Effects of bisoprolol on local vascular resistance

Abstract

Changes in systolic and diastolic blood pressure, heart rate, arterial blood flow and vascular resistance in the arm and in the leg were investigated in 9 healthy volunteers (22-40 years) after oral dosing with bisoprolol 10 mg, propranolol 40 mg, and placebo in a randomized double-blind cross-over study. Arterial blood flow and vascular resistance were determined in brachial and femoral arteries with unimpeded circulation, after exclusion of the hand or foot by placing a tourniquet on the wrist or ankle, and during post-ischaemic hyperaemia. Distal arterial occlusion allows one to isolate a predominantly muscular circulation in the forearm or, to a lesser extent, in the leg. Both active drugs induced a significant fall in heart rate and systolic blood pressure versus placebo with no significant difference between the drugs. Brachial and femoral flow rates were reduced by both drugs probably due to a fall in cardiac output, but the two beta blockers produced different effects on vascular resistance: propranolol significantly increased brachial vascular resistance compared with placebo and bisoprolol, both during unimpeded circulation and during occlusion of the hand by a wrist tourniquet. Bisoprolol had no influence on brachial vascular resistance. Both drugs induced small increases in femoral vascular resistance. The different action on local vascular resistance in the brachial artery territory could be interpreted as the expression of the high beta 1 selectivity of bisoprolol leaving the vascular beta 2 receptors unopposed, whereas non-selective propranolol acts on both beta-adrenoceptor subtypes.

Effects of AT1 receptor and beta1 receptor blocking on blood pressure, peripheral hemodynamic and lipid profile in statin‐treated hypertensive hypercholesterolemic patients

“…The positive effect of telmisartan on endothelial function is known from previous studies [18,19] This is in agreement with our observation, however, we did not observe an improvement in endothelial function in bisoprolol treated patients, where other Authors did [20,21]. This apparent discrepancy is maybe do to the fact that we have studied statin‐treated patients, where simvastatin is per se able to improve vascular resistance in hypercholesterolemic hypertensive patients [22].…”

Effects of Telmisartan and Bisoprolol on Blood Pressure, Peripheral Haemodynamic and Lipid Profile in Statin-Treated Hypertensive Hypercholesterolaemic Patients

“…[1,16] This is in agreement with our observation; however, we did not observe an improvement in endothelial function in bisoprolol-treated patients, where other studies did. [17,18] This apparent discrepancy is possibly due to the fact that we have studied statin-treated patients, where simvastatin is able to improve vascular resistance per se in hypercholesterolaemic hypertensive patients. [19] The endothelial dysfunction-improving effect could mitigate the one caused by bisoprolol, while it appears to be overcome by that of the RAS blockade.…”

Adverse Reactions with ??-Adrenoceptor Blocking Drugs An Update

“…iJ-Blockers with enhanced iJ(-selectivity might therefore be expected to have lesser effects upon vascular tone. Bailliart et al (1987) studied arterial blood flow and vascular resistance in the arm and leg in 9 healthy volunteers after bisoprolol 10mg, propranolol 40mg and placebo. Both iJ-blockers reduced brachial and femoral blood flow, possibly as a result of a fall in cardiac output.…”