Effects of carbon tetrachloride on oxidative stress, inflammatory response and hepatocyte apoptosis in common carp (Cyprinus carpio)

Jia, Rui; Cao, Li; Du, Jin; Wang, Jia Hao; Liu, Ying Juan; Jeney, Galina; Xu, Pao; Yin, Guo

doi:10.1016/j.aquatox.2014.02.014

Cited by 80 publications

(39 citation statements)

References 57 publications

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“…The activities of superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) in the gills were measured using commercially available kits (Jiancheng Institute of Biotechnology, Nanjing, China) and expressed as unit per milligram protein (Jia et al, 2014). SOD activity was measured according to the method of Peskin and Winterbourn (2000), using water-soluble tetrazolium salt as a superoxide detector.…”

Section: Determination Of Oxidative Stress Parametersmentioning

confidence: 99%

Effects of nitrite exposure on haematological parameters, oxidative stress and apoptosis in juvenile turbot (Scophthalmus maximus)

Jia¹,

et al. 2015

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Section: Determination Of Oxidative Stress Parametersmentioning

confidence: 99%

Effects of nitrite exposure on haematological parameters, oxidative stress and apoptosis in juvenile turbot (Scophthalmus maximus)

Jia¹,

et al. 2015

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“…In this study, the CYP2E1-like protein was not detected using several antibodies against human and rat epitopes; however the CYP2E1 protein level was successfully determined and responded to carbon tetrachloride treatment in common carp liver (Jia et al, 2014). In future studies, it could be desirable to develop CYP2E1 antibodies against fish CYP2E1.…”

Section: Discussionmentioning

confidence: 49%

Does dexamethasone affect hepatic CYP450 system of fish? Semi-static in-vivo experiment on juvenile rainbow trout

et al. 2015

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“…While structural similarity does not guarantee similar gene expression responses, literature review does suggest that these compounds should share some common mode of action. For example, all four compounds are metabolized by the cytochrome P450 metabolizing enzyme CYP2E1 and/or alcohol dehydrogenase (ADH) causing oxidative stress which (partially) explains their hepatotoxic effects [47][48][49][50][51][52]. An explanation for the scattered clustering in the meta-analysis could lay in the fact that some essential information in the gene expression metaanalysis may get lost since we found that some compounds did cluster similarly to the protein target z-scores and Tanimoto scores when a distinction was made based on, for example, dose and exposure time (results not shown).…”

Section: Results Of Individual Data Analysis Approachesmentioning

confidence: 99%

A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure

Hebels

Rasche

Herwig

et al. 2016

Methods in Molecular Biology

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When evaluating compound similarity, addressing multiple sources of information to reach conclusions about common pharmaceutical and/or toxicological mechanisms of action is a crucial strategy. In this chapter, we describe a systems biology approach that incorporates analyses of hepatotoxicant data for 33 compounds from three different sources: a chemical structure similarity analysis based on the 3D Tanimoto coefficient, a chemical structure-based protein target prediction analysis, and a cross-study/cross-platform meta-analysis of in vitro and in vivo human and rat transcriptomics data derived from public resources (i.e., the diXa data warehouse). Hierarchical clustering of the outcome scores of the separate analyses did not result in a satisfactory grouping of compounds considering their known toxic mechanism as described in literature. However, a combined analysis of multiple data types may hypothetically compensate for missing or unreliable information in any of the single data types. We therefore performed an integrated clustering analysis of all three data sets using the R-based tool iClusterPlus. This indeed improved the grouping results. The compound clusters that were formed by means of iClusterPlus represent groups that show similar gene expression while simultaneously integrating a similarity in structure and protein targets, which corresponds much better with the known mechanism of action of these toxicants. Using an integrative systems biology approach may thus overcome the limitations of the separate analyses when grouping liver toxicants sharing a similar mechanism of toxicity.

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Effects of carbon tetrachloride on oxidative stress, inflammatory response and hepatocyte apoptosis in common carp (Cyprinus carpio)

Cited by 80 publications

References 57 publications

Effects of nitrite exposure on haematological parameters, oxidative stress and apoptosis in juvenile turbot (Scophthalmus maximus)

Effects of nitrite exposure on haematological parameters, oxidative stress and apoptosis in juvenile turbot (Scophthalmus maximus)

Does dexamethasone affect hepatic CYP450 system of fish? Semi-static in-vivo experiment on juvenile rainbow trout

A Systems Biology Approach for Identifying Hepatotoxicant Groups Based on Similarity in Mechanisms of Action and Chemical Structure

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