Effects of cerebrolysin on motor-neuron-like NSC-34 cells

Enzymolysis kinetics, thermodynamics and model of porcine cerebral protein with single-frequency countercurrent and pulsed ultrasound-assisted processing

“…For this reason, the United States Department of Health recommends that limited amounts of these by-products be eaten, because of their associated health concerns [9]. However, there is a growing interest in the utilization and disposal of hydrolysates of porcine cerebral protein (PCP) which are used for the treatment of neural system diseases and prevents the age-dependent dementia [10], characterized by progressive loss of cognitive capability [11], and by pathological changes in the brain [12]. Indeed, one such product; Cerebrolysin (Ebewe Pharmaceutical, Austria), has been in clinical application for more than 40 years.…”

Effects and mechanism of cerebroprotein hydrolysate on learning and memory ability in mice

“…For example, it increases brain activity and is involved in oxidative processes in the body. It can also act on the central nervous system to regulate and improve the development and metabolism of neurons, induce the differentiation of neurons, promote the formation of synapses, and protect nerve cells from damage caused by ischemia, hypoxia, and neurotoxins (Sharp, 2002;Keilhoff et al, 2014). In addition, cerebroprotein hydrolysate can affect the respiratory chain by increasing the utilization of oxygen and glucose in the brain, subsequently, increasing the antioxidant capacity of brain tissues and the ability of the body to handle stress, improving energy metabolism in the brain, alleviating damage to brain tissues, and promoting recovery of brain function.…”

Peptide profiling of Internet‐obtained Cerebrolysin using high performance liquid chromatography – electrospray ionization ion trap and ultra high performance liquid chromatography – ion mobility – quadrupole time of flight mass spectrometry

“…[7] Furthermore, inconsistency about the identity and origin of the peptides present in the drug is an issue and results in questions about the product's quality. It is stated that Cerebrolysin contains peptides from digested porcine brain [8][9][10] or digested porcine brain proteins, [7,11,12] but also neuropeptides, [13][14][15][16] fragments of known neurotrophic factors (like NGF) and peptides (enkephalin, orexin, and galanin) [17] or even unprocessed neurotrophic factors like BDNF [18] are mentioned to be the active components of Cerebrolysin.…”

“…The product, first developed in Russia a few decades ago, is claimed to have a positive effect on various central disorders like ischemic stroke and vascular dementia. [7,19] In vitro experiments on cells, [8,9,11] as well as in vivo animal experiments [14,15,17,18,[20][21][22][23][24][25][26][27][28][29] and human clinical trials, [12,13,16,[30][31][32][33][34][35][36] report various effects, with a high number of results written in Russian and published in local journals [10,17,[22][23][24][30][31][32][33][34][35][36][37][38][39] ; several other studies are sponsored by or done in collaboration with the manufacturer. [8,14,26,28,…”