Effects of centrophenoxine on the lipofuscin pigments in the nervous system of old rats

Riga, Sorin; Riga, Dan

doi:10.1016/0006-8993(74)90864-6

Cited by 63 publications

(30 citation statements)

References 12 publications

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“…Brain LP and CP inhibition, decrease, dissolution and elimination by therapeutical means were investigated using different morphological methodologies: light microscopy and histochemistry [8,9,11,12,15,17,19], autofluorescence properties [9,11,12,19,22,23], electron microscopy [7,12,15,16,18,20,21] and morphometric techniques at light, fluorescent and electron microscopic levels [9, 11-14, 19, 21-23, 40], Only two quantitative researches using fluorescence morphometry [10,24] invalidated the meclofenoxate therapeutical ability to LP diminution in the aging brains.…”

Section: Methodsmentioning

confidence: 99%

“…Neuroblastoma cells in culture [11], rat cerebral hemisphere in primary culture [12], mouse [13], rat [9,14,15], guinea pig [8,16] and monkey [7,17] aging brains were used to demonstrate the lipofuscinolytic and ceroidolytic activity of meclofenoxate. Rat brains were studied for LP and CP inhibition, decrease and dissolution by orotic acid administered as derivatives [14,18] or in combinations [19,20], Rat aging brains were analysed in connection with LP lysis and CP lysis properties of Antagonic-Stress -an anti-aging and anti-stress synergistic therapeutic formula [19,20], Brains from rats with long-term alcohol intoxication were investigated in relation to LP and CP diminution by piracetam [21].…”

Section: Methodsmentioning

confidence: 99%

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Brain Lipofuscinolysis and Ceroidolysis -to Be or Not to Be

Riga¹,

Riga²

1995

Gerontology

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Lipofuscin pigment (LP) accumulations and ceroid pigment (CP) storages were demonstrated by multiple consensus studies. On the contrary, fewer researches, sometimes with opposite conclusions were made on brain LP and CP decrease, dissolution and elimination. Neuroactive agents (such as Meclofenoxate, Orotic acid, Antagonic-Stress, Piracetam, L-Deprenyl, Geriforte) generate LP and CP decrease and dissolution by cytoplasm rehydration, optimization of the brain cellular recycling system activities, by neuronal, glial and capillary LP lysis and CP lysis, by neurono-glio-endothelial transfer of highly processed LP and CP, with final capillary elimination. Therefore, these nootropic drugs may become therapeutical solutions in brain aging deceleration, in CP inductive circumstances and in age-associated diseases.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Brain Lipofuscinolysis and Ceroidolysis -to Be or Not to Be

Riga¹,

Riga²

1995

Gerontology

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“…Intraneuronal lipofuscin accumulation in the cerebral hemispheres of the control and diabetic treated rats were observed in 5 micron thick paraffin embedded, deparaffinised sections according to the method of Riga and Riga (1974) and used by Kumar et al (2012a) by fluorescence microscopy using a Zeiss Orthomat microscope equipped with fluorescence attachments with Ploemipak Epi illuminator, H2 cube (wide band), and exciter filter 390-490 nm was used.…”

Section: Histochemical Localization and Distribution Of Neurolipofuscinmentioning

confidence: 99%

Sodium Orthovanadate and Trigonella Foenum Graecum Prevents Neuronal Parameters Decline and Impaired Glucose Homeostasis in Alloxan Diabetic Rats

Kumar¹,

Taha²,

Kumar³

et al. 2015

Prague Med. Rep.

