Effects of bis(α-furancarboxylato)oxovanadium(IV) on glucose metabolism in fat-fed/streptozotocin-diabetic rats

Effects of Dietary Onion (<i>Allium cepa</i> L.) in a High-Fat Diet Streptozotocin-Induced Diabetes Rodent Model

“…Several enzymes may be involved, but the best described in this regard are hepatic glucokinase and glucose-6-phosphatase [30,31] . Previous studies have reported that altered hepatic glucokinase and glucose-6-phosphatase activities result in the abnormal hepatic glycogen synthesis associated with the diabetic condition [32,33] . These studies also report that intervention with antidiabetic plant extracts or synthesized organic compounds further influence these enzymes, increasing liver glycogen synthesis and in turn lowering FBG levels [30,31] .…”

DNA binding and photocleavage properties of two mixed-ligand oxovanadium complexes

“…DNA-binding metal complexes, especially those with small molecular weight, have been extensively studied as DNA structural and conformational probes, DNA-dependent electron transfer and sequence-specific cleaving agents, and potential anticancer drugs [4][5][6]. As a trace bioelement existing in the human body, vanadium has been found to present a variety of biological activities such as antitumor, antimicrobial and insulin-enhancing effects, and its complexes have therefore been widely studied in order to promote these pharmacological effects and concomitantly reduce toxicity [7][8][9][10]. Because of their wide range of pharmacological applications, thiosemicarbazones were often chosen as such ligands for vanadium [11][12][13][14].…”

Bis(<I>α</I>-furancarboxylato)oxovanadium(IV) prevents and improves dexamethasone-induced insulin resistance in 3T3-L1 adipocytes

“…In the previous study, BFOV has been shown to counteract insulin resistance in fat-fed rats with STZ-induced diabetes (Niu et al 2007). To further understand the effect of BFOV on insulin-resistant glucose metabolism, we used dexamethasone-treated 3T3-L1 adipocytes as an in-vitro model of insulin resistance to evaluate the action of BFOV through the following pathways: (i) reversing the already existing insulin resistance, similar to the pathophysiology of type 2 diabetes mellitus; (ii) preventing the development of insulin resistance; (iii) enhancing the insulin action in 3T3-L1 adipocytes treated with dexamethasone.…”

“…Bis(-furancarboxylato)oxovanadium(IV) (BFOV; Figure 1) is a new organic vanadium complex which has been shown to be orally active and has hypoglycaemic effects in mice with type-1-like diabetes induced by alloxan and in rats with STZ-induced diabetes (Xie et al 2002(Xie et al , 2005Gao et al 2006). Further studies indicated that BFOV could control hyperglycaemia, decrease serum insulin level, increase insulin sensitivity index, improve glucose intolerance and inhibit gluconeogenesis in fat-fed rats with STZ-induced type-2-like diabetes (Niu et al 2007), showing that BFOV improved insulin resistance and type 2 diabetes. In-vitro, the compound markedly enhanced the uptake of 2-deoxy-D-[ 3 H]-glucose and inhibited lipolysis triggered by epinephrine (adrenaline) in isolated rat adipocytes Li et al 2008).…”