Effects of AT1 receptor and beta1 receptor blocking on blood pressure, peripheral hemodynamic and lipid profile in statin‐treated hypertensive hypercholesterolemic patients

Abstract

Recent evidences suggest a relationship between angiotensin 1 (AT1) receptor gene expression and low density lipoprotein cholesterol (LDL-C) plasma level. We enrolled 16 untreated hypertensive hypercholesterolemic patients (57.4 +/- 7 years old) in a randomized, single-blind, cross-over design. All the patients were allocated to treatment with simvastatin 20 mg/day for 2 weeks, then randomly assigned to telmisartan (40-80 mg/day) or bisoprolol (5-10 mg/day). After 4 weeks the antihypertensive drugs have been withdrawn for a wash-out period of 2 weeks when they were treated with simvastatin alone, then they have been allocated to the alternative antihypertensive treatment for four additional weeks. We measured: systolic (SBP) and diastolic BP (DBP), 24-h mean BP (MBP), Baseline and post-ischemia forearm blood flow (FBF) and vascular resistance (FVR), and Lipid profile. After 2 weeks of treatment with Simvastatin, baseline and post-ischemic FBF increased (both P < 0.05), while baseline and post-ischemic FVR decreased (both P < 0.05). Standing DBP and MBP were reduced more after treatment with telmisartan than with bisoprolol (P < 0.05). Basal and post-ischemic FBF were significantly increased (P < 0.05 and P < 0.005, respectively) and basal and post-ischemic FVR significantly decreased (both P < 0.005) only after treatment with telmisartan, as well as plasma triglycerides (TG) (P < 0.05). From this preliminary study carried out on hypercholesterolemic hypertensive patients it appears that the association of telmisartan and simvastatin (but not of bisoprolol and simvastatin) could exert positive effects on a large quantity of vascular functionality parameters, just after a short treatment.

Telmisartan prevents angiotensin II‐induced endothelial dysfunction in rabbit aorta via activating HGF/Met system and PPARγ pathway

“…Telmisartan not only has a powerful and long‐lasting antihypertensive effect, but also can protect endothelial function, improve lipid metabolism, and inhibit atherosclerosis . However, it is still controversial about whether these benefits are independent of blood pressure lowering.…”

Vascular Effects of Antihypertensive Drug Therapy

“…Short-term treatment (4 weeks) of hypertensive, hypercholesterolemic patients with simvastatin and either telmisartan or bisoprolol improved forearm blood flow and reduced vascular resistance with the simvastatin-telmisartan combination but not with the bisoprolol combination [64]. We previously showed beneficial effects of peroxisome proliferator activated-receptor gamma (PPARγ) activators, thiazolidinediones or glitazones, on the vascular structure and function in experimental studies [65].…”