Effects of chitosan on the biological properties of gram-negative bacteria endotoxins

Abstract

The destructive action of Gram-negative bacteria lipopolysaccharides and their complexes with ehitosan, a natural polycation, was compared in vivo and in vitro. Lipopolysaceharides in complex with ehitosan modified the biological properties of endotoxin, among other things, reducing its toxic and aggregation effects.

Pathogenetic Role of Yersinia pseudotuberculosis Endotoxin in Hemostasis and Microcirculation Disturbances

“…Hemorrhagic rash and microhematuria are clinical symptoms of these disturbances. Sustained increase in coagulation potential of the blood is observed in 93% patients and in 50-70% patients these changes persist throughout the disease [7].…”

“…We previously studied im munogenic and immunomodulating properties of LPS from Y. pseudotuberculosis and demonstrated its role in the immunopathogenesis of pseudotuberculosis infection [5,6]; however, hemostasis disturbances caused by LPS remain poorly studied. Endotoxemia in pseudotuberculosis and other bacterial infections serves as a trigger factor of hemostasis disturbances [7]. Hemorrhagic rash and microhematuria are clinical symptoms of these disturbances.…”

Underscoring the immense potential of chitosan in fighting a wide spectrum of viruses: A plausible molecule against SARS-CoV-2?

“…Oligomer reported better inhibition for phage infections unlike anionic sulfate substituted groups which were ineffective against phage infection in contradiction with other viruses [ 50 ]. Positive charge on chitosan amino groups was cited to be a major contributor for the overall cationic property of chitosan and was suggested to be responsible for inactivation of phage infection and it was valid for plant viruses too [ 51 , 52 ]. Three major mechanisms were cited to be responsible for chitosan antiviral efficiency against phage infections.…”