Effects of Blending a Nonionic and an Anionic Cellulose Ether Polymer on Drug Release from Hydrophilic Matrix Capsules

Hussain, Ajaz; Johnson, Robert D.; Shivanand, Padmaja; Zoglio, M.A.

doi:10.3109/03639049409042668

Cited by 17 publications

(8 citation statements)

References 14 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…propranolol H + (CMC − ), which retards the release. Similar results were previously reported for NaCMC and HPMC combinations with propranolol hydrochloride as a model API (23,47,48). The authors claimed an ionic interaction by hydrogen bonding between the amine group of propranolol HCl and carboxyl group of NaCMC resulted in a formation of a propranolol-NaCMC complex leading to a retardation of the drug release rate from HPMC ER matrices.…”

Section: Effect Of Nacmc On Drug Release From Peo Er Matricessupporting

confidence: 83%

“…The rapid drug dissolution/diffusion and relatively fast erosion (n>0.8, Table IV) of those matrices may be explained by the high aqueous solubility and hygroscopic nature of NaCMC due to the presence of ionized carboxylic acid groups within the polymer structure. The latter may possibly lead to an increase in rate and extent of water uptake due to ion-pair repulsion, stretch in the gel network and break of the bonds responsible for the gel structure (46)(47)(48). The slowest theophylline release was obtained from PEO tablets.…”

Section: Effect Of Nacmc On Drug Release From Peo Er Matricesmentioning

confidence: 99%

See 1 more Smart Citation

The Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide Extended Release Matrices

Palmer¹,

Levina²,

Nokhodchi

et al. 2011

AAPS PharmSciTech

View full text Add to dashboard Cite

Anionic polymer sodium carboxymethylcellulose (CELLOGEN® HP-HS and/or HP-12HS) was investigated for its ability to influence the release of three model drugs propranolol hydrochloride, theophylline and ibuprofen from polyethylene oxide (POLYOX™ WSR 1105 and/or Coagulant) hydrophilic matrices. For anionic ibuprofen and non-ionic theophylline, no unusual/unexpected release profiles were obtained from tablets containing a mixture of two polymers. However, for cationic propranolol HCl, a combination of polyethylene oxide (PEO) with sodium carboxymethylcellulose (NaCMC) produced a significantly slower drug release compared to the matrices with single polymers. The potential use of this synergistic interaction can be a design of new extended release pharmaceutical dosage forms with a more prolonged release (beyond 12 h) using lower polymer amount, which could be particularly beneficial for freely water-soluble drugs, preferably for once daily oral administration. In order to explain changes in the obtained drug release profiles, Fourier transform infrared absorption spectroscopy was performed. A possible explanation for the more prolonged propranolol HCl release from matrices based on both PEO and NaCMC may be due to a chemical bond (i.e. ionic/electrostatic intermolecular interaction) between amine group of the cationic drug and carboxyl group of the anionic polymer, leading to a formation of a new type/form of the active (i.e. salt) with sustained release pattern.

show abstract

Section: Effect Of Nacmc On Drug Release From Peo Er Matricessupporting

confidence: 83%

Section: Effect Of Nacmc On Drug Release From Peo Er Matricesmentioning

confidence: 99%

The Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide Extended Release Matrices

Palmer¹,

Levina²,

Nokhodchi

et al. 2011

AAPS PharmSciTech

View full text Add to dashboard Cite

show abstract

“…Polymeric hydrogels are studied for controlled release applications because of their ability in producing drug release close to zero-order kinetics (7)(8)(9)(10)(11)(12)(13). Gums from natural sources hydrate and swell on contact with water and have been used for the preparation of single unit dosage forms (14).…”

Section: Introductionmentioning

confidence: 99%

Release Behaviour of Propranolol HCl from Hydrophilic Matrix Tablets Containing Psyllium Powder in Combination with Hydrophilic Polymers

et al. 2011

View full text Add to dashboard Cite

Abstract. The objective of this study was to investigate the release behaviour of propranolol hydrochloride from psyllium matrices in the presence hydrophilic polymers. The dissolution test was carried out at pH 1.2 and pH 6.8. Binary mixtures of psyllium and hydroxypropyl methylcellulose (HPMC) used showed that an increase in the percentage of HPMC in the binary mixtures caused a significant decrease in the release rate of propranolol. Psyllium-alginate matrices produced lower drug release as compared to when the alginate was the matrix former alone. When sodium carboxy methyl cellulose (NaCMC) was incorporated into the psyllium, the results showed that matrices containing the ratio of psyllium-NaCMC in the 1:1 ratio are able to slow down the drug release significantly as compared to matrices made from only psyllium or NaCMC as retardant agent suggesting that there could be a synergistic effect between psyllium and NaCMC. The double-layered tablets showed that the psyllium and HPMC in the outer shell of an inner formulation of psyllium alone had the greatest effect of protecting the inner core and thus producing the lowest drug release (DE=38%, MDT=93 min). A significant decrease in the value of n in Q=kt n from 0.70 to 0.51 as the psyllium content was increased from 50 to 150 mg suggests that the presence of psyllium in HPMC matrices affected the release mechanism. Psyllium powder had the ability in the combination with other hydrophilic polymers to produce controlled release profiles. Care and consideration should as such be taken when formulating hydrophilic matrices in different combinations.

show abstract

“…Hydrophilic capsule matrices have previously been considered as a means of obtaining hydrodynamically balanced systems for prolonging gastric residence time (13). The use of hydrophilic matrix capsules as an alternative to hydrophilic matrix tablets has been considered less frequently (14)(15)(16). An objective of the present study was to investigate the relationship between porosity and drug release in both tablet and capsule matrix systems.…”

Section: Introductionmentioning

confidence: 99%

Tablet and Capsule Hydrophilic Matrices Based on Heterodisperse Polysaccharides Having Porosity-Independent In Vitro Release Profiles

Kelly¹,

Tobyn

Staniforth

2000

Pharmaceutical Development and Technology

View full text Add to dashboard Cite

The purpose of the study was to investigate the release-controlling action of a swellable hydrophilic material based on heterodisperse polysaccharides (HP) in relation to the initial pore structure of the formulations. HP-based granules were produced under carefully controlled conditions and compacted into matrix tablets having equivalent tablet thickness. Quantification of pore structure using mercury porosimetry showed that the tablets had substantially different pore volumes and pore size distributions. Dissolution studies demonstrated that release of a water-soluble model compound, benzamide, from swollen matrices was affected neither by total porosity nor median pore diameter of the initial dry matrix. To extend the concept of porosity-independent release further, HP-based formulations containing either diclofenac sodium or propranolol HCl were contained within hard gelatin capsules in the form of uncompacted granules. This produced a dosage form with a high intraparticulate porosity in the dry state. Equivalent weights of the same formulations were also compacted into tablets. The in vitro release profiles from matrix tablets compacted from any of the formulations did not differ significantly from release profiles obtained when the same materials were contained uncompacted in hard gelatin capsules.

show abstract

Effects of Blending a Nonionic and an Anionic Cellulose Ether Polymer on Drug Release from Hydrophilic Matrix Capsules

Cited by 17 publications

References 14 publications

The Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide Extended Release Matrices

The Influence of Sodium Carboxymethylcellulose on Drug Release from Polyethylene Oxide Extended Release Matrices

Release Behaviour of Propranolol HCl from Hydrophilic Matrix Tablets Containing Psyllium Powder in Combination with Hydrophilic Polymers

Tablet and Capsule Hydrophilic Matrices Based on Heterodisperse Polysaccharides Having Porosity-Independent In Vitro Release Profiles

Contact Info

Product

Resources

About