Effects of nitrite exposure on haematological parameters, oxidative stress and apoptosis in juvenile turbot (Scophthalmus maximus)

Jia, Rui; Han, Cen; Lei, Jilin; Liu, Baoliang; Huang, Bin; Huo, Huanhuan; Yin, Shuting

doi:10.1016/j.aquatox.2015.09.016

Cited by 104 publications

(45 citation statements)

References 88 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several in vivo and in vitro studies have reported nitrite toxicity mediated through oxidative stress [17,18]. This is supported by reports that antioxidants can ameliorate nitrite toxicity [19,20].…”

Section: Introductionmentioning

confidence: 81%

Acute oral dose of sodium nitrite induces redox imbalance, DNA damage, metabolic and histological changes in rat intestine

Ansari¹,

Ali²,

Arif³

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

Industrialization and unchecked use of nitrate/nitrite salts for various purposes has increased human exposure to high levels of sodium nitrite (NaNO2) which can act as a pro-oxidant and pro-carcinogen. Oral exposure makes the gastrointestinal tract particularly susceptible to nitrite toxicity. In this work, the effect of administration of a single acute oral dose of NaNO2 on rat intestine was studied. Animals were randomly divided into four groups and given single doses of 20, 40, 60 and 75 mg NaNO2/kg body weight. Untreated animals served as the control group. An NaNO2 dose-dependent decline in the activities of brush border membrane enzymes, increase in lipid peroxidation, protein oxidation, hydrogen peroxide levels and decreased thiol content was observed in all treated groups. The activities of various metabolic and antioxidant defense enzymes were also altered. NaNO2 induced a dose-dependent increase in DNA damage and DNA-protein crosslinking. Histopathological studies showed marked morphological damage in intestinal cells. The intestinal damage might be due to nitrite-induced oxidative stress, direct action of nitrite anion or chemical modification by reaction intermediates.

show abstract

Section: Introductionmentioning

confidence: 81%

Acute oral dose of sodium nitrite induces redox imbalance, DNA damage, metabolic and histological changes in rat intestine

Ansari¹,

Ali²,

Arif³

et al. 2017

PLoS ONE

View full text Add to dashboard Cite

show abstract

“…Another potential explanation for the positive effects of tryptophan in fish exposed to toxic substances might be mitigation of oxidative stress through its antioxidant property, as described above. This is because the toxic agents used in the commented studies are all known to cause oxidative damage in fish (Rom eo et al 2000;Sanchez et al 2005;Vutukuru et al 2006;Ciji et al 2012Ciji et al , 2015Jia et al 2015;Wei & Yang 2016).…”

Section: Tryptophan Antitoxic Effectsmentioning

confidence: 99%

Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

Hoseini

Pérez‐Jiménez

Costas

et al. 2017

Reviews in Aquaculture

View full text Add to dashboard Cite

Tryptophan is an essential amino acid with a huge functional versatility, in addition to its participation in protein synthesis. Because of the complexity of its metabolism, and the functional relevance of several of its metabolites, it directly or indirectly participates in a wide array of physiological pathways. This amino acid is a precursor for the synthesis of the neurotransmitter/neuromodulator serotonin (5HT), the hormone melatonin and kynurenine and related compounds such as kynurenic acid, quinolinic acid or niacin. Because of this, it has a key role in the regulation of processes ranging from the neuroendocrine to the immune system in vertebrates. In aquaculture, extensive research has been performed to optimize the levels of tryptophan in the commercial diets for many fish species. Providing adequate levels of this amino acid is critically important for fish growth but also for fish welfare, as tryptophan has been shown to modulate fish behaviour, stress responses, and antioxidant and immune systems. Currently, available data suggest a wide variation in tryptophan requirements of different species ranging 0.3–1.3% of dietary protein level, but recent evidence also shows that fish tryptophan requirements can greatly vary depending on the rearing conditions of the fish. We also review here the participation of tryptophan and related metabolites in different physiological functions that are crucial for fish welfare. The review covers the involvement of tryptophan in 5HT‐ and melatonin‐mediated functions, along with its participation in the regulation of the immune system and its role as an antioxidant and antitoxic agent in fish.

show abstract

“…The authors suggested that the response to lower concentrations of nitrate may reflect modulation of physiological processes whereas inhibition of testosterone secretion at high concentrations of nitrate reflected a direct toxicological effect (see Valenti et al 1999). A positive effect of nitrite exposure on plasma cortisol levels was observed in rohu (Labeo rohita Hamilton) where it was accompanied by a negative effect on plasma testosterone and estradiol levels (Ciji et al 2013), and in turbot (Scophthalmus maximus L.; Jia et al 2015). One other study, on salamander larvae (Ambystoma jeffersonianum Green), reported a positive relationship between nitrate concentrations and stress axis function in which higher stress-induced corticosterone levels were observed in animals inhabiting high-nitrate ponds (Chambers et al 2013).…”

Section: Discussionmentioning

confidence: 99%

Modulation of the stress response in wild fish is associated with variation in dissolved nitrate and nitrite

Pottinger

2017

Environmental Pollution

View full text Add to dashboard Cite

Article (refereed) -postprintPottinger, Tom G. 2017. Modulation of the stress response in wild fish is associated with variation in dissolved nitrate and nitrite.Contact CEH NORA team at noraceh@ceh.ac.ukThe NERC and CEH trademarks and logos ('the Trademarks') are registered trademarks of NERC in the UK and other countries, and may not be used without the prior written consent of the Trademark owner. respectively. These data suggest that either (i) inorganic N is a better surrogate than wastewater effluent concentration for an unknown factor or factors affecting stress axis function in fish, or (ii) dissolved inorganic N directly exerts a disruptive influence on the function of the neuroendocrine stress axis in fish, supporting concerns that nitrate is an endocrine-modulating chemical. KeywordsStickleback, stress axis, cortisol, endocrine disruption, nitrate CapsuleEvidence is presented that the function of the neuroendocrine stress axis in three-spined sticklebacks may be modulated by dissolved inorganic N concentrations, supporting concerns that nitrate might act as an endocrine disruptor in aquatic wildlife.3

show abstract

Effects of nitrite exposure on haematological parameters, oxidative stress and apoptosis in juvenile turbot (Scophthalmus maximus)

Cited by 104 publications

References 88 publications

Acute oral dose of sodium nitrite induces redox imbalance, DNA damage, metabolic and histological changes in rat intestine

Acute oral dose of sodium nitrite induces redox imbalance, DNA damage, metabolic and histological changes in rat intestine

Physiological roles of tryptophan in teleosts: current knowledge and perspectives for future studies

Modulation of the stress response in wild fish is associated with variation in dissolved nitrate and nitrite

Contact Info

Product

Resources

About