Effects of carbohydrate availability on lipogenesis in sheep

Ballard, F. J.; Filsell, O H; Jarrett, I. G.

doi:10.1042/bj1260193

Cited by 86 publications

(42 citation statements)

References 21 publications

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“…Increased glucose availability in the diet and intravenous, intra-abomasal or intra-duodenal glucose infusion all result in increases in fatty acid synthesis from glucose and lipogenic enzyme activity in sheep liver and adipose tissue (Ballard et al 1972 Lactate has been reported to be a significant lipogenic precursor for fatty acid synthesis in both sheep and cattle adipose tissue (Prior, 1978;Whitehurst et al 1978). The negligible incorporation of radioactivity from [ ~-'"Cllactate into fatty acids suggests that the route of metabolism is via pyruvate dehydrogenase (Vernon, 1980a) and this is supported by the results of which show that lactate is converted to fatty acids via citrate; the latter authors suggest that the activities of ATP-citrate lyase and malate dehydrogenase (oxaloacetatedecarboxylating) (NADP+) are not rate-limiting in the conversion of lactate to fatty acids.…”

Section: -10%mentioning

confidence: 99%

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Fatty acid synthesis in liver and adipose tissue

Pearce¹

1983

Proc. Nutr. Soc.

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Section: -10%mentioning

confidence: 99%

“…The lack of utilization of glucose in fatty acid biosynthesis is reflected in the very low specific activities of ATP-citrate lyase, malate dehydrogenase (oxaloacetate-decarboxylating) (NADP+) and pyruvate dehydrogenase in ruminant tissues (Ballard et al 1972; Robertson et al 1980). …”

Section: -10%mentioning

confidence: 99%

Fatty acid synthesis in liver and adipose tissue

Pearce¹

1983

Proc. Nutr. Soc.

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“…Le métabolisme des lipides dans le foie de ruminant a été décrit par Rémésy et al (1984, 1986 Ballard, 1967Ballard et al, 1969Ballard et al, , 1972Hood et a/., 1972 ; Ingle et al, 1972a, b ;Vézinhet, 1976 ;Liepa et al, 1978 ;Prior, 1978 ;Smith et Crouse, 1984 …”

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Revue bibliographique : Variations quantitatives et métabolisme des lipides dans les tissus adipeux et le foie au cours du cycle gestation-lactation 2e partie : chez la brebis et la vache

Chilliard¹

1987

Reprod. Nutr. Dévelop.

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(cf. I.N.R.A., 1978) Par rapport à la ratte, qui a fait l'objet de la première partie de cette revue bibliographique (Chilliard, 1986), les ruminants présentent des particularités digestives qui conditionnent largement, par la nature des nutriments absorbés, l'orientation de leur métabolisme. En effet, les aliments qu'ils ingèrent, riches en parois végétales, séjournent pendant 15 à 48 h dans le rumen-réseau (dont le contenu est de 60 à 100 I chez le bovin adulte), où ils subissent une dégradation plus ou moins complète sous l'action des enzymes sécrétées par les micro-organismes qui y pullulent (10 10 par ml).Les (Basset, 1975). Le métabolisme des lipides dans le foie de ruminant a été décrit par Rémésy et al. (1984, 1986 Ballard, 1967Ballard et al., 1969Ballard et al., , 1972Hood et a/., 1972 ; Ingle et al., 1972a, b ;Vézinhet, 1976 ;Liepa et al., 1978 ;Prior, 1978 ;Smith et Crouse, 1984

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“…These known effects are coherent with the increase in plasma glucose and insulin concentrations observed in the present study in steers fed maize silage compared with cut grass and could result in higher lipogenic enzyme and LPL activities in AT. Indeed, although glucose is of minor importance as a carbon source for FA synthesis, the oxidation of glucose via the pentose phosphate pathway is an important source of reduced NADP, whereas its oxidation via glycolysis contributes to 3-glycerol phosphate for FA esterification in ruminant AT (Ballard et al, 1972;Janes et al, 1985). It could thus be hypothesized that lipogenic potential (as measured in vitro) was increased by glucose and insulin in the maize silage group and/or decreased by PUFA in the grass-fed groups, but that this potential was not expressed in vivo because of the management of animals at similar growth rates.…”

Section: Discussionmentioning

confidence: 99%

Influence of the diet and grazing on adipose tissue lipogenic activities and plasma leptin in steers

Faulconnier

Ortigues-Marty

Delavaud

et al. 2007

Animal

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The objectives of the two experiments were to determine the respective effects and interactions of diet type (grass v. maize diets) and physical activity (grazing v. zero grazing) on lipogenic enzyme activities and adipose cell size in subcutaneous, perirenal and intermuscular adipose tissues and on plasma metabolites and hormones in Charolais steers. After weaning, the steers were assigned to two (Experiment 1, n 5 24) or three (Experiment 2, n 5 24) groups, with steers in Experiment 1 grazed grass or indoors maize-silage-fed and steers in Experiment 2 grazed grass, indoors cut grass-or indoors maize-silage-fed. Both experiments lasted for 23 months. All grass-fed animals were fed grass silage during the two winter seasons. During the two summer seasons, steers fed on grass were rotationally grazed on a perennial rye-grass pasture while steers fed on cut grass were fed indoors on freshly cut grass alone. Steers fed on maize silage were fed maize silage indoors during the entire experiment. All animals were reared for similar body weight and growth rates and slaughtered at the same age (31 to 32 months). Activities of lipogenic enzymes were significantly lower in the three adipose tissue sites of steers fed cut grass compared with maize silage, although there were less-marked effects in intermuscular adipose tissue. Plasma insulin and glucose concentrations were also lower in steers fed cut grass whereas plasma leptin concentration was similar. As body fat content was not affected by nutritional treatment, it is suggested that the decrease in potential lipogenic activity was associated with the nature of the diet and not to differences in available net energy. In other respects, grazed grass compared with eating cut grass did not affect lipogenic enzyme activities but decreased plasma leptin concentrations in the older steers and increased plasma non-esterified fatty acids and glucose concentrations without affecting adipose tissue weight and adipose cell size.

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Effects of carbohydrate availability on lipogenesis in sheep

Cited by 86 publications

References 21 publications

Fatty acid synthesis in liver and adipose tissue

Fatty acid synthesis in liver and adipose tissue

Revue bibliographique : Variations quantitatives et métabolisme des lipides dans les tissus adipeux et le foie au cours du cycle gestation-lactation 2e partie : chez la brebis et la vache

Influence of the diet and grazing on adipose tissue lipogenic activities and plasma leptin in steers

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