Effects of Calcium Antagonism and Beta-Blockade on Haemodynamic Responses to Stress

McInnes, Gordon T.; Findlay, Ian; Glusman, Murray; Dargie, H. J.

doi:10.1159/000184570

Cited by 5 publications

(2 citation statements)

References 6 publications

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“…To our knowledge, this is the first study to investigate the effects of a selective b1-adrenoceptor blocker on BP responses to dynamic resistance exercise. Previous studies have only evaluated the effects of atenolol on isometric resistance exercise [28][29][30][31][32][33][34] or the interaction between atenolol and atropine blockades on BP responses to dynamic resistance exercise [42]. In the present study, using only b-adrenoceptor blockade, we demonstrated that atenolol alone was able not only to decrease the absolute value of systolic BP but also to mitigate its increase during dynamic resistance exercise.…”

Section: Figuresupporting

confidence: 50%

“…The effects of atenolol during aerobic exercise have been extensively studied, and it has been shown that β‐adrenoceptor blockade is able to reduce HR and BP maximum values, as well as their increase during aerobic activity [27]. Atenolol effects were also investigated during isometric resistance exercise, and it was shown that β‐adrenoceptor blockade decreases maximum BP values but does not affect the increase in BP [28–34]. This absence of effect is probably because an increase in systemic vascular resistance is the main mechanism for BP increase during isometric exercise [18, 35].…”

Section: Introductionmentioning

confidence: 99%

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Atenolol blunts blood pressure increase during dynamic resistance exercise in hypertensives

Gomides¹,

Costa²,

Souza³

et al. 2010

Brit J Clinical Pharma

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WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT• Dynamic resistance exercise promotes a sizeable increase in blood pressure during its execution in non medicated hypertensives. WHAT THIS STUDY ADDS• Atenolol not only decreases blood pressure level but also mitigates the increase of blood pressure during dynamic resistance exercise in hypertensive patients. An increase in blood pressure during resistance exercise might be at least in part attributed to an increase in cardiac output. AIMSThis study was conducted to determine whether atenolol was able to decrease BP level and mitigate BP increase during dynamic resistance exercise performed at three different intensities in hypertensives. METHODSTen essential hypertensives (systolic/diastolic BP between 140/90 and 160/105 mmHg) were blindly studied after 6 weeks of placebo and atenolol. In each phase, volunteers executed, in a random order, three protocols of knee-extension exercises to fatigue: (i) one set at 100% of 1 RM; (ii) three sets at 80% of 1 RM; and (iii) three sets at 40% of 1 RM. Intra-arterial radial blood pressure was measured throughout the protocols. RESULTSAtenolol decreased systolic BP maximum values achieved during the three exercise protocols (100% = 186 Ϯ 4 vs. 215 Ϯ 7, 80% = 224 Ϯ 7 vs. 247 Ϯ 9 and 40% = 223 Ϯ 7 vs. 252 Ϯ 16 mmHg, P < 0.05). Atenolol also mitigated an increase in systolic BP in the first set of exercises (100% = +38 Ϯ 5 vs. +54 Ϯ 9; 80% = +68 Ϯ 11 vs. +84 Ϯ 13 and 40% = +69 Ϯ 7 vs. +84 Ϯ 14, mmHg, P < 0.05). Atenolol decreased diastolic BP values and mitigated its increase during exercise performed at 100% of 1 RM (126 Ϯ 6 vs. 145 Ϯ 6 and +41 Ϯ 6 vs. +52 Ϯ 6, mmHg, P < 0.05), but not at the other exercise intensities. CONCLUSIONSAtenolol was effective in both reducing systolic BP maximum values and mitigating BP increase during resistance exercise performed at different intensities in hypertensive subjects.

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