Effects of capsaicin analogs on adrenal catecholamine secretion in rats

Capsiate, a Nonpungent Capsaicin Analog, Increases Endurance Swimming Capacity of Mice by Stimulation of Vanilloid Receptors

“…Watanabe et al have reported that the long-chain nonpungent capsaicin analogs, whose side alkyl chain is C 10 to C 20 , stimulated adrenaline release as effectively as hot capsaicin. 2) Indeed, the chemically synthesized C 18 long-chain capsaicin analog, which did not show any pungency, increased the fat utilization and endurance swimming capacity of mice. 3) Unfortunately, these nonpungent long-chain capsaicin analogs are minor components in natural hot pepper fruit and are particularly difficult to isolate from hot capsaicin.…”

Enzymatic Synthesis of a Capsinoid by the Acylation of Vanillyl Alcohol with Fatty Acid Derivatives Catalyzed by Lipases

“…6,7) Vanillyl ( Z )-9-octadecenamide (C18:1), named olvanil, possesses capsaicin-like biological and physiological properties without any noxious stimuli. 8,9) We were therefore interested in capsiate analogues with various lengths of the acyl moiety, and attempted their lipase-catalyzed synthesis under the optimum conditions just described.…”

“…4) Great interest in non-pungent analogues of capsaicin and its related substances has arisen in respect of their various biological and physiological activities without noxious stimuli. [5][6][7][8][9][10][11] Capsinoids can be chemically synthesized by the condensation of vanillyl alcohol and a fatty acid chloride. 11) However, there are some drawbacks to this method: for example, the toxicity of the condensing and catalytic agents, the formation of byproducts, and such complicated processes as the protection and release of the aromatic hydroxyl group.…”

Effect of a Dietary Supplement Containing Raspberry Ketone on Cytochrome P450 3A Activity

“…The skeletal structure of raspberry ketone is partially similar to capsaicin, the principal component of capsicum fruits (Figure 1), which reportedly increases the secretion of catecholamines [7] and energy expenditure [8] while suppressing body fat accumulation [9]. Capsaicin is also a well-known inhibitor…”