Disparate cardiovascular response to stress tests during isradipine and fosinopril therapy

Amlodipine reduces blood pressure during dynamic resistance exercise in hypertensive patients

“…To the best of our knowledge, this is the first study to describe the effect of a calcium channel antagonist on BP behavior during a dynamic resistance exercise in hypertensive patients. Previous studies have investigated the effect of this class of medication on isometric (Grossman et al., ; Malhotra et al., ), but not dynamic effort, and have reported a reduction in the absolute maximal BP values, but not in BP increase during exercise. In the present study, similar to the results of the isometric studies (Grossman et al., ; Malhotra et al., ), amlodipine reduced the absolute systolic and diastolic BP levels achieved during the exercise protocol regardless of exercise intensity, showing that the hypotensive effect of amlodipine observed at rest was maintained during the dynamic resistance effort.…”

“…Previous studies have investigated the effect of this class of medication on isometric (Grossman et al., ; Malhotra et al., ), but not dynamic effort, and have reported a reduction in the absolute maximal BP values, but not in BP increase during exercise. In the present study, similar to the results of the isometric studies (Grossman et al., ; Malhotra et al., ), amlodipine reduced the absolute systolic and diastolic BP levels achieved during the exercise protocol regardless of exercise intensity, showing that the hypotensive effect of amlodipine observed at rest was maintained during the dynamic resistance effort. However, amlodipine did not affect systolic BP rise during exercise, but abolished diastolic BP increase at low‐intensity exercise, showing that this drug was not able to mitigate or blunt the exercise‐induced systolic hypertensive stimulus, but was able to abolish the low‐intensity exercise‐induced diastolic hypertensive effect over the exercise sets.…”

Exercise testing in hypertensive patients taking different angiotensin-converting enzyme inhibitors

“…In accordance with this hypothesis, Paran et al 13 showed that atenolol inhibited blood pressure response to mental stress, in contrast with enalapril, which was not effective in controlling blood pressure alterations due to mental stress. Similarly, Grossman et al 14 did not report changes in blood pressure response to mental stress in hypertensive patients treated with fosinopril, an angiotensin-converting enzyme inhibitor.…”

Response of blood pressure to maximum exercise in hypertensive patients under different therapeutic programs

“…In our study, no significant difference occurred in blood pressure control during exercise between the group using calcium antagonists and the group using diuretics. The calcium antagonists reduce blood pressure through direct vasodilative action on the smooth vascular muscles, with a reduction in peripheral vascular resistance as a consequence 13,14 . However, they constitute a heterogeneous group of drugs, because phenylalkilamines have a negative effect on chronotropism and inotropism, whereas dihydropyridines do not significantly alter cardiac output 15 .…”