Capsiate, a Nonpungent Capsaicin Analog, Increases Endurance Swimming Capacity of Mice by Stimulation of Vanilloid Receptors

Haramizu, Satoshi; Mizunoya, Wataru; Masuda, Yasuhisa; Ohnuki, Koichiro; Watanabe, Tatsuo; Yazawa, Susumu; Fushiki, Tohru

doi:10.1271/bbb.70.774

Cited by 37 publications

(25 citation statements)

References 28 publications

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“…Both single and chronic CSN supplementation protocols have been reported to increase energy expenditure (11,15,31,39,40,50). This CSNs-dependent increase in energy expenditure may be mediated by activation of the SNS.…”

Section: Discussionmentioning

confidence: 99%

A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice

Ohyama

Nogusa

Suzuki

et al. 2015

American Journal of Physiology-Endocrinology and Metabolism

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Exercise effectively prevents the development of obesity and obesity-related diseases such as type 2 diabetes. Capsinoids (CSNs) are capsaicin analogs found in a nonpungent pepper that increase whole body energy expenditure. Although both exercise and CSNs have antiobesity functions, the effectiveness of exercise with CSN supplementation has not yet been investigated. Here, we examined whether the beneficial effects of exercise could be further enhanced by CSN supplementation in mice. Mice were randomly assigned to four groups: 1) high-fat diet (HFD, Control), 2) HFD containing 0.3% CSNs, 3) HFD with voluntary running wheel exercise (Exercise), and 4) HFD containing 0.3% CSNs with voluntary running wheel exercise (Exercise ϩ CSN). After 8 wk of ingestion, blood and tissues were collected and analyzed. Although CSNs significantly suppressed body weight gain under the HFD, CSN supplementation with exercise additively decreased body weight gain and fat accumulation and increased whole body energy expenditure compared with exercise alone. Exercise together with CSN supplementation robustly improved metabolic profiles, including the plasma cholesterol level. Furthermore, this combination significantly prevented diet-induced liver steatosis and decreased the size of adipocyte cells in white adipose tissue. Exercise and CSNs significantly increased cAMP levels and PKA activity in brown adipose tissue (BAT), indicating an increase of lipolysis. Moreover, they significantly activated both the oxidative phosphorylation gene program and fatty acid oxidation in skeletal muscle. These results indicate that CSNs efficiently promote the antiobesity effect of exercise, in part by increasing energy expenditure via the activation of fat oxidation in skeletal muscle and lipolysis in BAT.exercise; capsinoids; obesity; energy expenditure; fat oxidation OBESITY IS RAPIDLY BECOMING a major global health problem (4) and is a major risk factor for several common diseases, including type 2 diabetes, cardiovascular diseases, and cancer (32). Obesity develops when energy intake chronically exceeds total energy expenditure (51). Conventional antiobesity strategies have focused on repressing energy intake by suppressing appetite or inhibiting intestinal fat absorption; however, increasing energy expenditure by activating the metabolic function of skeletal muscle or brown fat could serve as an alternative and effective antiobesity intervention, thereby avoiding the potential adverse effects associated with conventional antiobesity therapies such as depression, oily bowel movements, and steatorrhea.Exercise is one of the most efficient ways to prevent obesity and type 2 diabetes through an increase in energy expenditure (25, 27, 52). However, people in the developed world are becoming less physically active as a result of lifestyle changes and the nature of their work. Moreover, constraints such as lack of time, limited access. and injuries frequently become barriers to exercise (48). For example, a recent epidemiological study estimated that ...

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Section: Discussionmentioning

confidence: 99%

A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice

Ohyama

Nogusa

Suzuki

et al. 2015

American Journal of Physiology-Endocrinology and Metabolism

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“…The increasing trend of A single oral administration of 'capsiate' to mice has been shown to increase the catecholamine, FFA and blood glucose levels concomitantly with a decrease in TG level, 15) and enhanced fat oxidation during running exercise was augmented. 31) These results suggest that an intake of capsinoids would influence fat metabolism such as lipolysis in fat tissues via the sympathetic nervous system (SNS). Cumulative studies about the long-term effect of capsinoids on fat metabolism are elucidating that enhanced metabolism may not be solely attributable to the elevation of UCP expression.…”

Section: Discussionmentioning

confidence: 99%

Enhanced Energy Expenditure and Fat Oxidation in Humans with High BMI Scores by the Ingestion of Novel and Non-Pungent Capsaicin Analogues (Capsinoids)

Inoue

Matsunaga

Satoh

et al. 2007

Bioscience, Biotechnology, and Biochemistry

123

107

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“…The repeated administration of capsiate for two weeks to mice increased oxygen consumption, this increase being greater during periods of darkness, when locomotion and food behavior were increased, than during periods of light. 11) Moreover, our laboratory has revealed that the increase in fat oxidation was greater in mice that had been forced to run on a treadmill after capsiate administration than in mice that had rested after capsiate administration, 28) suggesting the possibility of generating a synergistic effect by combining capsiate intake and exercise. Thus, in the present study, the energy expenditure might also have been increased by CH-19 Sweet intake during daylight when the subject's activity increased.…”

Section: Discussionmentioning

confidence: 99%

Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, in Decreasing the Body Weight and Suppressing Body Fat Accumulation by Sympathetic Nerve Activation in Humans

Kawabata

Inoue

Yazawa

et al. 2006

Bioscience, Biotechnology, and Biochemistry

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101

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Capsiate, a Nonpungent Capsaicin Analog, Increases Endurance Swimming Capacity of Mice by Stimulation of Vanilloid Receptors

Cited by 37 publications

References 28 publications

A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice

A combination of exercise and capsinoid supplementation additively suppresses diet-induced obesity by increasing energy expenditure in mice

Enhanced Energy Expenditure and Fat Oxidation in Humans with High BMI Scores by the Ingestion of Novel and Non-Pungent Capsaicin Analogues (Capsinoids)

Effects of CH-19 Sweet, a Non-Pungent Cultivar of Red Pepper, in Decreasing the Body Weight and Suppressing Body Fat Accumulation by Sympathetic Nerve Activation in Humans

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