Chinese medicine for diabetic kidney disease in China

Abstract

Summary at a Glance This review summarizes the treatment of diabetic kidney disease (DKD) with Chinese herbal medicine (CHM) based on literature reports during the last 10 years. Commonly used CHMs and their underlying mechanisms are discussed.

ErHuang Formula Improves Renal Fibrosis in Diabetic Nephropathy Rats by Inhibiting CXCL6/JAK/STAT3 Signaling Pathway

“…Traditional Chinese Medicine (TCM) has been used for thousands of years for the treatment of a variety of disorders (Wen et al, 2017). This has led to clinical observations which have provided evidence of safety and efficacy of TCM usage including its use in the treatment of DN (Yan et al, 2016;Zhao et al, 2018).…”

Danhong injection for the treatment of early diabetic nephropathy

“…[ 3 ] Considering the high incidence of serious consequences when DN was progressed to end-stage, a great deal of interventions have been developed in order to effectively treat it when DN was identified at the early stage. [ 10 , 11 , 15 ] However, most of the interventions have not potential of preventing or reversing DN, so no optimal treatment option has been reported presently. [ 12 ] Although researchers and practitioners have also changed attentions from western medicine to traditional Chinese medicine, and a series of clinical studies and meta-analyses have also been performed to investigate the efficacy and safety of some Chinese medicines for the treatment of early DN, [ 6 , 14 , 15 ] it remains to be answered about optimal regime.…”

“…[ 14 ] Meanwhile, some of treatment regimes have also been suggested to be contraindicated for patients with severe renal impairment and have a set of serious side effects. [ 15 ] As a result, researchers and practitioners have changed their attention from western medicine alone to Chinese medicine alone or integrated regime of western and Traditional mediciness. [ 6 , 14 , 16 ]…”

Clinical efficacy and safety of Chinese herbal medicine for the treatment of patients with early diabetic nephropathy

“…[ 10 ] Present study shows that ACEI/ARB is contraindicated for patients with severe renal impairment and have a set of serious side effects. [ 11 ] Although the combination treatment with Chinese medicine and conventional western medicine is considered an effective approach to many conditions, herbal preparations are being preferred as assist therapy, because of their multiple targeted drug actions. [ 12 , 13 ]…”