Effects of catalase, peroxidase, superoxide dismutase and 10 scavengers of oxygen radicals in carrageenin edema and in adjuvant arthritis of rats

Hirschelmann, R; Bekemeier, H

doi:10.1007/bf01948381

Cited by 47 publications

(23 citation statements)

References 8 publications

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“…18,19 Several inflammatory mediators like complement, histamine, kinins, prostaglandins and pro-inflammatory cytokines have been suggested to play a role in the mechanism of inflammation. [20][21] Edema, which develops after egg albumin injection, is a biphasic event. The initial phase is attributed to the release of histamine and serotonin and lasting up to 2 h. While the later phase, occurring from 3 to 5 h after the injection of the irritant is induced by bradykinin, protease, prostaglandins and lysosome.…”

mentioning

confidence: 99%

Acute Toxicity, Anti-ulcer and Anti-inflammatory Effects of Methanol Extract of Gladiolus segetum in Rats

Marref¹,

Benkiki²,

Melakhessou³

et al. 2018

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Objectives:To evaluate the in vivo anti-ulcer and anti-inflammatory activities of methanol extract of the aerial parts of Gladiolus segetum. Methods: first methanol extract of Gladiolus segetum was subjected to the acute oral toxicity test according to the OECD, guideline no 423.The anti-ulcer activity of Gladiolus segetum was investigated by ethanol induced gastric ulcer in Wistar rats. Methanol extract was administered by gavage one hour before ethanol to the different groups at a dose corresponding of 100,250 and 500 mg/kg body weight. The control group received normal saline in comparable volume (10ml/kg body weight) by the same route. The anti-inflammatory activity of the tested extract was evaluated in adult wistar rats by the egg albumin induced paw edema method. Results: A significant reduction (p <0.001) was observed in the results of the present study, revealed that methanol extract possessed gastroprotective activity and exerts a topical anti-inflammatory effect in vivo. Conclusion: These results suggest that methanol extract of Gladiolus segetum may represent an important clinical alternative in anti-inflammatory and antiulcer genic therapeutics.

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confidence: 99%

Acute Toxicity, Anti-ulcer and Anti-inflammatory Effects of Methanol Extract of Gladiolus segetum in Rats

Marref¹,

Benkiki²,

Melakhessou³

et al. 2018

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“…The mechanisms of the suppressive action could be direct, by elimination of potentially toxic agents as superoxide and hydrogen peroxide, or indirect, by prevention of the formation of hydroxyl radicals and lipid peroxides. Although several investigators independently demonstrated the effects of scavenging enzymes in different models of experimental inflammation, other data cast some doubt on the general validity of these findings (37,38).…”

Section: Resultsmentioning

confidence: 99%

Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice.

Schalkwijk¹,

Berg²,

Putte³

et al. 1985

J. Clin. Invest.

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Several enzymes and other proteins were made cationic either by coupling to polylysine or by shielding of anionic sites. These cationic proteins, all having an isoelectric point >8.5 exhibited excellent retention in articular structures when injected in mouse knee joints. Autoradiography and histochemistry showed that cationic forms of catalase, superoxide dismutase, and horseradish peroxidase were firmly retained by synovial and cartilaginous tissues. The half-life of these enzymes in the joint is thus significantly extended compared with native enzymes. The native enzymes and their cationic derivatives were tested for antiinflammatory properties in mice, using antigeninduced arthritis and zymosan-induced arthritis. It was found that injection of cationic catalase or peroxidase induced a marked suppression of some parameters of the inflammatory response in both types of arthritis, as measured by ""'technetium pertechnetate uptake and leakage of I251-labeled albumin. Native catalase and peroxidase were less, or not at all effective. Cationic superoxide dismutase or cationic nonenzyme proteins did not suppress inflammation. The observed suppression of two different types of inflammation (an immune and a nonimmune arthritis) by catalase and peroxidase suggests that elimination of peroxides contributes to the suppression of an inflammatory response.We would hypothesize that cationic enzymes offer the possibility for investigating the mechanisms of inflammation and, in addition, might be interesting from a therapeutical point of view.

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“…No significant change was seen in the post treated group. Evidence exists that SOD were found to inhibit the primary phase of the adjuvant arthritis but had no effect on the secondary phase of adjuvant arthritis (26). This shows that when Type II colragen is given after the onset of the disease, it has no role on the activity of superoxide dismutase.…”

Section: Discussionmentioning

confidence: 98%

Effect of type II collagen treatment on the antioxidant status in immune tissues of adjuvant induced arthritic rats

Ganesan

Hariprasad

Chandrasekaran

2003

Indian J Clin Biochem

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Adjuvant induced arthritis (AIA) is a model widely used to study Rheumatoid arthritis (RA). In the present study, lipid peroxides level in spleen and thymus of AIA rats was observed to be significantly high compared to normal rats. A significant decrease in ascorbic acid (ASA), reduced glutathione (GSH), superoxide dismutase activity (SOD) was also observed in spleen and thymus of AIA rats compared to normal rats. There was also a steady increase in the circulating immune complex level (CIC) throughout the experimental period in serum of AIA rats. In the present investigation, it was decided to study the effect of pre and post treatment with TYPE II collagen on the antioxidant status and the circulating immune complex level in AIA rats. The results from the present work indicates that the pretreatment with TYPE II collagen was effective in bringing significant changes on all the parameters studied in AIA rats. The post treatment with TYPE II collagen was effective in bringing significant changes on the CIC immune complex level and GSH content in the thymus tissue of AIA rats. The present work suggests that the pre treatment with TYPE II collagen was more effective in suppressing the disease than the post treatment.

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Effects of catalase, peroxidase, superoxide dismutase and 10 scavengers of oxygen radicals in carrageenin edema and in adjuvant arthritis of rats

Cited by 47 publications

References 8 publications

Acute Toxicity, Anti-ulcer and Anti-inflammatory Effects of Methanol Extract of Gladiolus segetum in Rats

Acute Toxicity, Anti-ulcer and Anti-inflammatory Effects of Methanol Extract of Gladiolus segetum in Rats

Cationization of catalase, peroxidase, and superoxide dismutase. Effect of improved intraarticular retention on experimental arthritis in mice.

Effect of type II collagen treatment on the antioxidant status in immune tissues of adjuvant induced arthritic rats

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