Effects of chicory (Cichorium intybus L.) on nonalcoholic fatty liver disease

Faraji, Samira; Daneghian, Sevana; Alizadeh, Mohammad

doi:10.53388/tmr20200603192

Cited by 4 publications

(2 citation statements)

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“…Chicory is scientifically called Cichorium intybus and is one of the most important plants in the Asteraceae family 16 . Chicory is used in complementary and alternative medicine (CAM) to reduce gastrointestinal and liver disorders (such as non‐alcoholic fatty liver), polycystic ovary syndrome and diabetes 17‐19 . Recent evidence has shown that Chicory possesses pharmacological properties and multiple biological activities, including anti‐hyperglycaemic, anti‐hepatotoxic, anti‐inflammation, anti‐oxidation, antimicrobial, and hyperlipidaemia effects 19,20 .…”

Section: Introductionmentioning

confidence: 99%

“…16 Chicory is used in complementary and alternative medicine (CAM) to reduce gastrointestinal and liver disorders (such as non-alcoholic fatty liver), polycystic ovary syndrome and diabetes. [17][18][19] Recent evidence has shown that Chicory possesses pharmacological properties and multiple biological activities, including anti-hyperglycaemic, anti-hepatotoxic, anti-inflammation, anti-oxidation, antimicrobial, and hyperlipidaemia effects. 19,20 These various biological effects are resulting from some of the main medicinal compounds, including polyphenols, tannins, saponins, flavonoids, sesquiterpene, alkaloids, lactones, chlorophyll pigments, unsaturated sterols, coumarins, inulin and vitamins that are found in all parts of the plant.…”

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confidence: 99%

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A comprehensive mechanistic and therapeutic insight into the effect of chicory ( Cichorium intybus ) supplementation in diabetes mellitus: A systematic review of literature

Azgomi

Karimi

Tutunchi

et al. 2021

Int J Clinical Practice

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Background Cichorium intybus is a rich source of terpenoids and phenolic compounds, one of the effective methods in managing and reducing the complications of chronic diseases such as diabetes mellitus. The purpose of this systematic review was to evaluate the evidence obtained from animal and human studies on the effects of chicory on metabolic indicators (such as inflammation, oxidative stress, blood sugar and dyslipidaemia) of diabetes mellitus. Materials and methods This systematic search was performed in ProQuest, PubMed, Google Scholar, Scopus, Cochrane Central Register of Controlled Trials, Embase and Science Direct databases and on articles published until August 2021. All of the animal studies and clinical trials included in this systematic review that assessed the effect of chicory on metabolic risk markers in diabetes were published in English language journals. Results Finally, amongst 686 articles, only 23 articles met the needed criteria for further analysis. Out of 23 articles, 3 studies on humans and 20 studies on animals have been carried out. Fifteen of the 19 studies that evaluated the effect of chicory on the glycaemic index showed that Cichorium intybus improved blood glucose index (it had no effect in two human studies and three animal studies). Ten of the 13 studies evaluating the effect of Cichorium intybus on lipid profiles showed that it improved dyslipidaemia. Also, all 12 studies showed that chicory significantly reduces oxidative stress and inflammation. Conclusion According to the available evidence, Cichorium intybus might improve the glycaemic status, dyslipidaemia, oxidative stress and inflammation. However, further studies are recommended for a comprehensive conclusion about the exact mechanism of chicory in diabetic patients.

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Section: Introductionmentioning

confidence: 99%

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confidence: 99%

A comprehensive mechanistic and therapeutic insight into the effect of chicory ( Cichorium intybus ) supplementation in diabetes mellitus: A systematic review of literature

Azgomi

Karimi

Tutunchi

et al. 2021

Int J Clinical Practice

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Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

Siddiqa,

Qureshi,

Raja

et al. 2024

Front. Pharmacol.

