Effects of Chard (Beta Vulgaris L. Var. Cicla) on Cardiac Damage in Valproic Acid-Induced Toxicity

Abstract

The aim of this study was to examine the effects of chard on valproic acid (VPA)-induced cardiac damage. Female Sprague-Dawley rats were grouped as control, chard given control (100 mg/kg/day, by gavage), VPA (500 mg/kg/day, intraperitoneally) and chard given VPA (100 mg/kg/day chard by gavage, 500 mg/kg/day VPA, intraperitoneally). The aqueous extracts of chard leaves were given 1 h prior to administration of VPA for 7 days. Malondialdehyde (MDA), total sialic acid (SA) levels and catalase (CAT) activity significantly increased in the VPA group compared with the control group (P < 0.05). Chard administration significantly decreased MDA and SA levels in the control and in the VPA groups (P < 0.05). Chard administration also significantly increased CAT activities and glutathione levels both in the control and in the VPA groups (P < 0.05). As a conclusion, chard consumption may prevent cardiac tissue from oxidative stress and inflammation in VPA-induced toxicity.

Diyabetik Sıçan Karaciğerinde Pazı Ekstresinin Glikoprotein Bileşikleri ve İleri Oksidasyon Protein Ürün Seviyeleri Üzerindeki Koruyucu Etkisi

“…Chard (Beta vulgaris L. var cicla, chenopodiaceae family) is one of the vegetables grown widely in Turkey, North India, South America, Mediterranean countries, and the USA. Some studies have shown that chard extracts exhibit diverse biological effects, including anticancer and anti-inflammatory (9), antimicrobial (10), hepatoprotective (11), antioxidant and anti-acetylcholinesterase (12), and anti-diabetic (13,14) activities. These biological activities are closely associated with the phytochemical composition/content of chard.…”

“…These biological activities are closely associated with the phytochemical composition/content of chard. B. vulgaris is reported to contain some saponins, flavonoid glycosides (15), flavonoids, vitamin C, vitamin E, carotenoids and minerals (16), folic acid, phospholipid, glycolipid, and some fatty acids (11).…”

Alpha‐lipoic acid prevents brain injury in rats administered with valproic acid

“…[ 2 ] This information is also related to serious side and toxic effects of VPA on different organs and tissues of the body such as the liver, heart, kidney, small intestine, ocular tissue, nervous system, and brain. [ 3–8 ] The exact mechanism of VPA toxicity is still unknown, but the role of reactive oxygen species (ROS) is a well‐known reason for VPA toxicity. [ 9 ]…”

The possible hypo-lipidemic effect of aqueous extract of gamma-irradiated chard leaves in rats fed high fat diet

“…Feeding HFD for a long time may lead to the progression of diseases related to fatty liver such as nonalcoholic fatty liver disease, diabetes mellitus, Circulatory disorders such as heart failure and coronary heart disease [25]. Chard (Beta vulgaris) has widespread use in traditional medicine as a strong anti-oxidant, antiacetyl-cholinesterase, anti-diabetic, anti-tumor and hepato protective agent because it contains various natural components, such as carotenoids, some fatty acids, phospholipids, glycolipids, polysaccharides, folic acid, vitamins C and E, and poly-phenolic and thiol (SH) compounds [26].…”