Effects of Caffeic Acid Phenethyl Ester on Pancreatitis in Rats

Türkyılmaz, Serdar; Alhan, Etem; Erçín, Cengiz; Vanizor, Birgül; Kaklıkkaya, Neşe; Ateş, Burhan; Erdoğan, Selım; Topaloğlu, Serdar

doi:10.1016/j.jss.2007.04.019

Cited by 20 publications

(18 citation statements)

References 43 publications

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“…At present, all attention is focused on antioxidant and anti-inflammatory therapies. 2,3,4,6,18,20 Quercetin has been reported to exert multiple biological effects such as antioxidant, anti--inflammatory, and antihistaminic effects etc.…”

Section: ■ Discussionmentioning

confidence: 99%

“…1,2,4,8,15 The role of oxidative stress in the pathogenesis of AP and the benefits of antioxidants have been the subject of numerous studies. 14,[16][17][18][19] Recent studies have focused on antioxidant and anti-inflammatory properties of phenolic compounds. 2,4,6,20 Quercetin (3,5,7,3',4' pentahydroxyflavone) is a plant-derived phenolic compound belonging to a class of substances known as flavonoids.…”

Section: Methodsmentioning

confidence: 99%

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The effect of quercetin on cerulein-induced acute pancreatitis

Kahraman¹,

Vurmaz²,

Koca³

et al. 2017

Medical Express

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OBJECTIVE:The aim of this study was to evaluate the protective and therapeutic effects of quercetin on pancreatic injury in cerulein-induced acute pancreatitis. METHOD: Thirty-two rats were randomly divided into four groups, eight per group: (CT): untreated controls, (CER) treated with cerulein, 50 μg/kg body weight; (Q+CER) pre-treatment with quercetin, 100 mg/kg body weight, followed by cerulein, 50 μg/kg; (CER+Q) post-treatment, cerulein followed by quercetin, same doses. Cerulein was divided into four doses, given at 1-hour intervals by intraperitoneal injection. Quercetin was given either 1-hour before (in pre-treatment group) or 1-hour after (in post-treatment group) cerulein. Pancreatic malondialdehyde (MDA), carbonyl, myeloperoxidase (MPO), tumor necrosis factor-alpha (TNF-a), interleukin-6 (IL-6), reduced and oxidized glutathione (GSH and GSSG, respectively) were measured. Histology of the pancreas was studied. RESULTS: (1) MDA, carbonyl, MPO, TNF-a and IL-6 levels were significantly higher in CER vs CT rats. (2) MDA, carbonyl, MPO and TNF-α decreased significantly in pre-treated rats vs. CER. (3) MDA, MPO, TNF-α, IL-6 were significantly lower in post-treated rats vs. CER. (4) The reduced vs. oxidized glutathione ratio (GSH/GSSG) of was significantly lower CER vs. CT rats. (5) Pre-and post-treatment with quercetin significantly increased this ratio. (6) Pancreatic histology showed that quercetin had no significant effect on the histological image of the pancreas CONCLUSION: These results suggest that quercetin can attenuate the severity of cerulein-induced acute pancreatitis by acting as an antioxidant and anti-inflammatory agent and combating oxidative stress. Further studies are needed to clearly explain its utility on acute pancreatitis.

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Section: ■ Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

The effect of quercetin on cerulein-induced acute pancreatitis

Kahraman¹,

Vurmaz²,

Koca³

et al. 2017

Medical Express

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“…Administration of CAPE has been shown to completely block the production of ROS from activated neutrophils. Beyond that, CAPE can inhibit neutrophil infiltration during inflammatory process and protect tissues from oxidative stress due to reactive oxygen species and reduce the lipid peroxidation [6,7,8,9,10]. In other words, this effect is exerted by regulation of inflammation, immunomodulation and oxidation.…”

Section: Discussionmentioning

confidence: 99%

“…It has been widely used as an antioxidant against various oxidative processes in animal models [7,8,9,10,11,12,13,14]. …”

Section: Introductionmentioning

confidence: 99%

Effect of Caffeic Acid Phenethyl Ester on Intra-Abdominal Adhesion in Rats

Turgut

Sak

Türkçü³

et al. 2013

Gynecol Obstet Invest

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Background: To determine the impact of caffeic acid phenethyl ester (CAPE) on abdominal adhesion formation after laparotomy. Methods: Forty female rats were allocated into four distinct groups on which laparotomy alone; laparotomy with traumatization of the uterine horns; laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with saline, and laparotomy, traumatization of the uterine horns and intraperitoneal irrigation with CAPE were performed. After sacrifying the animals on the 14th postoperative day, histopathological examination and biochemical analysis were conducted to evaluate the formation of abdominal adhesions and antioxidant status. Results: In the CAPE group, total adhesion scores were significantly lower than in the control and saline groups. The CAPE group displayed less inflammation, giant cell formation, fibrosis and fibroblastic activity than the control group. On the other hand, the control group displayed higher total adhesion scores. Conclusion: The results of this study indicate that the administration of CAPE may have beneficial effects for the prevention of abdominal adhesion formation after laparotomy. Further clinical studies are mandatory to explore the actual therapeutic potential of CAPE.

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“…CAPE has several positive biological and pharmacological properties, such as antioxidant, antiinflammatory, anticarcinogenic, antiviral, antifungal, and immunomodulatory activities, and has been shown to inhibit the growth of different types of transformed cells and to inhibit pulmonary fibrosis [10]. At a concentration of 10 μM, it completely blocks the production of free oxygen radicals in human neutrophils and in the xanthine/ xanthine oxidase system [11,12] In addition, CAPE has not shown detrimental effects on normal cells.…”

Section: Introductionmentioning

confidence: 99%

Effects of Caffeic Acid Phenethyl Ester (CAPE) on Sepsis in Rats

et al. 2008

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Sepsis is still a major cause of the high mortality rate in the intensive care unit. Many studies have been published about the severity of sepsis, but the cause of mortality in sepsis and multiorgan failure is still obscure. This study investigated the effects of caffeic acid phenethyl ester (CAPE) particularly on the inflammatory and related histopathological changes in the lung, liver and kidney in an experimental sepsis model. Forty Sprague Dawley rats were used in this study, and were divided into four groups of ten rats each, as follows: Group I was given intraperitoneal saline infusion treatment. Group II was given intraperitoneal CAPE infusion treatment. Sepsis was induced in the animals in Group III (sepsis with saline infusion), while Group IV rats underwent induced sepsis plus CAPE infusion treatment (sepsis with CAPE infusion). Sampling was performed 48 h after treatment. The induction of sepsis resulted in a significant increase in serum glucose, leukocytes, urea, creatinine, LDH levels in BAL, plasma MDA, AST and ALT levels in the sepsis + saline group. The use of CAPE significantly decreased these parameters. Histopathological examination revealed less congestion, portal inflammation, and focal necrosis of the liver, and less congestion, edema, and emphysematous and inflammatory changes in the lung in the sepsis + CAPE group than in the other groups. These results support that CAPE may be used for the treatment of organ failure during sepsis.

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Effects of Caffeic Acid Phenethyl Ester on Pancreatitis in Rats

Cited by 20 publications

References 43 publications

The effect of quercetin on cerulein-induced acute pancreatitis

The effect of quercetin on cerulein-induced acute pancreatitis

Effect of Caffeic Acid Phenethyl Ester on Intra-Abdominal Adhesion in Rats

Effects of Caffeic Acid Phenethyl Ester (CAPE) on Sepsis in Rats

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