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Kumar P.; Taha A.; Kumar N.; Kumar V.; Baquer N. Z. Report / Vol. 116 (2015) 122) Prague Medical Key words: Alloxan diabetes -Monoamine oxidase (MAO) -Ca2+ ATPaseAcetylcholinesterase (AChE) -Neurolipofuscin -Sodium orthovanadate (SOV) -Trigonella foenum graecum seed powder (TSP) Abstract: Hyperglycemia is the most important contributor in the onset and progress of diabetic complications mainly by producing oxidative stress. The present study was carried out to observe, the antihyperglycemic effect of sodium orthovanadate (SOV) and Trigonella foenum graecum seed powder (TSP) administration on blood glucose and insulin levels, membrane linked enzymes (monoamine oxidase, acetylcholinesterase, Ca 2+ ATPase), intracellular calcium (Ca 2+ ) levels, lipid peroxidation, membrane fluidity and neurolipofuscin accumulation in brain of the alloxan induced diabetic rats and to see whether the treatment with SOV and TSP was capable of reversing the diabetic effects. Diabetes was induced by administration of alloxan monohydrate (15 mg/100 g body weight) and rats were treated with 2 IU insulin, 0.6 mg/ml SOV, 5% TSP in the diet and a combination of 0.2 mg/ml SOV and 5% TSP separately for three weeks. Diabetic rats showed hyperglycemia with almost four fold high blood glucose levels. Activities of acetylcholinesterase and Ca 2+ ATPase decreased in diabetic rat brain. Diabetic rats exhibited an increased level of intracellular Ca 2+ levels, lipid peroxidation, 123)Prague Medical Report / Vol. 116 (2015) No. 2, p. 122-138 neurolipofuscin accumulations and monoamine oxidase activity. Treatment of diabetic rats with insulin, TSP, SOV and a combined therapy of lower dose of SOV with TSP revived normoglycemia and restored the altered level of membrane bound enzymes, lipid peroxidation and neurolipofuscin accumulation. Our results showed that lower doses of SOV (0.2 mg/ml) could be used in combination with TSP in normalization of altered metabolic parameters and membrane linked enzymes without any harmful side effect.

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“…A number of neuro tropic (antipsychotic) drugs with 'membranestabilizing' properties have been evaluated in animals and, in some cases, dramatic changes in behavior and life-span were noted (14,15). Of additional significance is the fact that injections of dimethylaminoethyl p-chlorophenoxy acetate (also known as centrophenoxine and meclofenoxate) (1,10,13,16) and prolonged admin istration of the neuroleptic (antipsychotic) drug chlorpromazine (14), substantially reduced age pigment concentrations in the neurons of senile animals.…”

Section: Introductionmentioning

confidence: 99%

Dihydroergotoxine (Hydergine®) and Ethanol-Induced Aging of C57BL/6J Male Mice

Samorajski¹,

Rolsten²,

Pratte³

1978

Pharmacology

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The residual effects of dihydroergotoxine (Hydergine®), ethanol, and Hydergine-plus-ethanol were investigated in old male mice of the C57BL/6J strain. Prolonged 10% v/v ethanol, concomitant with adequate nutrition, produced a significant decrease in life-span, decreased spontaneous locomotor activity and reduced lipofuscin accumulation in neurons of the reticularis gigantocellularis. These effects were not apparent in mice treated with Hydergine or alcohol combined with Hydergine.

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Effects of centrophenoxine on the lipofuscin pigments in the nervous system of old rats

Cited by 63 publications

References 12 publications

Brain Lipofuscinolysis and Ceroidolysis -to Be or Not to Be

Brain Lipofuscinolysis and Ceroidolysis -to Be or Not to Be

Sodium Orthovanadate and Trigonella Foenum Graecum Prevents Neuronal Parameters Decline and Impaired Glucose Homeostasis in Alloxan Diabetic Rats

Dihydroergotoxine (Hydergine®) and Ethanol-Induced Aging of C57BL/6J Male Mice

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Effects of centrophenoxine on the lipofuscin pigments in the nervous system of old rats

Cited by 63 publications

References 12 publications

Brain Lipofuscinolysis and Ceroidolysis -to Be or Not to Be

Brain Lipofuscinolysis and Ceroidolysis -to Be or Not to Be

Sodium Orthovanadate and Trigonella Foenum Graecum Prevents Neuronal Parameters Decline and Impaired Glucose Homeostasis in Alloxan Diabetic Rats

Dihydroergotoxine (Hydergine&reg;) and Ethanol-Induced Aging of C57BL/6J Male Mice

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Dihydroergotoxine (Hydergine®) and Ethanol-Induced Aging of C57BL/6J Male Mice