Effects of chicken-liver hydrolysates on lipid metabolism in a high-fat diet

Yang, Kuo Chung; Chen, Lin; Li, Chengwei; Chen, Yi‐Chen

doi:10.1016/j.foodchem.2014.03.052

Cited by 51 publications

(54 citation statements)

References 28 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Li et al (2011) stated that polysorbates can reduce serum total cholesterol and low-density lipoprotein levels in hyperlipidemic mice and rats. Yang et al (2014) indicated that improving the serum lipid profile, i.e., triglyceride and total cholesterol, is the most effective at decreasing liver lipid accumulation. These similar trends were observed in our study, which shown that the greater increase of HDL-C in SNE broilers after BS15 treatment, although there was no significant declination of TC and LDL-C in the BS15 group compared with the SNE group, and the TG was found same among all groups.…”

Section: Discussionmentioning

confidence: 99%

Preventing subclinical necrotic enteritis through Lactobacillus johnsonii BS15 by ameliorating lipid metabolism and intestinal microflora in broiler chickens

et al. 2017

View full text Add to dashboard Cite

Increasing studies have focused on the beneficial effects of Lactobacillus johnsonii in certain diseases. Here, we studied the prevention ability of a probiotic strain, L. johnsonii BS15 on subclinical necrotic enteritis (SNE), and its underlying mechanism. 180 male Cobb 500 chicks were randomly allotted into three groups and administrated with BS15 (1 × 106 cfu/g) or Man Rogosa Sharpe liquid medium throughout a 28-day experimental period. With the exception of the normal group, SNE infection was treated for the remaining experimental period after the chicks were fed with normal diet 14 days. Results showed that BS15 notably suppressed the SNE-induced loss of average daily gain and liver functional abnormality. Additionally, BS15 facilitated lipid metabolism of SNE boilers when the contents of peroxisome proliferator activated receptor γ and adipose triglyceride lipase in adipose tissue and serum high-density lipoprotein cholesterol decreased. BS15 also attenuated the hepatic lipid accumulation of stricken chicks by suppressing the genes expression of acetyl-CoA carboxylase, fatty acid synthase and sterol regulatory element binding protein-1c as well as stimulating the genes expression of peroxisome proliferator activated receptor α and carnitine palmitoyltransferase-1. Moreover, BS15 enhanced the development of SNE gut by improving the intestinal development and digestion as well as adjusting the gut microflora. Therefore, BS15 may provide a promising natural preventative strategy against SNE, which may be contributed to the amelioration of lipid metabolism and intestinal microflora.

show abstract

Section: Discussionmentioning

confidence: 99%

Preventing subclinical necrotic enteritis through Lactobacillus johnsonii BS15 by ameliorating lipid metabolism and intestinal microflora in broiler chickens

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Therefore, the antiobesity effects of this BV‐based supplement might result from its amino acid and Mg contents. Multiple studies have also reported that HFD‐induced obesity simultaneously results in hyperlipidemia and liver damage . It has been proposed that supplementing leucine or arginine can reduce serum cholesterol and triglyceride levels respectively.…”

Section: Discussionmentioning

confidence: 99%

“…Moreover, l ‐carnitine, synthesized from lysine and methionine, demonstrates an ameliorative effect of dyslipidemic and hepatic disorders of mice fed with an HFD . Similarly, a functional chicken liver hydrolysate – rich in leucine and arginine – has also shown a hypolipidemic effect in hamsters fed a high‐fat/cholesterol diet . Furthermore, there is a negative relationship between fecal lipid excretion and lipid levels in mice .…”

Section: Discussionmentioning

confidence: 99%

Modulation effects of black‐vinegar‐based supplement against a high‐fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy‐metabolism effects

