2019
DOI: 10.1111/jcmm.14548
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Abstract: As a cytoplasmic protein tyrosine kinase, Bruton's tyrosine kinase (Btk) is widely considered as a vital kinase in many aspects of different physiologic processes. It is engaged in many important signalling pathways related to the immune response, such as the B cell receptor pathway, pattern‐recognition receptor pathway, and triggering receptor expressed on myeloid cell pathway. Recent studies have increasingly focused on the important role of Btk in various inflammatory diseases, which are related to Btk expr… Show more

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Cited by 24 publications
(18 citation statements)
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References 65 publications
(110 reference statements)
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“…studies have confirmed the role of BTK in monocyte/macrophage and neutrophil activity(49,50), which contribute to the inflammatory response to infections. A study that examined lungs of COVID-19 patients confirmed that the infiltrate of immune cells in alveoli were majorly macrophages and monocytes, while moderate multinucleated giant cells, minimal lymphocytes, eosinophils and neutrophils were also observed(51).…”
mentioning
confidence: 77%
“…studies have confirmed the role of BTK in monocyte/macrophage and neutrophil activity(49,50), which contribute to the inflammatory response to infections. A study that examined lungs of COVID-19 patients confirmed that the infiltrate of immune cells in alveoli were majorly macrophages and monocytes, while moderate multinucleated giant cells, minimal lymphocytes, eosinophils and neutrophils were also observed(51).…”
mentioning
confidence: 77%
“…This finding supports the suggested anti-inflammatory effect of BTK inhibitors in the lung. Similar studies have also revealed the role of BTK in neutrophil and macrophage/monocyte activity [ 60 , 61 ], which contribute to the inflammatory response to infections.…”
Section: The Role Of Btk Inhibitors In the Treatment Of Covid-19mentioning
confidence: 68%
“…In general, BTK signaling regulates downstream B cell receptor, Fc receptor and TLR7/8/3 signaling pathways. The inhibition of BTK could elevate the type I interferon levels and activate TLR signaling in systemic lupus erythematosus and different experimental models [34][35][36][37]. Another study reported that blocking the BTK, TLR3-induced protein kinase B (Akt), mitogen-activated protein kinase (MAPK) and nuclear factor (NF)-κB signaling pathways enhanced the antiviral responses in mice models [38].…”
Section: Discussionmentioning
confidence: 99%