Effects of brain natriuretic peptide on forearm vasculature: comparison with atrial natriuretic peptide

Zander, Kim van der; Houben, A. J. H. M.; Kroon, Abraham A.; Leeuw, Peter W. de

doi:10.1016/s0008-6363(99)00234-5

Cited by 37 publications

(24 citation statements)

References 31 publications

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“…5 Additionally, in studies of healthy volunteers, infusion of natriuretic peptides increases FMD. 6 We submit that the contrasting directionality of associations observed in our study versus some other reports 1-3 may be due to differences in the study samples. We studied a large communitybased sample with a low prevalence of cardiovascular disease and diabetes, whereas the studies cited by the authors evaluated referral samples with a greater prevalence of risk factors and/or cardiovascular disease.…”

contrasting

confidence: 73%

Response to Letter Regarding Article, “Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function”

et al. 2006

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contrasting

confidence: 73%

Response to Letter Regarding Article, “Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function”

et al. 2006

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“…18 Our previous finding that BNP is a mild dilator compared with equimolar doses of ANP supports the concept of a balance between vasodilating and vasoconstrictor forces. 10 An additional argument may be that in in vitro experiments, we were unable to demonstrate consistently BNPinduced vasodilation in human and rat tissue. In phenylephrine-preconstricted human omental and pericardial resistance arteries, and rat mesenteric, renal, saphenal, and uterine arteries, in only 4 of 14 experiments 10 nmol/L BNP (human BNP-32 and rat BNP-45) caused a relaxation.…”

Section: Van Der Zander Et Al Effect Of Bnp In Human Kidney 121mentioning

confidence: 87%

“…With this approach, we and others have demonstrated previously that BNP induces a dose-dependent vasodilation in forearm vasculature. 10,11 In the present study, we investigated whether BNP has any direct effects on the renal circulation. To this end, we infused BNP into the renal artery of hypertensive patients who were scheduled for renal angiography.…”

mentioning

confidence: 99%

Does Brain Natriuretic Peptide Have a Direct Renal Effect in Human Hypertensives?

Zander

Houben²,

Wierema³

et al. 2003

Hypertension

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Abstract-Systemic infusion of brain natriuretic peptide (BNP) stimulates natriuresis and diuresis but has variable effects on the renal vasculature. In this study, we investigated whether BNP has any direct effects on the kidney in hypertensive patients. Three stepwise increasing doses of BNP (60, 120, and 180 pmol/min) or placebo were infused into the renal artery of 26 hypertensive patients. Renal blood flow was determined with the 133 Xenon washout technique. Before and after infusion of BNP, arterial and venous blood samples were taken for cGMP, renin, and creatinine concentration. Intra-arterial blood pressure and heart rate were monitored continuously. Intrarenal BNP infusion did not induce significant changes in renal blood flow despite increases in circulating levels of cGMP. The latter, however, was not associated with changes in the cGMP gradient across the kidney. In addition, we did not find any BNP-related changes in the secretion of active renin and in creatinine extraction. At the highest dose, heart rate increased after BNP infusion without a change in mean intra-arterial blood pressure. In conclusion, this study suggests that at least in hypertensive subjects, BNP has no direct intrarenal hemodynamic effects and that the rise in circulating cGMP without changes in net renal extraction of this second messenger is related to a primary extrarenal target of BNP. Key Words: natriuretic peptides Ⅲ vasodilation Ⅲ hypertension, renal Ⅲ human Ⅲ kidney Ⅲ hemodynamics Ⅲ vasoconstriction Ⅲ hormones S ystemic infusion of brain natriuretic peptide (BNP) stimulates natriuresis and diuresis 1-6 and inhibits plasma renin activity [1][2][3]7,8 but has variable effects on the renal vasculature. Although most but not all studies in healthy humans reported that BNP infusion increases glomerular filtration rate, 1,5-7 renal plasma flow has been found to decrease, 1,7 to increase, 5 or to remain unchanged. 3,8 Variations in the renovascular effects of BNP could be related to differences in BNP levels reached during the experiments, but it is equally possible that the renal changes are, in part, secondary to systemic effects. Indeed, BNP not only acts on the kidney but also affects blood pressure, heart rate, cardiac output, and systemic vascular resistance. 2,3,5,6,8,9 In those studies in which changes in renal plasma flow are reported, it is important to keep in mind that such alterations may simply be due to concurrent changes in cardiac output. If, for instance, renal fraction (that is, the proportion of cardiac output perfusing the kidneys) remains unaltered during systemic BNP infusion, it is unlikely that the peptide has exerted a direct effect on the renal vasculature. If, on the other hand, renal fraction increases, relative renal vasodilation must have occurred. In most studies, this has not been taken into account.Local administration of BNP in a regional vascular bed in amounts that will not have systemic effects allows for assessing whether BNP has any direct effects on certain parts of the circulation. Wi...

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“…49 Accordingly, the potency for vasorelaxation is also markedly less. 58 Thus, it is possible that BNP (which is constitutively expressed in cardiomyocytes) mainly acts as a local paracrine antifibrotic factor within the heart (ie, because fibroblasts express relatively high levels of both GC-A and GC-B). However, the following observations suggest that BNP might activate another so-far-unknown receptor: (1) Whereas the amino acid sequences of ANP and CNP are conserved among animal species, the sequence of BNP is highly different between humans, rats, and mice.…”

Section: Vascular Effectsmentioning

confidence: 99%

Structure, Regulation, and Function of Mammalian Membrane Guanylyl Cyclase Receptors, With a Focus on Guanylyl Cyclase-A

Kühn

2003

Circulation Research

237

161

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Abstract-Besides soluble guanylyl cyclase (GC), the receptor for NO, there are at least seven plasma membrane enzymes that synthesize the second-messenger cGMP. All membrane GCs (GC-A through GC-G) share a basic topology, which consists of an extracellular ligand binding domain, a short transmembrane region, and an intracellular domain that contains the catalytic (GC) region. Although the presence of the extracellular domain suggests that all these enzymes function as receptors, specific ligands have been identified for only three of them (GC-A through GC-C). GC-A mediates the endocrine effects of atrial and B-type natriuretic peptides regulating arterial blood pressure and volume homeostasis and also local antihypertrophic actions in the heart. GC-B is a specific receptor for C-type natriuretic peptide, having more of a paracrine function in vascular regeneration and endochondral ossification. GC-C mediates the effects of guanylin and uroguanylin on intestinal electrolyte and water transport and on epithelial cell growth and differentiation. GC-E and GC-F are colocalized within the same photoreceptor cells of the retina and have an important role in phototransduction. Finally, the functions of GC-D (located in the olfactory neuroepithelium) and GC-G (expressed in highest amounts in lung, intestine, and skeletal muscle) are completely unknown. This review discusses the structure and functions of membrane GCs, with special emphasis on the physiological endocrine and cardiac functions of GC-A, the regulation of hormone-dependent GC-A activity, and the relevance of alterations of the atrial natriuretic peptide/GC-A system to cardiovascular diseases. (Circ Res. 2003;93:700-709.)

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Effects of brain natriuretic peptide on forearm vasculature: comparison with atrial natriuretic peptide

Cited by 37 publications

References 31 publications

Response to Letter Regarding Article, “Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function”

Response to Letter Regarding Article, “Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function”

Does Brain Natriuretic Peptide Have a Direct Renal Effect in Human Hypertensives?

Structure, Regulation, and Function of Mammalian Membrane Guanylyl Cyclase Receptors, With a Focus on Guanylyl Cyclase-A

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