Liu

Chou

et al. 2020

J Sci Food Agric

View full text Add to dashboard Cite

BACKGROUND An imbalanced fat or excess energy intake always results in obesity and increased serum/liver lipids, thus leading to metabolic syndromes. Given the bioactive components in black vinegar (BV), such as branched amino acids, phenolic profile, and mineral contents, we investigated the antiobesity effects of BV‐based supplements in rats fed a high‐fat diet (HFD). RESULTS HFD (30% fat, w/w) feeding increased (P < 0.05) body weight, weight gains, weights of livers and mesenteric, epididymal, and perirenal adipose tissues, and serum/liver triglyceride levels relative to those of rats fed a normal diet (4% fat, w/w; CON). These increased values were ameliorated (P < 0.05) by supplementing with BV‐based supplements but were still higher (P < 0.05) than those of CON rats. The increased areas of perirenal adipocytes in rats fed with an HFD were also decreased (P < 0.05) by supplementing with BV‐based supplements, which might result from an upregulation (P < 0.05) of 5′‐adenosine monophosphate‐activated protein kinase (AMPK), carnitine palmitoyltransferase‐1 (CPT1), and uncoupling protein‐2 (UCP2) in the perirenal adipose tissues. A similar effect was observed for AMPK, peroxisome proliferator‐activated receptor alpha, retinoid X receptor alpha, CPT1, and UCP2 gene and protein levels in livers (P < 0.05). Generally, BV‐based supplements increased the fecal triglyceride, cholesterol, and bile acid levels of rats fed with an HFD, which partially contribute to the lipid‐lowering effects. Furthermore, BV‐based supplements increased (P < 0.05) hepatic Trolox equivalent antioxidant capacity and lowered (P < 0.05) serum/liver thiobarbituric acid reactive substances values in HFD‐fed rats. CONCLUSION In a chronic high‐fat dietary habit, the food‐grade BV‐based supplement is a good daily choice to ameliorate obesity and its associated comorbidities. © 2020 Society of Chemical Industry

show abstract

“…On the other hand, OS supplementation on HFDfed rats can enhance the protein expression of uncoupling protein 2 (UCP-2), further increasing energy expenditure in electronic transport chain, and then attenuate the steatosis [42]. The UCP-2 was considered as an important therapeutic target in NAFLD [43], and many pharmacological researches had focused on related mechanisms to restore the lipid homeostasis [27,42,43,44]. Overall, the OSM or its metabolites may modulate the whole body lipid regulation.…”

Section: Discussionmentioning

confidence: 99%

Preventive Effects of Ophiocordyceps sinensis Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Chou¹,

Lin²,

Wu³

et al. 2017

JFNR

Self Cite

View full text Add to dashboard Cite

Dyslipidemia is regarded as one of risk factors related to cardiovascular disease and hepatosteatosis widely. Due to westernized diet habits and lifestyle changes, there is a high prevalence of those lipid-dysregulated diseases, i.e. fatty liver, hyperlipidemia, diabetes etc. However, the liver holds the lipid homeostasis so hepatoprotective nutraceuticals against high-fat diet (HFD) induced dyslipidemia may be potential for a public demand. This study demonstrated that OSM containing 10% polysaccharides and 0.25% adenosine can decrease (p<0.05) serum and liver triglyceride (TG) contents, and meanwhile, increased (p<0.05) fecal cholesterol (TC) levels in HFD fed mice. Moreover, Ophiocordyceps sinensis mycelium (OSM) also decreased (p<0.05) serum low-density lipoprotein cholesterol (LDLC) levels and the atherosclerosis index (LDLC/high-density lipoprotein cholesterol (HDLC)) in HFD fed mice. Regarding the liver damage, OSM supplementation attenuated serum aspartate aminotransferase (AST) and alanine aminotransferase (ALT) values, and liver tumor necrosis factor-α (TNF-α) levels in HFD fed mice. Taken together, OSM showed an ameliorative effect of the hepatosteatosis development and lipid-dysregulated-related diseases in a HFD habit.

show abstract

Effects of chicken-liver hydrolysates on lipid metabolism in a high-fat diet

Cited by 51 publications

References 28 publications

Preventing subclinical necrotic enteritis through Lactobacillus johnsonii BS15 by ameliorating lipid metabolism and intestinal microflora in broiler chickens

Preventing subclinical necrotic enteritis through Lactobacillus johnsonii BS15 by ameliorating lipid metabolism and intestinal microflora in broiler chickens

Modulation effects of black‐vinegar‐based supplement against a high‐fat dietary habit: antiobesity/hypolipidemic, antioxidative, and energy‐metabolism effects

Preventive Effects of <i>Ophiocordyceps </i><i>s</i><i>inensis </i>Mycelium on High-Fat Diet Induced Lipid Dysregulation and Hepatic Inflammation of Mice

Contact Info

Product

Resources

About