Effects of Boron on Structure and Antioxidative Activities of Spleen in Rats

Abstract

In order to determine the relationship between boron and development of the spleen, especially in the promoting biological effects, we examined the effects of different levels of boron on weight, organ index, microstructure, and antioxidative activities of the spleen in rats. Sprague-Dawley (SD) rats were selected and treated with different concentrations of boron, and then, the organs were resected and weighed. One half of the tissue was fixed and embedded in paraffin to observe tissue structure changes. The other half of the tissue was homogenated for determining the antioxidant activities. The results showed that 40 mg/L of boron could increase weight, organ indexes, and antioxidant capacity of spleens and improve the spleen tissue structure, while the boron concentration above 80 mg/L could decrease weight, organ indexes, and antioxidant capacity of spleens and damage the spleen tissue structure. The higher the concentration, the more serious the damage was. Especially at the concentration of 640 mg/L, it could significantly inhibit the development of the spleen and even exhibit toxic effect. Hence, low boron concentration played a protective role in the development of the spleen, while high boron concentration could damage the organs and even produce toxic effect.

Dose-dependent Effect of Boric Acid on Myogenic Differentiation of Human Adipose-derived Stem Cells (hADSCs)

“…While dietary low-dose boron intake has improved organ indexes and tissue structure in rats, elevated levels of boron treatment (640 mg boric acid/L) has resulted in low organ weight and abnormal tissue structure [31]. Similarly, the results of the current study revealed that both low-and high-dose boron treatments increased myogenic lineage-specific gene expression in early stage of differentiation; high-dose boron treatment significantly decreased the myogenic differentiation potential of hADSCs.…”

Selected physiological effects of boron compounds for animals and humans. A review

“…Boron reduces DNA damage and lipid peroxidation. Türkez et al, 2007;Hu et al, 2014;Ince et al, 2014;Celikezen et al, 2015;Boyacioglu et al, 2017;Abdelnour et al, 2018;Uluisik et al, 2018;Hunter et al, 2019 Anti-inflammatory properties of boron…”

Yumurtaya Enjekte Edilen Farklı Dozlarda Borik Asitin Bursa Fabrisius ve Dalak Üzerine Etkileri: Histolojik ve Stereolojik Çalışma

“…In a study carried out with rats boron increased weight and relative weight of the spleen [10] . The difference was considered to be associated with the difference in species.…”

“…It was shown that boron did not exhibit toxic effects on the reproduction system of rats and was found to be effective on skeletal system at high doses [9] . In another study, boron was found to decrease spleen weight and besides, it caused arthritis in rats [10] . Bai and Hunt [11] , reported that boron increased the level of antibodies.…”