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Background: Liver disease is a serious health concern in today’s world, posing a challenge to both healthcare providers and pharmaceutical companies. Most synthetic drugs and chemicals cause liver damage accounting for approximately 10% of acute hepatitis and 50% of acute liver failure.Purpose: The present study aimed to evaluate the hepato-protective activity of an extract of chicory formulation assisted by silver nanoparticles against carbon tetra chloride (CCl4)-induced hepatic damage in rat’s liver.Methods: Rats of the Wistar strain (Rattus norvegicus) were used to test the in vivo hepato-protective efficacy at various doses. Rats were randomly divided into nine groups, each containing six rats. The groups were as follows: first group (control), second group (CCl4), third group, silymarin (20 mg/kg of body weight), fourth group (CCl4+chicory) (1.75 mg/kg of b. wt), fifth group (CCl4 + chicory at the dose of 2.35 mg/kg), sixth group (CCl4 + chicory of 3.25 mg/kg), seventh group (CCl4 +AgNPs 1.75 mg/kg of b. wt.), eighth group (CCl4 + AgNPs 2.35 mg/kg of body weight), and ninth group (CCl4 + AgNPs 3.25 mg/kg of b. wt.). Blood samples were taken 24 h after the last administration (i.e., 30th day). The blood samples were analyzed for different serum enzymes such as ALP (alkaline phosphatase), ALT (alanine transaminase), bilirubin (Blr), triglyceride, and cholesterol. Histology liver sections were performed.Results: Treatment with AgNPs and chicory extract showed significant hepato-protective activity in a dose-dependent manner. In three doses, the chicory extract at a rate of 3.25 mg/kg of body weight significantly reduced elevated levels of biochemical markers in comparison to CCl4-intoxicated rats. Histology of the liver sections from CCl4-treated rats revealed inflammation of hepatocytes, necrosis, cytoplasmic degeneration, vacuolization, and a deformed central vein. The chicory formulation extract exhibited a remarkable recovery percentage in the liver architecture that was higher than the drug (i.e., silymarin). While treatment with AgNPs also repaired the degenerative changes and restored the normal form of the liver, chicory formulation extract possessed more hepato-protective potential as compared to AgNPs by regulating biochemical and histo-pathological parameters.Conclusion: This study can be used as confirmation of the hepato-protective potential of chicory compounds for possible use in the development programs of drugs to treat liver diseases.

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Clinical Efficacy of LivPro® Herbal Medicine among Hepatitis C Patients Pakistan: Longitudinal Interventional Study

Shahîd¹,

Khan²,

Khan³

et al. 2021

Arch. Pharm. Pract

261

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The current study aims to investigate the hepatoprotective effects of LivPro® among hepatitis C patients. An interventional study was performed among n=89 hepatitis C patients. The duration of the study was 3 months and the assessment for liver function, ELISA, and Viral load was performed monthly for the patients recruited in this study. Mean difference was measured and at a Confidence Interval (CI 95%) pvalue less than 0.05 was considered statistically significant. This interventional study was comprised of 89 patients who directly participated in this study. Of whom 52 (58.0%) were men and the remaining 42% were women. All the patients were hepatitis C positive at the time of recruitment of study. Overall, it is observed that improvement in ALT at the endpoint assessment was -23.13 [ -31.96 --14.30] in comparison to the baseline (p=<0.0001). Similarly, the improvement in AST and ALP was also significant (p=<0.0006; p=<0.0001). There was a significant decline in the Anti-HCV ELISA however, regardless of the decline the viral load was not found statistically significant at the end of the study. LivPro® is beneficial in improving the hepatic biomarkers of the patients suffering from Hepatitis C.

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Effects of chicory (Cichorium intybus L.) on nonalcoholic fatty liver disease

Cited by 4 publications

References 0 publications

A comprehensive mechanistic and therapeutic insight into the effect of chicory ( Cichorium intybus ) supplementation in diabetes mellitus: A systematic review of literature

A comprehensive mechanistic and therapeutic insight into the effect of chicory ( Cichorium intybus ) supplementation in diabetes mellitus: A systematic review of literature

Liver-boosting potential: chicory compound-mediated silver nanoparticles for hepatoprotection—biochemical and histopathological insights

Clinical Efficacy of LivPro® Herbal Medicine among Hepatitis C Patients Pakistan: Longitudinal Interventional Study

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