compared to the apparent absence of such effects following arsenic or cadmium exposure. Lysosomal uptake of all the metals is documented, but biochemical alterations in these structures have been reported for only mercury and cadmium. It is concluded that these toxic metals are capable of interacting with, and biochemicaly altering major cellular systems at dose levels below those required to produce signs of overt metal toxicity. The impact of these effects on cellular responses to other metals and xenobiotics in complex exposure situations is presently unknown, and further research is urgentiy needed in this area.

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Section: Endoplasmic Reticulum (Microsomal Enzyme Activities and Protmentioning

confidence: 99%

Section: Endoplasmic Reticulum (Microsomal Enzyme Activities and Protmentioning

confidence: 99%

General subcellular effects of lead, mercury, cadmium, and arsenic.

Fowler¹

1978

Environ Health Perspect

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show abstract

“…However, simultaneous treatment by these agents produced results similar to controls indicating the effects of the indi vidual agents were balanced out (158).…”

Section: Rats Fed Diets Containing a Mixture Of Dieldrin And Ddt Or Mmentioning

confidence: 73%

Interactions of Pesticides with Cytochrome P-450

Hodgson

Kulkarni

1974

Mechanism of Pesticide Action

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“…A mierosomal enzyme indueer, chlordane, and a mierosomal enzyme inhibitor, methylmercury, have been studied by LUCIER et al (1972) for their effect on carbaryl metabolism. Carbaryl oxidation was enhaneed by chlordane and decreased by methylmercury in vitro.…”

Section: A) Environmental Chemiealsmentioning

confidence: 99%

Carbaryl: A Literature Review

Mount

1981

Residue Reviews

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Effects of chlordane and methylmercury on the metabolism of carbaryl and carbofuran in rats

Cited by 24 publications

References 25 publications

General subcellular effects of lead, mercury, cadmium, and arsenic.

General subcellular effects of lead, mercury, cadmium, and arsenic.

Interactions of Pesticides with Cytochrome P-450

Carbaryl: A Literature Review

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