Effects of Chinese herbal medicine Yiqi Huaju Qingli Formula in metabolic syndrome patients with microalbuminuria: a randomized placebo-controlled trial

Tianzhan, Wang; Chen, Yu; He, Yanming; Xiao-dong, FU; Wang, Yi; Xu, Yawei; Yang, Hongjie; Hou, Xue; Liu, Yi; Feng, Xiaobing; Zhang, Teng; Wang, Wenjian

doi:10.3736/jintegrmed2013032

Cited by 25 publications

(19 citation statements)

References 22 publications

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“…The improvements in the experimental group was superior to the control group which only used chemical drugs. These results support the concept that integrative medicine has superior advantages in the prevention and treatment of metabolic syndrome, including addressing kidney damage by diabetes [9] .…”

Section: • Editorialsupporting

confidence: 79%

Enhancing the treatment of metabolic syndrome with integrative medicine

Wang

2013

Journal of Integrative Medicine

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Section: • Editorialsupporting

confidence: 79%

Enhancing the treatment of metabolic syndrome with integrative medicine

Wang

2013

Journal of Integrative Medicine

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“…Chronic kidney disease is characterized by progressive renal tissue fibrosis, and OPN may mediate the fibrotic process [19]. OPN is expressed at sites of calcification in human atherosclerotic plaques, emerging as an important inducible inhibitor of systemic calcification [18, 20], and may play a pivotal role in the progression of interstitial fibrosis in renal ischemia. However, the mechanism for OPN upregulation in kidney disease is not clear.…”

Section: Discussionmentioning

confidence: 99%

Protective Effects of Bu‐Shen‐Huo‐Xue Formula against 5/6 Nephrectomy‐Induced Chronic Renal Failure in Rats

Han

Chen

et al. 2014

Evidence-Based Complementary and Alternative Medicine

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Chronic renal failure (CRF) is a serious disease related to increasing incidence and prevalence as well as decline in quality of life. Bu-Shen-Huo-Xue formula (BSHX), one of traditional herbal formulations, has been clinically employed to treat CRF for decades, but the mechanisms involved have not been investigated. In the present study, we investigated the effects of BSHX on some closely related parameters in 5/6 nephrectomy CRF rats. Rats with CRF were divided into five groups, namely, one control group, one enalapril group, and three BSHX treatment groups (0.25, 0.5, and 1 g/kg·d). The rats subjected to sham operation were used as a normal control. After eight weeks of treatment, BSHX significantly decreased the levels of Scr and BUN, downregulated the mRNA expression levels of TGF-β 1, CTGF, NF-κB, TNF-α, and OPN, upregulated the mRNA expression of PPARγ, and reduced in situ expression of fibronectin and laminins. Histological findings also showed significant amelioration of the damaged renal tissue. BSHX protects 5/6 nephrectomy rats against chronic renal failure probably via regulating the expression of TNF-α, NF-κB, TGF-β 1, CTGF, PPARγ, OPN, fibronectin, and laminins and is useful for therapy of CRF.

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“…F.; 雷公藤) was shown to significantly decrease proteinuria and slow the decline of eGFR compared with valsartan . Some CHM prescriptions used to treat DKD have added effects of regulating blood lipids and decreasing blood glucose . Ongoing clinical trials will provide further evidence of the effectiveness of CHMs in treating DKD (Tangshen formula, ChiCTR‐TRC‐13003566; Shenyan Kangfu tablets, ChiCTR‐TRC‐12002182) …”

Section: Treating Diabetic Kidney Disease With Chinese Medicinementioning

confidence: 99%

“…14 Some CHM prescriptions used to treat DKD have added effects of regulating blood lipids and decreasing blood glucose. 15 Ongoing clinical trials will provide further evidence of the effectiveness of CHMs in treating DKD (Tangshen formula, ChiCTR-TRC-13003566; Shenyan Kangfu tablets, ChiCTR-TRC-12002182). 16 Abundance of studies on Chinese herbal medicines for diabetic kidney disease For this review, we searched the databases, PubMed, Cochrane Library, EMBASE, China National Knowledge Infrastructure, VIP Chinese journal database, Wanfang Database and Chinese Biomedical Literature Database, from inception until 15 August 2015.…”

Section: Clinical Efficacy Of Chm In Diabetic Kidney Diseasementioning

confidence: 99%