Effects of Burdock tea on recurrence of colonic diverticulitis and diverticular bleeding: An open-labelled randomized clinical trial

Abstract

Colonic diverticular bleeding (CDB) and acute colonic diverticulitis (ACD) show high recurrence rates. The establishment of optimal strategies that prevent the recurrence of CDB and ACD is a major concern among gastroenterologists. This study aimed to assess the efficacy of burdock tea for preventing CDB and ACD recurrences. Newly diagnosed patients with CDB (n = 91) or ACD (n = 70) were randomly assigned into two groups. The experimental group received 1.5 g of burdock tea three times a day, whereas the control group did not receive any treatment. The median (interquartile range) of observation for recurrence of CDB or ACD was 22.0 (14.1) months and 30.3 (18.6), respectively. The burdock tea treatment showed significant preventive effects on recurrence of ACD. A lower ACD recurrence rate (5/47 [10.6%] vs. 14/44 [31.8%]) and longer recurrence-free duration was observed in the burdock tea group (59.3 months [95% CI: 54.0–64.7] vs. 45.1 months [95% CI: 37.1–53.0] by the Kaplan-Meier analysis; p = 0.012 by log rank test) than in the control group, although there was no significant preventive effects on the CDB recurrence. This randomized clinical trial demonstrated that daily intake of burdock tea could be an effective strategy for prevention of ACD recurrence, but not for CDB recurrence.

Fragility of Statistically Significant Outcomes in Colonic Diverticular Disease Randomized Trials: A Systematic Review

“…From 1271 citations, 15 RCTs with a total of 1434 patients were included (Table 1). 15–29 A Preferred Reporting Items for Systematic Reviews and Meta-Analyses flow diagram of the study selection process is illustrated in Figure 1. Table 1 presents details of the included RCTs.…”

“…From 1271 citations, 15 RCTs with a total of 1434 patients were included (Table 1). [15][16][17][18][19][20][21][22][23][24][25][26][27][28][29] with complicated diverticular disease (53.3%), 6 evaluated patients with uncomplicated disease (40.0%), and 1 evaluated patients with diverticular bleeding (6.7%). Three RCTs were industry funded (23.1%).…”

Arctiin-reinforced antioxidant microcarrier antagonizes osteoarthritis progression

“…In regards to degenerative musculoskeletal disorders, e.g., OA, osteoporosis (OP) [ 24 ], and intervertebral disc degeneration (IVDD) [ 25 ], the beneficial effects of classical Chinese herbal formulae have been fully established. Clinically, a randomized controlled trial (RCT) found that oral administration of Burdock root tea (1.5 g) three times per day decreased the recurrence rate of acute colonic diverticulitis (ACD) by 20% as compared to the control group [ 26 ]. Additionally, daily consumption of Burdock root tea (6 g) decreased serum inflammatory cytokines such as interleukin-6 (IL-6), C-reactive protein (CRP), and malondialdehyde, while increasing SOD activity to alleviate oxidative stress in patients with KOA [ 27 ].…”