Effects of Cefazolin and Meropenem in Eradication Biofilms of Clinical and Environmental Isolates of Proteus mirabilis

Silva, Sivoneide; Araújo, Lívia Caroline Alexandre de; Nascimento, José Adelson Alves do; Silva, Túlio; Lópes, Ana Catarina de Souza; Correia, Maria T.S.; Silva, Márcia; Oliveira, Maria Betânia Melo de

doi:10.1007/s00284-020-01984-7

Cited by 3 publications

(1 citation statement)

References 33 publications

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“…mirabilis, although P. mirabilis has a negatively charged hydrophilic cell surface. ,− Hence, the static system facilitated more time for the TFP–PDMS surface to be attached to more oleophilic compounds as a binder of calcium and magnesium particles. Because silicone was moderately hydrophobic and moderately oleophobic, silicone exhibited resistance to both types of compounds that resulted in poor deposition of calcium and magnesium.…”

Section: Resultsmentioning

confidence: 99%

Reduced Crystalline Biofilm Formation on Superhydrophobic Silicone Urinary Catheter Materials

et al. 2021

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Crystalline biofilm formation in indwelling urinary catheters is a serious health problem as it creates a barrier for antibacterial coatings. This emphasizes the failure of antibacterial coatings that do not have a mechanism to reduce crystal deposition on catheter surfaces. In this study, trifluoropropyl spray-coated polydimethylsiloxane (TFP–PDMS) has been employed as an antibiofilm forming surface without any antibacterial agent. Here, TFP was coated on half-cured PDMS using the spray coating technique to obtain a durable superhydrophobic coating for a minimum five cycles of different sterilization methods. The crystalline biofilm-forming ability of Proteus mirabilis in artificial urine, under static and flow conditions, was assessed on a TFP-PDMS surface. In comparison to the commercially available silver-coated latex and silicone catheter surfaces, TFP–PDMS displayed reduced bacterial attachment over 14 days. Moreover, the elemental analysis determined by atomic absorption spectroscopy and energy-dispersive X-ray analysis revealed that the enhanced antibiofilm forming ability of TFP-PDMS was due to the self-cleaning activity of the surface. We believe that this modified surface will significantly reduce biofilm formation in indwelling urinary catheters and further warrant future clinical studies.

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Section: Resultsmentioning

confidence: 99%

Reduced Crystalline Biofilm Formation on Superhydrophobic Silicone Urinary Catheter Materials

et al. 2021

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Approaches to enhance the antimicrobial activity of carbapenems within bacterial biofilms

Lamb,

Wiedbrauk,

Fairfull-Smith

2024

RSC Pharm.

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Investigation of factors related to biofilm formation in Providencia stuartii

Silva

Ramos

Sá

et al. 2022

An. Acad. Bras. Ciênc.

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Providencia stuartii is one of the Enterobacteriaceae species of medical importance commonly associated with urinary infections, which can also cause other ones, including uncommon ones, such as liver abscess and septic vasculitis.This bacterium stands out in the expression of intrinsic and acquired resistance to antimicrobials. Besides, it uses mechanisms such as biofi lm for its persistence in biotic and abiotic environments. This study investigated the cellular hydrophobicity profi le of clinical isolates of P. stuartii. It also analyzed genes related to the fi mbrial adhesin in this species comparing with other reports described for other bacteria from Enterobacteriaceae family. The investigated isolates to form biofi lm and had a practically hydrophilic cell surface profi le. However, fi mH and mrkD genes were not found in P. stuartii, unlike observed in other species of Enterobacteriaceae. These results show that P. stuartii has specifi cities regarding its potential for biofi lm formation, which makes it diffi cult to destabilize the infectious process and increases the permanence of this pathogen in hospital units.

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Effects of Cefazolin and Meropenem in Eradication Biofilms of Clinical and Environmental Isolates of Proteus mirabilis

Cited by 3 publications

References 33 publications

Reduced Crystalline Biofilm Formation on Superhydrophobic Silicone Urinary Catheter Materials

Reduced Crystalline Biofilm Formation on Superhydrophobic Silicone Urinary Catheter Materials

Approaches to enhance the antimicrobial activity of carbapenems within bacterial biofilms

Investigation of factors related to biofilm formation in Providencia stuartii

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