Effects of Campomanesia xanthocarpa on inflammatory processes, oxidative stress, endothelial dysfunction and lipid biomarkers in hypercholesterolemic individuals

Viecili, Paulo Ricardo Nazário; Borges, Diego Olschowsky; Kirsten, Karina; Malheiros, Jênifer; Viecili, Eduardo; Melo, Rodolfo Dahlem; Trevisan, Gabriela; Silva, Mariane Arnoldi da; Bochi, Guilherme Vargas; Moresco, Rafael Noal; Klafke, Jonatas Zeni

doi:10.1016/j.atherosclerosis.2014.02.010

Cited by 51 publications

(44 citation statements)

References 58 publications

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“…(Myrtaceae) on inflammatory processes, oxidative stress, endothelial dysfunction, and lipid biomarkers in hypercholesterolemic individuals. According to results, the treatment reduced the blood total cholesterol (TC) and low-density lipoprotein (LDL-C) levels, reduced the oxidative stress in hypercholesterolemic individuals, and improved the levels of nitric oxide (NOx) [8]. In this work, the authors state that their results are in accordance with a previous preclinical study conducted in mice, which showed that this plant was effective in preventing gastric ulcerations and did not produce toxic symptoms [9].…”

Section: Introductionsupporting

confidence: 81%

Investigation of Campomanesia Components: A Fruit of Brazilian Cerrado

Lima¹,

Arakaki²,

SaldanhaTschinkel³

et al. 2017

Active Ingredients From Aromatic and Medicinal Plants

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A survey of chemical composition of the fruit of Campomanesia adamantium used by rural and urban inhabitants of the cities of the Campo Grande, Mato Grosso do Sul State, Brazil, was carried out by inductively coupled plasma-optical emission spectroscopy (ICP-OES) aiming at the detection of minerals. Fifteen minerals were detected in the peel, pulp, and seeds of plant. The concentrations of elements K, Ca, Na, and P are found to be present at the major level in peel, pulp, and seeds of fruit. The zinc concentration is very low compared to other detected elements. The levels of some chemical elements in the fruit do not exceed the limits established by international legislation. Animal studies should be performed. The knowledge of the chemical elements in plants has economic interest, and involves global health problem.

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Section: Introductionsupporting

confidence: 81%

Investigation of Campomanesia Components: A Fruit of Brazilian Cerrado

Lima¹,

Arakaki²,

SaldanhaTschinkel³

et al. 2017

Active Ingredients From Aromatic and Medicinal Plants

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“…The anti-inflammatory activity has been demonstrated in the treatment of hypercholesterolemic individuals with infusions of C. xanthocarpa leaves [11].…”

Section: Discussionmentioning

confidence: 99%

“…In addition to its effect on cholesterol levels, this plant showed potential anti-inflammatory because reduced oxidative stress in hypercholesterolemic patients improving the levels of NOx [11]. Antiplatelet, antithrombotic, and fibrinolytic activities [12] and antioxidant [13], antidiabetic [14], antiulcer activities [15] of C. xanthocarpa leaves were scientifically demonstrated in the literature.…”

Section: Introductionmentioning

confidence: 97%

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

et al. 2016

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Campomanesia xanthocarpa (Myrtaceae) is used in Brazilian traditional medicine against fever, diabetes, hypercholesteremic, obesity, and urinary diseases. In the present study, the compounds 2',6'-dihydroxy-3'-methyl-4'-metoxychalcone and 2',4'-dihydroxy-3',5'-dimethyl-6'-methoxychalcone were identified for the first time in leaves of the C. xanthocarpa. These compounds and the hydroethanolic extract (HECX) significantly inhibited paw edema and reduced both leukocyte migration and the leakage of protein into the pleural cavity. No toxicity was detected by HECX in an acute toxicity test.

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“…As aplicações testadas para bracatinga incluem ação antiviral contra a febre amarela (Ono et al, 2003) (Pereira et al, 2012), já foi descrita para redução dos níveis de colesterol no sangue (Klafke et al, 2010;Viecili et al, 2014). Os efeitos de extratos da guavirova foram investigados em ratos alimentados com dieta hipercalórica, sendo constatada redução significativa no ganho de peso, em comparação ao grupo controle (Biavatti et al, 2004).…”

Section: Resultsunclassified

Potencial Terapêutico de Espécies Arbóreas em Fragmentos de Floresta Ombrófila Mista

et al. 2016

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RESUMOObjetivou-se levantar o potencial terapêutico de espécies arbóreas presentes em remanescentes de Floresta Ombrófila Mista (FOM) localizados no Planalto Sul Catarinense, destacando as que possuem ações terapêuticas atestadas em ensaios científicos, assim como, aquelas com potencial medicinal segundo registros etnobotânicos. Para amostrar a composição florística arbórea foi empregado o método de quadrantes, registrando-se os indivíduos mais próximos do ponto central, que apresentassem DAP ≥ 5 cm. A amostragem foi realizada em Áreas de Preservação Permanente (APP's) e/ou Reserva Legal, com o auxílio de 20 transecções contendo 20 pontos quadrantes cada, totalizando 2,61 hectares. Dentre as 97 espécies registradas e identificadas no levantamento, 16 possuem ação medicinal descrita e atestada em literatura e 12 espécies são descritas como potenciais de acordo com conceitos etnobotânicos. O presente estudo mostrou que pequenos remanescentes florestais podem contribuir para a manutenção de espécies da FOM e basear futuros estudos sobre plantas medicinais ou com outros potenciais bioativos.Palavras-chave: floresta com araucária, conservação florestal, etnobotânica. Therapeutic Potential of Tree Species in Araucaria Forest Fragments ABSTRACTThis study aimed to evaluate the medicinal potential of tree species in Araucaria Forest (FOM) remnants in Santa Catarina Plateau, highlighting those with therapeutic actions attested in scientific trials, as well as those with medicinal potential according to ethnobotanical records. The floristic composition was sampled through the point-centered quarter method, registering the individuals with DBH ≥ 5 cm closest to the center point. Sampling was conducted in Permanent Preservation Areas (APP's) and/or Legal Reserve, with the help of 20 transects with 20 points quadrants each, totaling 2.61 hectares. Among the species recorded and identified, 16 of them, classified into 13 plant families, have medicinal potential described and attested in literature and 12 species within 10 families, are suggested as potential, according to ethnobotanical concepts. The present study showed that these sites may contribute to the maintenance of species of FOM and to base future studies on medicinal plants and/or other bioactive potential.

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Effects of Campomanesia xanthocarpa on inflammatory processes, oxidative stress, endothelial dysfunction and lipid biomarkers in hypercholesterolemic individuals

Cited by 51 publications

References 58 publications

Investigation of Campomanesia Components: A Fruit of Brazilian Cerrado

Investigation of Campomanesia Components: A Fruit of Brazilian Cerrado

Anti-inflammatory Evaluation and Toxicological Analysis of Campomanesia xanthocarpa Berg

Potencial Terapêutico de Espécies Arbóreas em Fragmentos de Floresta Ombrófila Mista

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