Effect of type II collagen treatment on the antioxidant status in immune tissues of adjuvant induced arthritic rats

Ganesan, Nalini; Hariprasad, Chegu; Chandrasekaran, A. N.

doi:10.1007/bf02867390

Cited by 2 publications

(1 citation statement)

References 28 publications

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“…In groups treated with Vit C and GTE, levels of GSH elevated to reach normal levels. Low levels of GSH in RA had been reported (42). In addition, Kraus and his coworkers found that Zn-deficient rats have lowered GSH concentrations (43).…”

Section: Effect Of Green Tea Extract and Vitamin Cmentioning

confidence: 97%

Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model

Meki

Hamed

Ezam

2009

Indian J Clin Biochem

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Elevated free radical generation in inflamed joints and impaired antioxidant system has been implicated in rheumatoid arthritis (RA). Green tea extracts (GTE) have been shown to reduce inflammation in inflammatory arthritis murine model. This study investigates possible mechanisms by which vitamin C and GTE protect joints in RA rat model. This study included forty adult male rats that were divided into four groups (10 rats each); control group, collagen II induced RA group (CII), CII treated with vitamin C (CII + Vit C) and CII treated with GTE (CII + GTE) in physiology laboratory, Assiut University, Egypt. After 45 days of treatment, plasma levels of lipid peroxides (LPO), nitric oxide (NO), ceruloplasmin (CP), superoxide dismutase (SOD), uric acid (UA) and glutathione (GSH) were detected using colorimetric methods, PGE(2) using ELISA and copper (Cu) and zinc (Zn) using spectrometer. In CII group, levels of LPO, NO, PGE(2), UA, CP, Cu were higher while SOD, GSH, Zn were lower than controls. In groups treated with vitamin C and GTE, levels of SOD, GSH were increased while levels of LPO, NO, PGE(2), Cu, CP were decreased compared with CII group. Levels of UA were decreased and Zn increased in GTE treated group compared with CII group. GTE treated group showed higher Zn and low Cu levels compared with vitamin C treated group. This study suggests proper GTE and vitamin C intake may effectively normalize the impaired oxidant/antioxidant system and delaying complication of RA.

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Section: Effect Of Green Tea Extract and Vitamin Cmentioning

confidence: 97%

Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model

Meki

Hamed

Ezam

2009

Indian J Clin Biochem

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Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i> Infection

El-Banna¹,

El-Aziz²,

El-Mahdy³

et al. 2015

JBM

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There is growing interest in re-evaluation of older antibiotics with the wide spread of pathogen resistance, especially gram negative bacteria, which impair treatment of some infections. In contrast various studies have reported that some antibiotics have efficacy in clearing resistant bacterial infections. On account of that it was interesting to evaluate the efficacy of erythromycin, chloramphenicol and/or tenoxicam in curing and/or relieving wound infection of highly resistant Escherichia coli and investigate the possible mechanisms beyond their antibacterial activity. This was achieved through evaluating highly resistant E. coli strains in vitro using agar dilution and in vivo rat models of E. coli infected wound and acute inflammation by carrageenin, where possible mechanisms were evaluated through measuring immunological mediators and histopathological examination. This study revealed that in vivo, erythromycin alone or in combination with tenoxicam significantly improved the healing of infected skin wounds with E. coli irresspective of resistancy in vitro. In addition to the improvement of immunological mediators involved in inflammatory reaction, oxidative stress and in cytokines expression as response to the bacterial infection in vivo. On the other hand chloramphenicol neither alone nor in combination with tenoxicam, achieved any significant effect. Tenoxicam didn't show antimicrobial activity alone nor in combination with tested antibiotics in vitro, but it has shown synergestic activity in combination with tested antibiotics in vivo. Thus we concluded that immunomodulatory activity of erythromycin through anti-inflammatory and antioxidant effects was the possible mechanisms by which this antibiotic had healed infection with resistant E. coli in vivo, despite its resistancy to this antibiotic in vitro.

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Effect of type II collagen treatment on the antioxidant status in immune tissues of adjuvant induced arthritic rats

Cited by 2 publications

References 28 publications

Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model

Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model

Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i> Infection

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Effect of type II collagen treatment on the antioxidant status in immune tissues of adjuvant induced arthritic rats

Cited by 2 publications

References 28 publications

Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model

Effect of green tea extract and vitamin C on oxidant or antioxidant status of rheumatoid arthritis rat model

Efficacy of Some Antibiotics in Curing Resistant &lt;i&gt;Escherichia coli&lt;/i&gt; Infection

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Efficacy of Some Antibiotics in Curing Resistant <i>Escherichia coli</i> Infection