Response to Letter Regarding Article, “Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function”

Acute aortic syndrome (AAS) describes several life-threatening aortic pathologies. These include intramural hematoma, penetrating aortic ulcer, and acute aortic dissection (AAD). Advances in both imaging and endovascular treatment have led to an increase in diagnosis and improved management of these often catastrophic pathologies. Patients, who were previously consigned to medical management or high-risk open surgical repair, can now be offered minimally invasive solutions with reduced morbidity and mortality. Information from the International Registry of Acute Aortic Dissection (IRAD) database demonstrates how in selected patients with complicated AAD the 30-day mortality from open surgery is 17% and endovascular stenting is 6%. Despite these improvements in perioperative deaths, the risks of stroke and paraplegia remain with endovascular treatment (combined outcome risk 4%). The pathophysiology of each aspect of AAS is described. The best imaging techniques and the evolving role of endovascular techniques in the definitive management of AAS are discussed incorporating strategies to reduce perioperative morbidity.

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Management of Acute Aortic Syndrome and Chronic Aortic Dissection

Nordon

Hinchliffe

Loftus

et al. 2010

Cardiovasc Intervent Radiol

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Early entry closure for acute type B aortic dissection by open stent grafting

Uchida

Katayama

Tamura

et al. 2011

Gen Thorac Cardiovasc Surg

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Determinants of Long-Term Mortality in Patients With Type B Acute Aortic Dissection

Sakakura

Kubo

Ako

et al. 2009

American Journal of Hypertension

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Response to Letter Regarding Article, “Cross-Sectional Relations of Multiple Biomarkers From Distinct Biological Pathways to Brachial Artery Endothelial Function”

Cited by 10 publications

References 6 publications

Management of Acute Aortic Syndrome and Chronic Aortic Dissection

Management of Acute Aortic Syndrome and Chronic Aortic Dissection

Early entry closure for acute type B aortic dissection by open stent grafting

Determinants of Long-Term Mortality in Patients With Type B Acute Aortic Dissection

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