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Loss of extracellular matrix (ECM) of cartilage due to oxidative stress injury is one of the main characteristics of osteoarthritis (OA). As a bioactive molecule derived from the traditional Chinese Burdock, arctiin exerts robust antioxidant properties to modulate redox balance. However, the potential therapeutic effects of arctiin on OA and the underlying mechanisms involved are still unknown. Based on the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP) tool, Burdock-extracted small molecule arctiin was identified as a potential anti-arthritic component. In vitro, treatment using arctiin rescued the interleukin (IL)-1β-induced activation of proteinases and promoted the cartilage ECM synthesis in human chondrocytes. In vivo, intraperitoneal injection of arctiin ameliorated cartilage erosion and encountered subchondral bone sclerosis in the post-traumatic OA mice. Transcriptome sequencing uncovered that arctiin-enhanced cartilage matrix deposition was associated with restricted oxidative stress. Mechanistically, inhibition of nuclear factor erythroid 2-related factor 2 (NRF2) abolished arctiin-mediated anti-oxidative and anti-arthritic functions. To further broaden the application prospects, a gellan gum (GG)-based bioactive gel (GG-CD@ARC) encapsulated with arctiin was made to achieve long-term and sustained drug release. Intra-articular injection of GG-CD@ARC counteracted cartilage degeneration in the severe (12 weeks) OA mice model. These findings indicate that arctiin may be a promising anti-arthritic agent. Furthermore, GG-modified bioactive glue loaded with arctiin provides a unique strategy for treating moderate to severe OA. Graphical Abstract

ObjectiveTo investigate the effect of bilateral bone cement distribution on the clinical efficacy of percutaneous kyphoplasty (PKP) in the treatment of osteoporotic vertebral compression fracture (OVCF).MethodsAccording to strict inclusion and exclusion criteria, 109 cases of OVCF patients treated with bipedicular PKP were included in this study from August 2018 to July 2020. According to the distribution morphology of bilateral bone cement in vertebral body, patients were divided into 3 groups, including Group A (n = 44): bilateral diffuse type; Group B (n = 31): bilateral dense type; Group C (n = 34): mixed type. To assess the clinical and radiographic efficacy of the surgery, the visual analogue scale (VAS) score, Oswestry disability index (ODI) score, anterior vertebral height (AVH), anterior vertebral height ratio (AVHR) and local kyphotic angle (LKA) were recorded at preoperatively, 2 days after surgery and 1 year after surgery.ResultsCompared with the preoperative recorded value, the VAS score, ODI score, AVH, AVHR and LKA of the three groups were significantly improved at 2 days after surgery and 1 year after surgery (p < 0.05). At 1 year after surgery, the VAS score of Group A was better than that of groups B and C (p < 0.05), and there were significantly differences in ODI score, AVH, and LKA between Group A and Group B (p < 0.05). Compared with other bone cement distribution patterns, the incidence of recompression in bilateral diffuse bone cement distribution pattern was lower (p < 0.05).ConclusionIn the mid-term follow-up of patients undergoing bipedicular PKP, diffuse and symmetrical distribution of bone cement can obtain better clinical improvement and lower the incidence of secondary compression.

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Objective： To explore the clinical effect of bone cement combined with balloon expansion in the treatment of osteoporotic vertebral oblique compression fracture.Methods： This study retrospectively reviewed the patients who were diagnosed with osteoporotic vertebral oblique compression fracture between January 2017 and July 2019. According to the method of surgery, 41 patients received bone cement treatment alone (group A) and 44 patients received bone cement combined with balloon expansion (group B). The visual analogue scale (VAS), oswestry disability index (ODI), scoliosis angle (SA), height of long side (HL), height of short side (HS) and lateral height difference (LHD) before operation and 3 days and 1 year after operation were compared between the two groups. The operation time, fluoroscopic time, hospital stay, cement volume and complications were also compared between the two groups.Results：The VAS and ODI differed significantly between the groups 1 year after operation(P＜0.05). Compared with the preoperative results, there were significant differences in SA, HL, HS and LHD 3 days and 1 year after surgery(P＜0.05). There were significant differences in SA, HS and LHD 3 days and 1 year after surgery between the two groups(P＜0.05). A total of 21 patients in group A and 6 patients in group B experienced scoliosis after operation, there were also significant differences between groups(P＜0.05).Conclusions：Bone cement combined with balloon expansion and bone cement alone are all effective in the treatment of osteoporotic vertebral oblique compression fracture, but bone cement combined with balloon expansion had better long-term clinical efficacy.

ObjectiveTo explore the clinical effect of bone cement combined with balloon expansion in the treatment of osteoporotic vertebral oblique compression fracture. MethodsThis study retrospectively reviewed the patients who were diagnosed with osteoporotic vertebral oblique compression fracture between January 2017 and July 2019. According to the method of surgery, 41 patients received bone cement treatment alone (group A) and 44 patients received bone cement combined with balloon expansion (group B). The visual analogue scale (VAS), oswestry disability index (ODI), scoliosis angle (SA), height of long side (HL), height of short side (HS) and lateral height difference (LHD) before operation and 3 days and 1 year after operation were compared between the two groups. The operation time, fluoroscopic time, hospital stay, cement volume and complications were also compared between the two groups. ResultsThe VAS and ODI differed significantly between the groups 1 year after operation(P＜ 0.05). Compared with the preoperative results, there were significant differences in SA, HL, HS and LHD 3 days and 1 year after surgery(P＜0.05). There were significant differences in SA, HS and LHD 3 days and 1 year after surgery between the two groups(P＜0.05). A total of 21 patients in group A and 6 patients in group B experienced scoliosis after operation, there were also significant differences between groups(P＜0.05). ConclusionsBone cement combined with balloon expansion and bone cement alone are all effective in the treatment of osteoporotic vertebral oblique compression fracture, but bone cement combined with balloon expansion had better long-term clinical efficacy.