Effects of carbendazim and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer cells

Atalay, Pinar Buket; Kuku, Gamze; Tuna, Bilge Güvenç

doi:10.1007/s11626-018-0312-0

Cited by 33 publications

(24 citation statements)

References 30 publications

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“…In this context, although several factors such as insulin, IGF‐I, leptin, adiponectin, estrogen, cytokines, adropin, and sirtuins have been suggested to be responsible for the anticancer effects of CR, the exact mechanism(s) remains to be elucidated . On the other hand, roles for oxidative stress have also been reported in numerous physiological and pathophysiological conditions . In addition, several studies have reported protective effects of CR in oxidative stress‐related diseases including Alzheimer's disease, cardiovascular disease, diabetes, and also aging.…”

Section: Discussionmentioning

confidence: 99%

Effects of long‐term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model

et al. 2019

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Section: Discussionmentioning

confidence: 99%

Effects of long‐term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model

et al. 2019

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“…Zeaxanthin and violaxanthin were capable of enhancing the antiproliferative effect of epirubicin on MCF-7 cells resistant to anthracycline [151] (MCF10A) [148] (Figure 4). Co-treatment of astaxanthin with the Phase I anticancer drug carbendazim showed a synergistic effect on the MCF-7 cell lines [149]. In combination with hyperthermia, crocin successfully inhibited the growth of the MDA-MB-468 TNBC cell line, whereas MCF-10A normal cells were not affected [150].…”

Section: In Vitro and In Vivo Studiesmentioning

confidence: 97%

Halophilic Carotenoids and Breast Cancer: From Salt Marshes to Biomedicine

Giani

Montoyo-Pujol²,

Peiró³

et al. 2021

Marine Drugs

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Breast cancer is the leading cause of death among women worldwide. Over the years, oxidative stress has been linked to the onset and progression of cancer. In addition to the classical histological classification, breast carcinomas are classified into phenotypes according to hormone receptors (estrogen receptor—RE—/progesterone receptor—PR) and growth factor receptor (human epidermal growth factor receptor—HER2) expression. Luminal tumors (ER/PR-positive/HER2-negative) are present in older patients with a better outcome. However, patients with HER2-positive or triple-negative breast cancer (TNBC) (ER/PR/HER2-negative) subtypes still represent highly aggressive behavior, metastasis, poor prognosis, and drug resistance. Therefore, new alternative therapies have become an urgent clinical need. In recent years, anticancer agents based on natural products have been receiving huge interest. In particular, carotenoids are natural compounds present in fruits and vegetables, but algae, bacteria, and archaea also produce them. The antioxidant properties of carotenoids have been studied during the last years due to their potential in preventing and treating multiple diseases, including cancer. Although the effect of carotenoids on breast cancer during in vitro and in vivo studies is promising, clinical trials are still inconclusive. The haloarchaeal carotenoid bacterioruberin holds great promise to the future of biomedicine due to its particular structure, and antioxidant activity. However, much work remains to be performed to draw firm conclusions. This review summarizes the current knowledge on pre-clinical and clinical analysis on the use of carotenoids as chemopreventive and chemotherapeutic agents in breast cancer, highlighting the most recent results regarding the use of bacterioruberin from haloarchaea.

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“…It also blocks angiogenesis and metastasis to distant tissues (Faraone et al, 2020). On combinatorial treatment with carbendazim, AXT potentiates the anti-proliferative effect of this drug by arresting MCF-7 cells at the G2/M phase (Atalay et al, 2019).…”

Section: Astaxanthinmentioning

confidence: 99%

Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

Ferdous

Yusof

2021

Front. Pharmacol.

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Though cancer therapeutics can successfully eradicate cancerous cells, the effectiveness of these medications is mostly restricted to several deleterious side effects. Therefore, to alleviate these side effects, antioxidant supplementation is often warranted, reducing reactive species levels and mitigating persistent oxidative damage. Thus, it can impede the growth of cancer cells while protecting the normal cells simultaneously. Moreover, antioxidant supplementation alone or in combination with chemotherapeutics hinders further tumor development, prevents chemoresistance by improving the response to chemotherapy drugs, and enhances cancer patients’ quality of life by alleviating side effects. Preclinical and clinical studies have been revealed the efficacy of using phytochemical and dietary antioxidants from different sources in treating chemo and radiation therapy-induced toxicities and enhancing treatment effectiveness. In this context, algae, both micro and macro, can be considered as alternative natural sources of antioxidants. Algae possess antioxidants from diverse groups, which can be exploited in the pharmaceutical industry. Despite having nutritional benefits, investigation and utilization of algal antioxidants are still in their infancy. This review article summarizes the prospective anticancer effect of twenty-three antioxidants from microalgae and their potential mechanism of action in cancer cells, as well as usage in cancer therapy. In addition, antioxidants from seaweeds, especially from edible species, are outlined, as well.

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Effects of carbendazim and astaxanthin co-treatment on the proliferation of MCF-7 breast cancer cells

Cited by 33 publications

References 30 publications

Effects of long‐term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model

Effects of long‐term intermittent versus chronic calorie restriction on oxidative stress in a mouse cancer model

Halophilic Carotenoids and Breast Cancer: From Salt Marshes to Biomedicine

Medicinal Prospects of Antioxidants From Algal Sources in Cancer Therapy

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