Effects of Chinese herbs combined with in vitro fertilization and embryo transplantation on infertility: a clinical randomized controlled trial

Guo, Jia; Dong, Li; Liu, Cheng; Ji, Xiaolan; Li, Rong; Du, Xiaoguo

doi:10.1016/s0254-6272(14)60089-3

Cited by 15 publications

(8 citation statements)

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“…Chinese herbs and acupuncture are adjuvant therapies used for patients undergoing IVF [116,117] . Accumulating data suggest that Chinese herbs increase endometrial thickness and improve embryo quality, which may benefit IVF treatment.…”

Section: Traditional Chinese Medicinementioning

confidence: 99%

Use of biological and chemical molecules in regulating embryo implantation and endometrial receptivity

Chen

Sun

et al. 2022

Reproductive and Developmental Medicine

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This review summarizes the drugs and chemicals that may modulate embryo implantation. Non-hormonal molecules, including aspirin, improved endometrial blood flow, while low molecular weight heparin, vitamin E, sildenafil, and atosiban modulated the expression of endometrial genes. Hormonal factors, including human chorionic gonadotropin and growth hormones, can regulate the expression of endometrial receptivity markers. Other immunomodulatory molecules, including granulocyte colony-stimulating factor, peripheral blood mononuclear cells, autologous platelet-rich plasma, and intralipid and intravenous immunoglobulins, may improve implantation rate by modulating endometrial immune functions. Medicinal extracts of the Chinese herbs Paeonia lactiflora and Perilla frutescens increased the expression of leukemia inhibitory factors in endometrial epithelial cells. Recently, the use of the commercially available Library of Pharmacologically Active Compounds with a high-throughput screening method has provided an approach to screen for compounds that may potentially enhance or suppress embryo implantation. Whether these biomedical findings translate into clinical effects that enhance or suppress embryo implantation requires further investigation.

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Section: Traditional Chinese Medicinementioning

confidence: 99%

Use of biological and chemical molecules in regulating embryo implantation and endometrial receptivity

Chen

Sun

et al. 2022

Reproductive and Developmental Medicine

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“…As shown in Table 2, traditional herbal medicines have been used to treat female infertility [191]. Several reports have suggested that traditional herbal formulas and medicinal herbs successfully improve endometrial receptivity and might be an alternative option for improving the outcome of embryo implantation [192][193][194]. Many herbal formulas have been studied for enhancing the embryo implantation rate in animal studies and clinical study [195][196][197][198][199][200][201][202][203][204][205][206][207][208][209][210][211][212][213].…”

Section: Possible Role Of Autophagy On the Effect Of Medicinal Herbal Drugs As Embryo Implantation Enhancermentioning

confidence: 99%

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Park

Cho

et al. 2021

Pharmaceuticals

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Infertility is an emerging health issue worldwide, and female infertility is intimately associated with embryo implantation failure. Embryo implantation is an essential process during the initiation of prenatal development. Recent studies have strongly suggested that autophagy in the endometrium is the most important factor for successful embryo implantation. In addition, several studies have reported the effects of various natural products on infertility improvement via the regulation of embryo implantation, embryo quality, and endometrial receptivity. However, it is unclear whether natural products can improve embryo implantation ability by regulating endometrial autophagy. Therefore, we performed a literature review of studies on endometrial autophagy, embryo implantation, natural products, and female infertility. Based on the information from these studies, this review suggests a new treatment strategy for female infertility by proposing natural products that have been proven to be safe and effective as endometrial autophagy regulators; additionally, we provide a comprehensive understanding of the relationship between the regulation of endometrial autophagy by natural products and female infertility, with an emphasis on embryo implantation.

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“…However, it has been reported that CHM can increase endometrial thickness significantly, which is considered to favor conception. 7 CHM is broadly used for treating infertility, and clinical trials have been mostly positive, without ART or IVF. According to Ried, 8 40 randomized controlled trials (RCTs) involving 4247 women with infertility who were treated with CHM were reported in 2015; CHM improved pregnancy rates significantly, compared to drug therapy, boosting pregnancy rates from 30% to 60% over 3-6 months.…”

Section: Introductionmentioning

confidence: 99%

Acupuncture and Chinese Herbal Medicine Effects on Assisted Reproductive Technology: Six Cases and Their Clinical Significance

Jiang

Wan

et al. 2019

Medical Acupuncture

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Background: Assisted reproductive technology (ART) is the routine treatment for infertility. The success rate for individual sessions is generally not high, and many patients need to undergo several cycles. To increase their chances of success, many patients turn to acupuncture to complement ART. Many clinical trials of acupuncture helping in vitro fertilization (IVF) have focused only on IVF-embryo transfer (ET). In some difficult cases, when even IVF cannot be offered, acupuncture and Chinese herbs can improve the patients' conditions to reach a level at which ART can be successful. Cases: Six cases showed how acupuncture and Traditional Chinese Medicine (TCM), using Chinese herbs, can make IVF possible in difficult cases and how they can also help prevent miscarriage afterward. The cases included patients with amenorrhea, sperm disorders, polycystic ovary syndrome, diminished ovarian reserve (DOR), tubal blockage, premenopause, and premature ovarian insufficiency. Results: Acupuncture and Chinese herbs worked together to help make ART possible or easier. The ART used for these patients included intrauterine insemination, IVF, IVF with a donor egg, and introcytoplasmic sperm injection. In 3 cases, IVF was not initially successful but was successful after TCM treatment. Conclusions: These 6 cases demonstrated the positive effect of a combined approach, using acupuncture and herbs to reduce DOR and regulate hormonal disorders, creating sustainable environments for conceiving and maintaining pregnancy, thus, translating into clinical success. Clinical observation of these cases sheds new light on designing future clinical trials and practice of TCM for practitioners who provide infertility treatments.

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Effects of Chinese herbs combined with in vitro fertilization and embryo transplantation on infertility: a clinical randomized controlled trial

Cited by 15 publications

References 0 publications

Use of biological and chemical molecules in regulating embryo implantation and endometrial receptivity

Use of biological and chemical molecules in regulating embryo implantation and endometrial receptivity

Autophagy as a Therapeutic Target of Natural Products Enhancing Embryo Implantation

Acupuncture and Chinese Herbal Medicine Effects on Assisted Reproductive Technology: Six Cases and Their Clinical Significance

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