Effects of caffeine on the structure and conformation of DNA: A force spectroscopy study

Moura, Tiago; Oliveira, L. C. de; Rocha, M. S.

doi:10.1016/j.ijbiomac.2019.02.125

Cited by 12 publications

(21 citation statements)

References 42 publications

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“…In fact, the results obtained for the equilibrium binding constant and Hill exponent are within the typical range found for many ligands that exhibit such type of interaction, which usually bind strongly to DNA and exhibit positive cooperativity. In addition, the fact that the contour length remains constant at such a low concentration range strongly supports such a conclusion. ,, …”

mentioning

confidence: 65%

Hydroxychloroquine Exhibits a Strong Complex Interaction with DNA: Unraveling the Mechanism of Action

Bazoni

Moura

Rocha

2020

J. Phys. Chem. Lett.

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mentioning

confidence: 65%

Hydroxychloroquine Exhibits a Strong Complex Interaction with DNA: Unraveling the Mechanism of Action

Bazoni

Moura

Rocha

2020

J. Phys. Chem. Lett.

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“…Caffeine is able to induce E. coli phage φX174 in mitomycin treated E. coli cells [ 108 ]. Since caffeine is known to distort DNA and cause mutations [ 152 ], its activity is supposedly similar to caffeic acid in terms of inducing a stress signal that starts the lytic process.…”

Section: Effect Of Dietary Compounds On Phagesmentioning

confidence: 99%

Dietary Modulation of Bacteriophages as an Additional Player in Inflammation and Cancer

Marongiu

Burkard

Venturelli

et al. 2021

Cancers

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Natural compounds such as essential oils and tea have been used successfully in naturopathy and folk medicine for hundreds of years. Current research is unveiling the molecular role of their antibacterial, anti-inflammatory, and anticancer properties. Nevertheless, the effect of these compounds on bacteriophages is still poorly understood. The application of bacteriophages against bacteria has gained a particular interest in recent years due to, e.g., the constant rise of antimicrobial resistance to antibiotics, or an increasing awareness of different types of microbiota and their potential contribution to gastrointestinal diseases, including inflammatory and malignant conditions. Thus, a better knowledge of how dietary products can affect bacteriophages and, in turn, the whole gut microbiome can help maintain healthy homeostasis, reducing the risk of developing diseases such as diverse types of gastroenteritis, inflammatory bowel disease, or even cancer. The present review summarizes the effect of dietary compounds on the physiology of bacteriophages. In a majority of works, the substance class of polyphenols showed a particular activity against bacteriophages, and the primary mechanism of action involved structural damage of the capsid, inhibiting bacteriophage activity and infectivity. Some further dietary compounds such as caffeine, salt or oregano have been shown to induce or suppress prophages, whereas others, such as the natural sweeter stevia, promoted species-specific phage responses. A better understanding of how dietary compounds could selectively, and specifically, modulate the activity of individual phages opens the possibility to reorganize the microbial network as an additional strategy to support in the combat, or in prevention, of gastrointestinal diseases, including inflammation and cancer.

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“…Its interaction with DNA [29], dyes [39], anticancer and antitumor drugs [40,42], enzymes [41], co-factor NAD + [43], etc., have been studied spectrophotometrically. The thermodynamic evaluation of interactions of caffeine with some of these ligands in aqueous solution also recommends hetero association capacity of caffeine and indicates its therapeutic advantages too [39,40].…”

Section: Comparative Analysis For the Interaction Of Caffeine With Ot...mentioning

confidence: 99%

“…It has been observed that in the brain cells, caffeine improves the motor neural integrity of dissociated wobbler cells via interacting with enzyme and co-factors NAD + and NADH [41][42][43]. Caffeine can protect DNA by forming π -π molecular complex with DNA intercalating agents, decreasing the concentration of free intercalating agents, which is reflected in diminished interaction between intercalants and DNA [29,45,46,48,49,57]. Spectroscopic results also specified the general binding constants of caffeine-DNA binding, which confirms weak ligand-DNA interactions.…”

Section: Comparative Analysis For the Interaction Of Caffeine With Ot...mentioning

confidence: 99%

“…Nevertheless, no information exists on the harmful interactions of caffeine with individual DNA at the molecular level. On the contrary, it stabilizes the DNA double-helix upon binding, preventing force-induced DNA denaturation [29]. Because of the enormous consumption of caffeine, we have focused on its physiological effects, so it can be helpful in the possible prevention of DN by exhibiting its interaction with sorbitol [26].…”

Section: Introductionmentioning

confidence: 99%

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Free serum sorbitol and its interaction with caffeine: A suggestive approach for plausible remediation of diabetic neuropathy

Srivastava

Sen

2020

Biotech and App Biochem

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The measure of sorbitol in serum can act as a good indicator in the monitoring of the diabetic complications. To analyze the sorbitol level in serum medium, fluorometric enzymatic assay was performed. To remove the excess sorbitol from the body, proposed binding of sorbitol with caffeine was investigated. Their interaction in serum medium was studied and established by UV-Vis, fluorescence spectrophotometry, and time-correlated single photon counting (TCSPC). The linear calibration of sorbitol (in the range 10-50 mM) was done using UV-Vis spectrophotometry. Time scan experiments furnished the reaction rate of sorbitol assayed solution as well as sorbitol-caffeine complex as 0.021 min −1 and 0.018 min −1 , respectively. A sudden drop was observed in the fluorescence lifetime of reduced nicotinamide adenine dinucleotide (NADH) present in sorbitol assayed solution upon complexation with caffeine, that is, from 1.774 × 10 −09 to 1.23 × 10 −10 Sec, which indicates the hindrance in the formation of NADH and the probable formation of some other species. Isothermal titration calorimetric experiments clearly indicate the number of binding sites (i.e., 3.89, 1.40, and 2.07) that exist between sorbitol and caffeine at the complexation ratio of 1:1.2, 1:1.5, and 1:3. The present method can be helpful in pharmacological and therapeutic studies of sorbitol using caffeine for treating diabetic neuropathy.

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Effects of caffeine on the structure and conformation of DNA: A force spectroscopy study

Cited by 12 publications

References 42 publications

Hydroxychloroquine Exhibits a Strong Complex Interaction with DNA: Unraveling the Mechanism of Action

Hydroxychloroquine Exhibits a Strong Complex Interaction with DNA: Unraveling the Mechanism of Action

Dietary Modulation of Bacteriophages as an Additional Player in Inflammation and Cancer

Free serum sorbitol and its interaction with caffeine: A suggestive approach for plausible remediation of diabetic neuropathy

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